Novel preparation method of beta-tricalcium phosphate/chitosan composite bionic hydrogel

A technology of tricalcium phosphate and hydrogel, which is used in tissue regeneration, medical science, prosthesis and other directions, can solve the problems of complex environment of bone tissue repair sites, and achieve the effects of safe synthesis, low cost and simple process

Inactive Publication Date: 2017-08-18
JIANGNAN UNIV
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Problems solved by technology

[0003] The purpose of the present invention is to overcome the application limitations of the existing bone repair materials when rapid bone filling is required, the environment of the bone tissue repair site is complex, or minimally invasive bone repair treatment is required, and to provide a simple preparation, low cost, Synthetic and safe novel composite biomimetic hydrogel preparation method

Method used

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Embodiment Construction

[0012] The present invention will be further described below in conjunction with specific examples.

[0013] A preparation method of a novel β-tricalcium phosphate / chitosan composite biomimetic hydrogel material adopts the following process steps:

[0014] 1. Prepare chitosan solution: dissolve chitosan in the dilute acetic acid solution of 1.0-1.5% (v / v) according to the ratio of 1.0-2.0% (w / v), mix well, place the resulting solution in 4 Stable overnight storage in a refrigerator at °C;

[0015] 2. Prepare β-glycerophosphate sodium solution: dissolve 0.5-0.7mol of β-glycerophosphate sodium (β-GP, β-glycerophosphate) in 4-7mL three-distilled water and mix well, and place the resulting solution in a refrigerator at 4°C Stable overnight storage;

[0016] 3. Prepare β-tricalcium phosphate / chitosan mixed solution: add 1.0~2.0% (w / w) β-tricalcium phosphate powder into the chitosan solution in the above-mentioned first step under continuous stirring, fully Stir for a certain per...

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Abstract

The invention relates to a novel preparation method of a composite bionic hydrogel. The described material is a beta-tricalcium phosphate / chitosan composite bionic hydrogel. The method comprises the steps of firstly dissolving chitosan by using a dilute acetic acid solution, dissolving beta-sodium glycerophosphate (beta-GP) into tri-distilled water, putting two parts of solutions into a refrigerator at 4 DEG C for storage overnight; adding beta-tricalcium phosphate to the chitosan solution under continuous stirring, carrying out ice-bath, adding a beta-GP solution, dropwise adding a little of glyoxal in a pH neutral environment, pacing the mixed solution at 37 DEG C overnight to form the hydrogel; and storing the hydrogel into the refrigerator at 4 DEG C to obtain the beta-tricalcium phosphate / chitosan composite bionic hydrogel material. According to the provided material, the part, requiring quick skeleton filling and bone tissue repairing, of an existing bone repair material is complicated, or an application limitation during minimally invasive therapy is overcome, and the preparation method is simple in process, low in cost and safe in synthesis, and has important application value in the field of biomedical engineering.

Description

technical field [0001] The invention relates to a preparation method of a novel composite biomimetic hydrogel, in particular to a preparation method of a β-tricalcium phosphate / chitosan composite biomimetic hydrogel. Background technique [0002] In the field of bone tissue repair biomedical engineering, the research on chitosan (chitosan) related materials has attracted much attention. Chitosan is obtained by N-deacetylation of chitin and is the only natural alkaline polysaccharide found so far. It has good biodegradability and biocompatibility, and also has the unique biological activity of selectively promoting the growth of epidermal cells and promoting the repair of bone tissue. As a good bone tissue biomedical engineering material, it is required that the material can be close to the composition of bone tissue and can provide a good extracellular biomimetic environment for bone tissue cells. The bone tissue of the human body is a composite structure formed by organic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/52
CPCA61L27/46A61L27/52A61L2430/02
Inventor 李玲
Owner JIANGNAN UNIV
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