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Compound composition for lowering blood sugar and blood fat, preventing and/or treating diabetes and its complications and use thereof

A technology for diabetes and blood lipid lowering, which can be used in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, and can solve problems such as drug damage, usage restrictions, and limited therapeutic value.

Active Publication Date: 2021-06-15
巫臻玨 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs can effectively lower blood sugar, their use is strictly limited due to the damage of the drug to the body due to long-term use
At present, there are also pharmaceutical preparations for the treatment of diabetes. Although they can lower blood sugar to a certain extent, their therapeutic value is still limited.

Method used

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  • Compound composition for lowering blood sugar and blood fat, preventing and/or treating diabetes and its complications and use thereof
  • Compound composition for lowering blood sugar and blood fat, preventing and/or treating diabetes and its complications and use thereof
  • Compound composition for lowering blood sugar and blood fat, preventing and/or treating diabetes and its complications and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the influence of the ethanol extract of different composition on normal mouse blood sugar and triglyceride

[0031] 1. Tested medicinal materials: Houttuynia cordata, sourced from Jiangsu, identified as the dry aboveground part of the genus Phellodendron genus in the family Sanbaiaceae; Cortex Phellodendron, sourced in Sichuan, identified as the dry bark of the genus Phellodendron genus Rutaceae; peach blossom, sourced from Shandong, It is identified as the flower of the Rosaceae subgenus Peach.

[0032] 2. Composition:

[0033] Combination 1: Houttuynia cordata 75%, peach blossom 15%, cork 10%;

[0034] Combination 2: Houttuynia cordata 40%, peach blossom 30%, cork 30%;

[0035] Combination 3: Houttuynia cordata 20%, peach blossom 70%, cork 10%.

[0036] Combination 4: Houttuynia cordata 44%, peach blossom 38%, cork 18%.

[0037]3. Preparation of the test drug: 200g of each of the above combinations was taken according to the percentage by weight, and...

Embodiment 2

[0042] Embodiment two, the ethanol extract of different composition is to the influence of alloxan diabetic mouse blood sugar and triglyceride

[0043] Referring to the composition and extraction method of Example 1, the same amount of concentrated solutions of each combination was prepared and frozen for future use. An additional group of experiments was set up as a combination drug group (combination two + pills): combination two and 10 mg / kg pioglitazone were administered in combination.

[0044] Effect determination: Normal ICR mice, 22-26g, male, were fed adaptively for three days, then fed with a high-fat diet for one week, fasted for 12 hours, and intravenously injected with alloxan 55mg / kg (Sigma, alloxan, Lot&Filling code: 143780112609058) After 72 hours, an oral glucose tolerance test (glucose 2g / kg, ig) was carried out, and the mice with blood glucose ≥ 11mmol / L at 2 hours of glucose load were randomly divided into the following 6 groups (10 mice / group) as required....

Embodiment 3

[0048] Embodiment three, the water extract of different composition is to the influence of alloxan diabetic mouse blood sugar and triglyceride

[0049] With each composition and usage amount of embodiment two, water is used as solvent, material-to-liquid ratio is 1:15 for the first time, 1:10 for the second time, reflux extraction 2 times at 90 degrees, each time 1 hour, prepare each compound concentrated solution in the same amount Freeze for later use. Other

[0050] A group of experiments was added as a combination drug group (combination two + pills): combination two and 10 mg / kg pioglitazone were administered in combination.

[0051] Get ICR mice, with reference to the method of Example 2, prepare alloxan diabetic mice, the mice with glucose load (2g / kg, ig) 2h blood sugar ≥ 11mmol / L are randomly divided into the following 6 groups according to requirements (10 / group ). Each group is administered as required (with reference to Example 2, 0.1ml / 10g, ig), and the model c...

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Abstract

The invention relates to a compound composition for lowering blood sugar and blood fat, preventing and / or treating diabetes and its complications and its application. In terms of weight percentage, the raw material formula of the compound composition includes Houttuynia cordata 20%-75%, peach blossom 15‑70%, Cork 10%‑30%. The compound composition of the present invention has the advantages of good curative effect and few side effects for the prevention and treatment of diabetes, especially type 2 diabetes, hyperlipidemia, and diabetic complications, and can be used for the preparation of hypoglycemic and blood lipid-lowering, prevention and / or treatment of diabetes and its complications The medicine can also be used to prepare health care products for lowering blood sugar and blood fat, preventing diabetes and its complications.

Description

technical field [0001] The present invention relates to a compound composition used for lowering blood sugar and blood fat, preventing and / or treating diabetes and its complications and its preparation and health care application in products. Background technique [0002] Diabetes (diabetes) is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of islets and insulin resistance. , water and electrolytes and a series of metabolic disorder syndromes, clinically characterized by hyperglycemia. [0003] Diabetes is mainly divided into type 1 diabetes and type 2 diabetes. Among diabetic patients, type 2 diabetes accounts for about 95%, and type 2 diabetes is becoming more and more frequent and younger. As the blood sugar continues to rise, it causes systemic metabolic disorders, which can implicitly lead to chronic complications in multiple t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K45/06A61P3/10A61P3/06A23L33/105
CPCA61K36/736A61K36/756A61K36/78A61K45/06A61P3/06A61P3/10A61K2300/00
Inventor 巫臻玨王宝民
Owner 巫臻玨
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