Analgesic and anti-inflammatory drug combination and preparation method and application thereof

A kind of technology of analgesic and anti-inflammatory, composition, applied in the field of analgesic and anti-inflammatory pharmaceutical composition and its preparation

Active Publication Date: 2017-11-03
辽宁华润本溪三药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, there is no report about the composition of saikosaponin D, paeoniflorin, corydalin and ammonium glycyrrhizinate for analgesic and anti-inflammatory

Method used

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  • Analgesic and anti-inflammatory drug combination and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The raw material composition of the analgesic and anti-inflammatory pharmaceutical composition of this example is: saikosaponin D 186.6g, paeoniflorin 138.1g, corydalin 75.2g, ammonium glycyrrhizinate 54.3g;

[0024] The preparation method of the pharmaceutical composition comprises the following steps: respectively taking selected weights of saikosaponin D, paeoniflorin, corydalin and ammonium glycyrrhizinate, and mixing them uniformly to obtain the product.

[0025] The analgesic and anti-inflammatory pharmaceutical composition of this example is prepared into granules by adding conventional excipients and following conventional techniques.

Embodiment 2

[0027] The raw material composition of the analgesic and anti-inflammatory pharmaceutical composition of this embodiment is: saikosaponin D 170g, paeoniflorin 152g, corydalin 68g, ammonium glycyrrhizinate 60g;

[0028] The preparation method of the pharmaceutical composition comprises the following steps: respectively taking selected weights of saikosaponin D, paeoniflorin, corydalin and ammonium glycyrrhizinate, and mixing them uniformly to obtain the product.

[0029] The analgesic and anti-inflammatory pharmaceutical composition of this example is made into a honeyed pill by adding conventional excipients and following a conventional process.

Embodiment 3

[0031] The raw material composition of the analgesic and anti-inflammatory pharmaceutical composition of this embodiment is: saikosaponin D 205g, paeoniflorin 125g, corydalin 82g, ammonium glycyrrhizinate 50g;

[0032] The preparation method of the pharmaceutical composition comprises the following steps: respectively taking selected weights of saikosaponin D, paeoniflorin, corydalin and ammonium glycyrrhizinate, and mixing them uniformly to obtain the product.

[0033] The analgesic and anti-inflammatory pharmaceutical composition of this example is prepared into a powder by adding conventional excipients and following a conventional process.

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Abstract

The invention specifically relates to an analgesic and anti-inflammatory drug combination and a preparation method and an application thereof. The drug combination consists of the following materials: 155 to 220 parts by weight of saikosaponin D, 110 to 168 parts by weight of paeoniflorin, 60 to 90 parts by weight of corydaline and 45 to 65 parts by weight of ammonium glycyrrhetate. Since the drug combination disclosed by the invention chooses the saikosaponin D, the paeoniflorin, the corydaline and the ammonium glycyrrhetate as materials, the materials cooperate with one another and jointly act under a specific proportion, and thereby the drug combination has a remarkable analgesic and anti-inflammatory effect; the drug combination has the remarkable analgesic and anti-inflammatory effect, the analgesic and anti-inflammatory effect is better than the analgesic and anti-inflammatory effect of any three of the four types of materials and the analgesic and anti-inflammatory effect of each of the four types of materials, and the drug combination has a synergistic effect.

Description

technical field [0001] The invention belongs to the field of medicines or health care products, and in particular relates to an analgesic and anti-inflammatory pharmaceutical composition, a preparation method and application thereof. Background technique [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of antipyretic and analgesic drugs widely used clinically. Since people extracted acetylsalicylic acid (aspirin) from willow bark to reduce fever, new members have been added to the non-steroidal family, and non-steroidal anti-inflammatory drugs have gradually become one of the most common drugs prescribed in the world. The antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects have been verified in many years of clinical practice. [0003] More and more studies have shown that natural medicine extracts and their derivatives have significant analgesic and anti-inflammatory effects, the representative ones are as follows: According to literatur...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/7048A61K31/4375A61K31/704A61P29/00
CPCA61K31/4375A61K31/704A61K31/7048A61K2300/00
Inventor孟宪生何晓霞袁际云韩凌包永睿潘英王帅李天娇
Owner辽宁华润本溪三药有限公司