20 results about "Early puberty" patented technology

The invention provides an application of Fuxia dothidei YG0564 in preparation of a composition for preventing, relieving and / or treating individual sexual precocity, growth and development impairment and / or obesity. It is found that the Fuxia dolferi YG0564 can effectively prevent, relieve and / or treat sexual precocious puberty, growth and development damage and / or obesity of individuals, and especially has a remarkable improvement effect on the diseases caused by high-fat diet. For sexual precocious puberty or damaged growth and development induced by high-fat diet, the Fuxia dolferi YG0564 is applied to individuals in the early stage or early stage of puberty, the protection effect of the Fuxia dolferi YG0564 can be continued to the adult stage, and the fundamental problem of growth and development is solved through staged medication. Therefore, a potential probiotic treatment scheme is provided for precocious puberty, growth and development damage and / or obesity of individuals, and the probiotic composition is convenient to apply, high in patient acceptability and low in treatment cost, so that the probiotic composition has good clinical transformation value and social benefits.

The application discloses a kind of substance for preparing the use of reagent for treating individual precocity and its application, by large-scale sample analysis work, the application first discovers a kind of biomarker for predicting individual precocity, i.e. 6-position hydroxyl bile acid, and verifies its effectiveness as biomarker;Provide a kind of method for treating individual precocity, i.e. reduce the concentration of 6-position hydroxyl bile acid, for example, by reducing the concentration of 6-position hydroxyl bile acid cholestyramine to treat precocity;In-depth study of related mechanism, the correlation between TGR5 receptor and precocity is found, i.e. inhibit TGR5 receptor or prevent TGR5 receptor from being activated, prevent GnRH expression from being promoted, to treat individual precocity;Provide a kind of reagent composition for treating individual precocity, use cholestyramine or other reagents for reducing the concentration of 6-position hydroxyl bile acid, reagents for promoting 6-position hydroxyl bile acid metabolism, TGR5 receptor inhibitor etc. are intervened, to treat individual precocity.

The invention relates to the technical field of biomedical detection, in particular to a rapid detection method for a specific biomarker of precocious puberty of central girls. When a blood sample is detected, an original light intensity sequence of the chromatographic test strip is obtained and adjusted into a standardized net signal sequence; the color band width is controlled by the chromatography flow velocity and can reflect the fluid diffusion level under the sample viscosity, so that the quality control line reference width and the waveform sharpness are determined, and the waveform distribution characteristics are grasped; if the blood viscosity is increased, the light intensity of quality control and interference capture intervals is distorted, and when the light intensity of the interference capture intervals meets preset conditions, saturation evaluation indexes are determined according to peak shape characteristics and quality control line related parameters of the interference capture intervals, and the saturation degree is evaluated; analyzing the light intensity in a membrane gap interval to obtain a background trailing ratio, and quantifying the leakage flux of free interferents; finally, the saturation evaluation index and the background trailing ratio are fused to obtain a blood sample effective value, the sample condition can be comprehensively and accurately reflected, and whether the sample is suitable for detection or not can be determined.

The present invention relates to a method, apparatus, and computer program for predicting precocious puberty for each stage of growing children and adolescents using an artificial intelligence model. The method for providing precocious puberty prediction and solution for each growth stage using artificial intelligence includes: receiving time series physical information on an evaluation subject; classifying a plurality of growth stages based on the input physical information on the evaluation subject, and then extracting physical information corresponding to a normal growth stage among the plurality of growth stages; predicting precocious puberty by inputting the extracted physical information to a trained neural network; and providing a precocious puberty management solution based on the physical information on the evaluation subject when the evaluation subject corresponds to the precocious puberty.

The invention relates to the technical field of molecular markers, and discloses an SNP molecular marker related to chicken premature traits and application of the SNP molecular marker in breeding, the SNP molecular marker related to chicken premature traits is a single nucleotide polymorphism site in a chicken CHADL gene and comprises a site 1, a site 2, a site 3, a site 4, a site 5, a site 6, a site 7, a site 7, a site 7, a site 7, a site 8, a site 7, a site 8, a site 7, a site 8, a site 7, and a site 7, the site 2 is located at the site g.49793806 of the chromosome 1, and the base variation is C / T; the site 3 is located at the site g.49794002 of the chromosome 1, and the base variation is C / T; the site 4 is located at the site g.49794431 of the chromosome 1, and the base variation is C / T; the site 5 is located at the site g.49794441 of the chromosome 1, and the base variation is A / G; the site 6 is located at the site g.49795003 of the chromosome 1, and the base variation is C / T; the site 7 is located at the site g.49797766 of the chromosome 1, and the base variation is A / G; the site 8 is located at the site g.49798159 of the chromosome 1, and the base variation is T / G. The SNP molecular marker can accurately show chicken prematurity related traits.

