Infantile autism biological marker and detection kit thereof

A technology of biomarkers and detection reagents, applied in the field of biomedicine, can solve the problems of low diagnostic accuracy, lack of blood diagnostic methods and effective treatment plans, etc.

Active Publication Date: 2017-09-15
深圳市英马诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Autism (ASD), as a kind of mental illness in children, seriously affects the children's social function and brings a heavy burden to the children's families and society. However, at present, autism is usually evaluated according to the scale,

Method used

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  • Infantile autism biological marker and detection kit thereof
  • Infantile autism biological marker and detection kit thereof
  • Infantile autism biological marker and detection kit thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] In this embodiment, ELISA is used to detect and analyze the stool samples of healthy people and patients with autism, and then perform statistical tests to determine the biomarkers related to the group of patients with autism. Specific steps are as follows:

[0078] 1. Sample source

[0079] Autism group: children with ASD from the Department of Psychology and Speech Therapy, Shenzhen Children's Hospital, collected from July to December 2015. Inclusion criteria: ①According to the latest international diagnostic criteria, that is, "Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, DSM-5", diagnosed as ASD "requiring a lot of support" Children; ②age <14 years old; ③gender is not limited. Exclusion criteria: ① suffering from other mental diseases (such as schizophrenia, etc.); ② suffering from other neurodevelopmental disorders; ③ suffering from genetic metabolic diseases; ④ suffering from severe neurological diseases and history of craniocerebral injur...

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Abstract

The invention provides an infantile autism biological marker, i.e., an IgA level in the intestinal tract, so that the diagnosis of the infantile autism can be judged without depending on the subjective experience, not only can the infantile autism be effectively early warned, but also the infantile autism can be diagnosed, and the diagnosis accuracy can be greatly improved. The invention also provides a kit for diagnosing the infantile autism. The kit comprises a reagent for detecting the infantile autism biological marker, and also comprises a tool for analyzing whether the infantile autism biological marker in the body is abnormal or not. The invention further provides a system for screening a biological sample susceptible to the infantile autism. By virtue of the screening system, the biological sample susceptible to the infantile autism can be screened.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular, the invention relates to autism biomarkers and detection kits thereof. Background technique [0002] Autism (ASD, Autism Spectrum Disorders), or autism or autism spectrum disorder, is a subtype of pervasive developmental disorders, more common in males, onset in infancy, mainly manifested in varying degrees of speech Developmental disorders, interpersonal communication disorders, narrow interests and rigid behaviors, about 3 / 4 of the patients are accompanied by obvious mental retardation. According to the US Centers for Disease Control and Prevention (CDC), the incidence rate in 2015 was 1 / 45 (ie 2.24%). my country still lacks national epidemiological survey data. If it is estimated at 1 / 100, it is estimated that there will be more than 10 million ASDs patients in my country. [0003] Autism (ASD), as a kind of mental illness in children, seriously affects the children's social functio...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6854G01N33/6893
Inventor 王明帮王艳周家秀杨争周少明何福生
Owner 深圳市英马诺生物科技有限公司
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