Medicine composition for treating infantile precocious puberty and preparation method thereof

A composition and drug technology, applied in the field of compound traditional Chinese medicine, can solve the problems of patients’ inability to take long-term medication, unstable curative effect, difficulty in medication, etc., and achieve the effect of great curative effect, no toxic and side effects, and exact drug effect

Inactive Publication Date: 2017-11-07
ANGUO YADONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with the above three drugs may experience adverse reactions such as mild liver damage and mild hypertension
For these reasons, patients cannot take long-term medication, resulting in unstable curative effect
Moreover, Enatone and Dipherene are injections, which are difficult for children to use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The pharmaceutical composition for the treatment of precocious puberty in this embodiment is prepared by using the following raw materials in parts by weight: 1 gram of Rehmannia Radix; 999 grams of Alisma; 1 gram of Cortex Digus; 999 grams of Cortex Moutan; 1 gram of Gentiana; 999 grams of Prunella vulgaris; 1 gram of malt; 999 grams of turtle shell; 1 gram of chrysanthemum; 999 grams of kombu;

[0021] The preparation method of the pharmaceutical composition comprises the following steps: step 1, decocting the malt twice, combining the decoctions and filtering, adding an equal volume of ethanol to the filtrate, stirring the mixed solution overnight, taking the supernatant to recover the ethanol until it is free of alcohol taste, set aside; step 2, grind turtle shells and oysters into powder, put them into a cloth bag, add water to decoct with other medicinal materials for 3 times, combine the decoction and filter, obtain the filtrate and let it stand overnight; step 3,...

Embodiment 2

[0023] The pharmaceutical composition for the treatment of precocious puberty in this embodiment is prepared by using the following raw materials in parts by weight: Rehmannia 999 grams; Alisma 1 gram; Digupi 999 grams; Cortex Moutan 1 gram; Gentiana 999 grams; Prunella vulgaris 1 gram; 999 grams of malt; 1 gram of turtle shell; 999 grams of chrysanthemum; 1 gram of kelp; 999 grams of scrophulariae;

[0024] The preparation method of the pharmaceutical composition comprises the following steps: step 1, decocting the malt three times, combining the decoctions and filtering, adding an equal volume of ethanol to the filtrate, stirring the mixed solution overnight, taking the supernatant to recover the ethanol until it is alcohol-free taste, set aside; step 2, grind turtle shells and oysters into powder, put them into a cloth bag, add water to decoct them with other medicinal materials twice, combine the decoction and filter, obtain the filtrate and let it stand overnight; step 3, ...

Embodiment 3

[0026] The pharmaceutical composition for the treatment of precocious puberty in this embodiment is prepared by using the following raw materials in parts by weight: 25 grams of Rehmannia Rhizoma; 550 grams of Alisma; 100 grams of Cortex Digus; 320 grams of Cortex Moutan; 500 grams of Gentiana; 650 grams of Prunella vulgaris; 450 grams of malt; 300 grams of turtle shell; 150 grams of chrysanthemum; 300 grams of kombu;

[0027] The preparation method of the pharmaceutical composition comprises the following steps: step 1, decocting the malt four times, combining the decoctions and filtering, adding an equal volume of ethanol to the filtrate, stirring the mixed solution overnight, taking the supernatant to recover the ethanol until it is alcohol-free taste, set aside; step 2, grind turtle shells and oysters into powder, put them into a cloth bag, add water to decoct them with other medicinal materials for 4 times, combine the decoction and filter, obtain the filtrate and let it s...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating precocious puberty and a preparation method thereof. The pharmaceutical composition for treating precocious puberty in infants comprises the following raw materials: raw rehmannia, Alisma, Digupi, Moutan cortex, Gentiana, Prunella vulgaris, malt, turtle shell, chrysanthemum, kelp, scrophulariaceae, Gallus gallis, and oyster. The preparation method of the pharmaceutical composition comprises the following steps: S1, decocting malt for 2 to 5 times, combining the decoctions and filtering, adding an equal amount of ethanol to the filtrate, stirring the mixture and standing overnight, taking the supernatant and recovering the ethanol until free Alcoholic taste, set aside; S2, grind turtle shells and oysters into powder, put them into a cloth bag, add water to decoct with other medicinal materials for 2-5 times, combine the decoction and filter, obtain the filtrate and let it stand overnight; S3, take S2 The supernatant of the filtrate is added to the supernatant of S1 and filtered, and the pharmaceutical composition is obtained through post-processing. The invention has the effects of clearing liver and dispelling stagnation, nourishing yin and purging fire, can treat young girls' breast distension and pain and vaginal bleeding, and has the effect of treating children's precocious puberty.

Description

technical field [0001] The invention belongs to the technical field of compound traditional Chinese medicines, in particular to a pharmaceutical composition for treating precocious puberty in infants and a preparation method thereof. Background technique [0002] Precocious puberty is a common developmental abnormality of the pediatric endocrine system, which refers to the abnormal development of secondary sexual characteristics in girls before the age of 8 and boys before the age of 9. Female manifestations include breast development, enlargement of labia minora, estrogen-dependent changes in vaginal mucosa cells, enlargement of uterus and ovaries, appearance of pubic hair, and menarche. In men, the testicles and penis enlarge, pubic hair appears, muscles develop, and the voice becomes thicker. Both sexes have accelerated growth and accelerated bone maturation, which can eventually lead to a lifetime height below the target height. When associated with central nervous s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61P15/00A61P15/14A61P15/02A61P7/04A61P43/00A61P5/24A61K35/57A61K35/586A61K35/618
CPCA61K36/804A61K35/57A61K35/586A61K35/618A61K36/03A61K36/287A61K36/515A61K36/536A61K36/65A61K36/71A61K36/808A61K36/815A61K36/884A61K36/8998A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 付立家付建家马筠赵敏姿
Owner ANGUO YADONG PHARMA
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