The invention provides a gene influencing sexual precocity of deep-county pigs and a screening method thereof, and belongs to the field of research on sexual maturity of pigs, the gene influencing sexual precocity of deep-county pigs comprises an SRD5A1 gene and / or a CYP11B2 gene, testicular tissues of deep-county pigs before and after sexual maturity are subjected to transcriptome sequencing, differential expression gene functions are analyzed, and the sexual precocity of deep-county pigs before and after sexual maturity is obtained. And screening out candidate genes related to the sexual maturity of the deep county pigs. And then performing transcriptome sequencing on testis tissues of the sexually mature deep county pig and the hybrid pig of the sexually mature deep county pig and the large white pig, analyzing functions of differential expression genes, and screening specific expression genes of the sexual maturity of the deep county pig. Integrating the results of the two times of transcriptome sequencing, analyzing the functions of the coincident genes, and screening candidate genes SRD5A1 and CYP11B2 which influence the sexual precocity of the pigs in the deep county according to the gene functions; and a foundation is laid for subsequent research on precocious puberty of pigs in deep county.

This invention relates to the field of physiological data analysis technology for precocious puberty, specifically to a method and system for risk analysis of patients in the early stages of precocious puberty. The invention obtains the degree of dimensional deviation based on the distribution of patient data in each dimension across all data, thereby screening out similar patient groups; it obtains the degree of individual difference based on the similarity and correlation between patients and similar patient groups in each dimension; it obtains the degree of precocious puberty tendency in each dimension based on the proportion of patients in similar patient groups within the data of each dimension; it screens out dimensions with minor differences based on the degree of individual difference, thereby obtaining model error terms; and it uses the degree of individual difference, the degree of precocious puberty tendency, and the model error terms to obtain a regression model for precocious puberty risk analysis, and performs risk analysis on patients with precocious puberty. This invention can greatly reduce the computational complexity and noise interference of the precocious puberty risk analysis regression model, thereby obtaining accurate risk analysis results.

The application discloses a kind of pediatric growth promoting preparation, belong to the technical field of traditional Chinese medicine preparation, including Fructus Schisandrae, radix pseudoginseng, dried ginger, angelica, amomum villosum, incense, dried tangerine or orange peel, June snow, Chir Chir, dog spine, and cow bone powder.The preparation of the present application combines the theory of traditional Chinese medicine for invigorating the spleen and kidney, regulating qi and blood, wherein Fructus Schisandrae, radix pseudoginseng, dried ginger and the like can invigorate the spleen and stimulate appetite, significantly improve the digestive function and improve the absorption rate of nutritional substances;Amomum villosum and amomum villosum regulate the middle-jiao qi movement, relieve abdominal distension and stagnation of qi, and further optimize the absorption state;Chir Chir, dog spine and cow bone powder directly act on the skeletal system, tonify the kidney and strengthen the bone, promote chondrocyte proliferation and longitudinal growth of the skeleton, and effectively improve the height growth speed.The formula takes into account the intervention of growth disorders such as precocious puberty, delays the bone age through the bidirectional regulation of nourishing yin and purging fire and tonifying the kidney and filling essence, and gains valuable time for height growth.

The invention discloses a traditional Chinese medicine composition for treating children sexual precocity and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials: vinegar-processed bupleurum chinense, radix paeoniae rubra, thunberg fritillary bulb, bran-fried fructus aurantii, uncaria rhynchophylla, cicada slough, calcined oyster shell, cornu cervi degelatinatum, fried scutellaria baicalensis, fructus forsythiae, liquorice, vinegar-processed turtle shell, rhizoma anemarrhenae, golden cypress, gordon euryale seed, bran-fried cortex ailanthi, radix rehmanniae recen, moutan bark, warm Chinese yam and rhizoma alismatis. The traditional Chinese medicine composition is derived from clinical practice accumulation of Xixi hospital in Hangzhou, and is typical application of the traditional Chinese medicine syndrome differentiation and treatment theory in pediatric endocrine disease treatment. The formula strictly follows the traditional Chinese medicine core principle of'cause solving through verification and dialectical treatment ', all the components form an organic whole in the medicine effect level through accurate raw material screening and scientific dosage matching, the unique effect of a single medicinal material can be played, the synergistic interaction effect of' 1 + 1 > 2 'can be achieved through mutual coordination and mutual promotion, and the traditional Chinese medicine composition has a good application prospect. A very valuable solution is provided for treating the sexual precocious puberty of children.

