Preparation method and novel applications of lobelia intiata extract
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A lobelia and extract technology, applied in the field of medicine, can solve the problems of lowering the quality of life, unsatisfactory treatment effect, difficulty in improving the quality of life and the like
Inactive Publication Date: 2017-08-11
NANJING SHENGDAOYUAN PHARMA CO LTD
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Problems solved by technology
These drugs have a certain therapeutic effect on PH, but in general, the drug treatment effect of PH is not satisfactory, and many PH patients still die from right heart failure; or they still have severe symptoms after receiving regular treatment, which is difficult to treat. Improves quality of life, and the side effect profile of these chemicals can lead to a further reduction in quality of life
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Examples
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Embodiment 1
[0019] Example 1 ： The preparation method of the lobelia extract for preventing and treating pulmonary hypertension:
[0020] Take 500g of lobelia medicinal material, add 70% ethanol and heat reflux for 3 times, reflux for 2 hours each time, and use 5L of solvent each time, combine the extracts, concentrate under reduced pressure, add water to stir and dilute, add to the treated 1kg HPD100 macroporous adsorption On the resin column, first wash with water until the collected solution is colorless, then elute with 70% ethanol until it is colorless or very light, combine the 70% ethanol eluents, concentrate and dry to obtain the extract.
Embodiment 2
[0021] Example 2 ： Effects of lobelia extract on pulmonary arterial hypertension induced by lobectomy combined with monocrotaline in SD rats
[0023] 2.2 Experimental drugs and equipment: lobelia extract, monocrotaline (purchased from Sigma), chloral hydrate, urethane, pressure transducer and PowerLab physiological information collection and processing system
[0024] 2.3 Severe PAH model was established by lobectomy combined with monocrotaline (MCT) injection: the rats were weighed, anesthetized by intraperitoneal injection of 12% urethane (8ml / kg), tracheal intubation was performed with a 16G arteriovenous catheter, and Harvard breathing was connected. Machine (tidal volume 2ml; frequency, 80 times / min; PEEP1.0cmH20. The left fourth intercostal space was inserted into the chest, the left lung lobe was ligated and removed, and the rat lung lobe was 1 lobe on the left, 4 lobes on the right, and th...
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Abstract
The invention relates to a preparation method and novel applications of lobelia intiata extract. According to the technical scheme provided by the invention, the lobelia intiata extract is used for treating pulmonary hypertension, and cardiovascular relevant diseases caused by pulmonary hypertension. The experimental study shows that the lobelia intiata extract provided by the invention can be used for preparing medicines for preventing or treating pulmonary hypertension, wherein the pulmonary hypertension comprises one or more symptoms of pulmonary arterial hypertension, pulmonary hypertension relevant to chronic hypoxic diseases, chronic thromboembolism pulmonary hypertension, and pulmonary hypertension caused by various unknown factors.
Description
technical field [0001] The invention relates to a preparation method and a new application of the lobelia extract, in particular to the application of the lobelia extract in preparing medicine for treating pulmonary hypertension, which belongs to the field of medicine. Background technique [0002] Pulmonary hypertension (PH) is a large group of malignant pulmonary vascular diseases characterized by increased pulmonary artery pressure, with or without small pulmonary artery disease, often leading to right heart failure and even death. PH has become a common disease that seriously threatens human physical and mental health. The diagnostic criteria are: mean pulmonary artery pressure (mPAP) ≥ 25 mmHg by right heart catheterization at sea level and at rest. [0003] PH can take the form of pulmonary arterial hypertension (PAH), in its idiopathic (IPAH) or hereditary (hPAH) form and also occurs in combination with other diseases (APAH) such as connective tissue diseases, portal...
Claims
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Application Information
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