This application relates to the biomedical field and discloses the use of hypothalamic paternal IGF2 as a biomarker in the preparation of products for screening and preventing precocious puberty. Specifically, it discloses the application of reagents for detecting the gene imprinting status and / or expression level of hypothalamic paternal insulin-like growth factor 2 in the preparation of precocious puberty screening products, and the application of substances that inhibit the activation of hypothalamic paternal insulin-like growth factor 2 or reduce its expression level in the preparation of drugs for preventing and treating precocious puberty. This application establishes a link between paternal IGF2 and BPA and high-nutrition-induced precocious puberty for the first time, clarifying its core role in mediating the occurrence of precocious puberty and its early warning value, breaking through the limitations of traditional precocious puberty mechanism research. The proposed intervention program is both specific and practical. Among them, the application of Dabu Yin Wan (a traditional Chinese medicine formula) achieves precise targeting of traditional Chinese medicine in the intervention of precocious puberty, and compared with existing intervention technologies, it has significant advantages such as fewer side effects, strong targeting, and high operability.

A sustained-release microsphere containing a drug, pamoic acid, and a biocompatible polymer, a pharmaceutical composition containing the sustained-release microsphere for prevention, improvement, or treatment of hepatitis B, prostate cancer, breast cancer, endometriosis, uterine fibroid, precocious puberty, acromegaly, gastro⋅entero⋅pancreatic endocrine tumor, Alzheimer's disease, or cognitive disorder, and a preparing method of the sustained-release microsphere are provided.

The application discloses a self-destroying syringe for treating children's precocious puberty, relates to the field of treating children's precocious puberty and comprises a plunger barrel, a plunger rod arranged in the plunger barrel, an injection needle arranged at the bottom of the plunger barrel and a self-destroying trigger device sleeved outside the plunger barrel, wherein the plunger barrel comprises two semicircular plunger barrels connected with a cylindrical body at one side outer wall, and the two semicircular plunger barrels are clamped with the injection needle in a folded state; the self-destroying trigger device comprises a split power component arranged at the side of the semicircular plunger barrel away from the cylindrical body, a U-shaped frame sleeved outside the semicircular plunger barrel, a split limiting component arranged at the side of the U-shaped frame close to the split power component and a one-way moving component; the bottom of the U-shaped frame is provided with a needle retraction power component, the outer wall of the U-shaped frame is slidably connected with a moving plate, and the outer wall of the moving plate is connected with the cylindrical body. The syringe integrates a reliable one-time self-destroying mechanism on the basis of the conventional injection function and can effectively avoid repeated use.

The present invention belongs to the technical field of medical products, and specifically provides a nutritional composition for preventing and / or treating precocious puberty in children. Proteins in the nutritional composition of the present invention are derived from high-quality proteins such as soy protein and whey protein, which are provided to help the growth and development of children. Among these, the soy protein, as a high-quality plant-based protein, can delay puberty and is negatively correlated with the percentage of body fat, and further inhibits precocious puberty by preventing obesity. In addition, dietary fibers from good sources such as fructo-oligosaccharides and galacto-oligosaccharides are added to the nutritional composition. The intake of high dietary fibers is associated with a later age at menarche, and more dietary fibers can delay the timing of pubertal development. By controlling the ratio of the soy protein to the dietary fibers at 3:1 to 5:1, the composition achieves efficacy in preventing precocious puberty in children.

This invention belongs to the field of aquaculture technology, specifically relating to a plant-derived compound preparation for controlling precocious puberty in giant freshwater prawns, its preparation method, and its application method. The plant-derived compound preparation comprises the following raw materials in parts by weight: 1.5–3.0 parts gardenia extract, 0.5–1.2 parts quince extract, 0.5–1.0 parts mulberry leaf extract, 0.5–1.2 parts lily extract, 1.0–2.5 parts dried ginger extract, and 90–98 parts vitamin B complex powder. The plant-derived compound preparation is added to the feed of giant freshwater prawns at specific growth stages and simultaneously sprinkled into the aquaculture water. Through surface penetration and absorption, it regulates and improves hepatopancreatic function, enhances nutrient digestion and conversion, promotes growth, and reduces the probability of precocious puberty, thus replacing existing control measures. The technical solution of this invention has the characteristics of good and stable control effect, small dosage, convenient use, and high safety, ensuring the size and yield of marketable prawns, thereby achieving the goal of rationally controlling the density of giant freshwater prawns in ponds and improving aquaculture efficiency.

The invention discloses a traditional Chinese medicine composition for treating child development retardation and bone age abnormity and application thereof, and belongs to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises the following raw materials by weight: 8-20 parts of radix fici simplicissimae, 4-15 parts of bighead atractylodes rhizome, 4-12 parts of radix clematidis, 8-18 parts of Chinese angelica, 5-16 parts of teasel root, and 5-16 parts of white peony root; the invention further discloses a preparation method and application of the traditional Chinese medicine composition. According to the invention, through three-dimensional linkage of tonifying spleen and kidney to consolidate foundation and fire, nourishing qi and blood to charge sources and dredging meridians and collaterals to improve efficiency, the core targets of inhibiting abnormal bone age progression, promoting growth and strengthening muscles and bones are achieved. Wherein the radix clematidis has the characteristics of dredging meridians and removing bone sticking and can assist in regulating bone metabolism and dredging the drug efficacy path. The composition has the effect of clinically inhibiting the bone age abnormal progress caused by precocious puberty, and becomes a characteristic synergistic key for treating the dwarf disease and inhibiting the bone age abnormal progress. The whole formula gives consideration to inhibition of pathological bone age development and excitation of physiological growth potential, and a traditional Chinese medicine solution for treating both symptoms and root causes is provided for children with growth and development disorders.

Disclosed are compositions and methods including Anti-Müllerian Hormone (AMH) receptor binding peptides. The AMH receptor binding peptides can be used, for example, to modify the activity of the AMH receptor. For example, the AMH receptor binding peptides can activate the AMH receptor, such as the AMH receptor 2, thereby mimicking the function of AMH. In other examples, the AMH receptor binding peptides function as AMH receptor antagonists, thereby interfering with the function of endogenous AMH. By modifying the activity of the AMH receptor, the peptides have multiple applications, including for example modification of treatment of precocious puberty in females, delay of natural menopause, preservation of ovarian follicular reserve, contraception, fertility preservation after ovarian cortex transplant, treatment of endometriosis, treatment of cancer and / or cancer prevention, and treatment of polycystic ovary syndrome (PCOS).

The invention discloses a self-destruction syringe for treating precocious puberty of children, which relates to the field of treatment of precocious puberty of children and comprises a plunger barrel, a plunger rod arranged in the plunger barrel, a syringe needle arranged at the bottom of the plunger barrel and a self-destruction trigger device sleeved outside the plunger barrel. The plunger barrel body comprises two semicircular plunger barrels, the outer walls of one sides of the two semicircular plunger barrels are connected with the cylinder, and the two semicircular plunger barrels are clamped with the injection needle in a folded state; the self-destruction triggering device comprises a split power part arranged on the side, away from the cylinder, of the semicircular plunger barrel, a u-shaped frame arranged outside the semicircular plunger barrel in a sleeving mode, a split limiting part arranged on the side, close to the split power part, of the u-shaped frame, and a one-way moving part; a needle retraction power component is arranged at the bottom of the u-shaped frame, the outer wall of the u-shaped frame is slidably connected with a moving plate, and the outer wall of the moving plate is connected with the cylinder. On the basis of a conventional injection function, the injector is integrated with a reliable disposable self-destruction mechanism, and repeated use can be effectively avoided.

The invention discloses application of aucubin in treatment of sexual precocity. According to the application, a precocious puberty mouse model is firstly constructed, in a Balb / c mouse precocious puberty model induced by a low dose of BPA, aucubin intervention can significantly down-regulate expression of key genes KISS1 and GnRH1 in hypothalamic development regulation and central development regulation, reduce the level of sex hormone in peripheral blood, delay ovarian development, and inhibit hypothalamic development regulation and central development regulation. The vaginal opening time (body surface marks of rodent model sexual development initiation) is delayed, so that sexual precocious puberty is treated. The invention provides a new medicine scheme for treating precocious puberty, provides a new thought for research and development of precocious puberty treatment medicines, and expands the application range of aucubin.

The present application relates to a kind of gonadotropin releasing hormone antagonists, it has the antagonistic activity to gonadotropin releasing hormone, and can be used to prevent or treat sex hormone-dependent diseases, such as benign prostatic hypertrophy, uterine fibroids, endometriosis, uterine fibroids, precocious puberty, amenorrhea, premenstrual syndrome, dysmenorrhea and the like, or its prodrug, or its pharmaceutically acceptable salt, or its hydrate or solvate, and the pharmaceutical composition containing it.