73 results about "Early puberty" patented technology

The present compounds are intermediates for the preparation of quinoline derivatives and compositions having gonadotropin-releasing hormone antagonistic activity useful as propylactics or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine or cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals, and as agents for promoting spawning in fish.

The invention relates to milk chrysanthemum (chrysanthemum rice) tea and a processing method thereof. The milk chrysanthemum (chrysanthemum rice) tea is characterized in that the raw material of the chrysanthemum tea is the flower buds of chrysanthemum which are already formed and are not open. The processing method is characterized by comprising the following steps: picking the flower buds of the chrysanthemum which are already formed and not open as the raw material, sieving the raw material, classifying according to the size, cleaning by clear water, steaming by the steam of a circular disk bamboo steamer, fixing, afterwards drying twice, taking out after drying once, and putting at room temperature for 30-48 hours and then secondary drying after softening. Because the chrysanthemum in early puberty is adopted as the raw material, the invention has the following advantages: (1) fruits are fresh and tender, nutritional components are high, and the mouth feel is better than that of the chrysanthemum with opening flower buds and completely opened petals; (2) the raw material is not easily polluted by dust in air, pesticide and harmful chemical components in the face of opening or florescence; and (3) the drying of the processing method is carried out by two sections, and the phenomena of softening, easy discoloration, yellowing and mouldy change of a finished product of tea in the prior art are overcome.

The present invention relates to an excellent-quality chicken maternal strain, in particular to a method for the strain breeding of the dark-shank spotty plumage chicken with dwarf gene, which belongs to the technical field of the dark-shank spotty plumage chicken with dwarf gene. The breeding procedures of the present invention are (1) selecting a cock of Chongren chicken and a hen having the dark-shank partridge in the grandparent hen group of the dwarf yellow-feather chicken as the breeding materials and selecting a normal-shaped cock having the dark-shank partridge character in the F1 generation after the hybridization of the cock and the hen; (2) Selecting the dark-shank partridge normal-shaped cock to be mated with the hen of the dark-shank partridge dwarf yellow-feather chicken and selecting the dark-shank partridge dwarf cock and the dark-shank partridge dwarf hen in the F2 generation; (3) cross-breeding and locking the selected dark-shank partridge dwarf cock and the dark-shank partridge dwarf hen so as to get the present invention after the breeding from generation to generation. Since the body of the maternal-strain chicken is short cultivated through the present invention, the chicken has the outstanding advantages of precocious puberty, high-yield of eggs and less feed consumption and cultivated space saving, which greatly reduces the production cost of the commodity generation chicken and improves the comprehensive benefit of the cultivation.

The present invention is directed to the controlled delivery of gonadotropin-releasing hormone (GnRH) agonists, preferably from a polymeric material that is implanted in the body. More specifically, the present invention relates to compositions comprised of a GnRH agonist, preferably histrelin, in a polymeric material that results in a desired and controlled delivery of a therapeutically effective amount of GnRH agonist over an extended period of time in order to treat central precocious puberty (CPP).

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The present invention relates to a novel class of AKR1C3 inhibitors, to compositions containing them, to methods for their preparation, and to methods of use thereof. The AKR1C3 inhibitors may be useful in the treatment of, for example, prostate cancer, benign prostate hyperplasia (BPH), lung cancer, acne, seborrhea, hirsuitism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, uterine cancer, uterine fibroids, endometriosis, myeloma and leiomyoma.

The invention discloses a method for cultivating large 3-age river crabs, which comprises the steps of selecting cultivation water areas, selecting and transporting pea crabs, primarily cultivating crab species, cultivating large crabs, cultivating the 3-age river crabs and the like. The method for cultivating the large 3-age river crabs relies on a matured juvenile-crab cultivating and adult-crab breeding technology at present, and the pea crabs are moved to high altitude areas to be cultured. By utilizing special natural conditions suitable for the river crab to grow in the high altitude areas, the pea crabs are cultivated into large crab species which are intensively cultivated in southern ponds, and the purpose of cultivating the large adult crabs is achieved accordingly. The problem that the size of the cultivated adult crabs is not ideal due to the germplasm problem is effectively solved, the problem that the adult crabs and the crab species have precocious puberty in the cultivating and breeding process is solved, the large-scale production of the cultivated large adult crabs can be achieved, and the economic benefit of river crab cultivation is further improved. In addition, the method for cultivating the large 3-age river crabs is simple in implementation, and the adult crabs cultivated by means of the method is larger than adult crabs cultivated by means of a common cultivating method.

The present invention relates to a method and composition for use in treating a condition that benefits from the reduction of hepatic and / or visceral fat, such as polycystic ovary syndrome in adolescent girls or women of childbearing age, involving the use of spironolactone, pioglitazone and metformin.

To provide a novel and excellent method for treating and / or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5.It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and / or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and / or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and / or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.

The invention discloses an SNP locus significantly relevant to the precocious puberty trait of eriocheir sinensis and the application. The SNP locus is positioned in a Vg gene 5'-flanking region-437bpposition of the eriocheir sinensis, and nucleotide variation information is SNP g.-437T) G. PCR primer used for detecting the SNP locus is SEQ ID NO.1 and SEQ ID NO.2, and restriction enzyme is MboI.The SNP locus has significant correlation with precocious puberty of the eriocheir sinensis, and the risk of precocious puberty trait of GG gene eriocheir sinensis individual is obviously smaller than that of precocious puberty trait of TT gene individual. The SNP locus and the PCR primer used for genetic typing are applied to the predication of the risk of precocious puberty of the eriocheir sinensis and / or the variety breeding of the eriocheir sinensis.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e,g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea sydrome, multilocular ovary sydrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The present invention discloses a eukaryotic expression method of molt-inhibiting hormone-1 gene of mitten crab, including the steps of constructing a eukaryotic expression vector of the molt-inhibiting hormone-1 gene of the mitten crab and eukaryotic expressing molt-inhibiting hormone-1 gene of the mitten crab. The eukaryotic expression method successfully expresses an MIH protein; provides a theoretical basis for further understanding the internal mechanism of the precocious crab gonad early development, understanding the function mechanism of the crab molt gland, and further establishing technical measures to control crab precocious puberty; and obtains artificial regulation basis of achieving growing development and reproduction.

The invention discloses a living molecular detection method for precocious puberty individual of Eriocheir sinensis. Full-length cDNA sequence of EsEcR gene is cloned from Eriocheir sinensis tissue by the use of primer groups provided by the invention. Based on the gene sequence, the invention provides a living molecular detection method for precocious puberty individual of Eriocheir sinensis. The invention not only provides a living molecular detection method for precocious puberty individual of Eriocheir sinensis, but also provides an important testing method for early detection of Eriocheir sinensis precocious puberty individual.

The compounds of the present invention possess excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

Biphenyl derivatives are disclosed for use in the treatment of androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, precocious puberty, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and premature male baldness. For example, some preferred compounds having the structure: are formulated together with pharmaceutically acceptable diluent or carrier for topical use in the treatment of acne, hirutism, seborrhea or androgenic alopecia, or for systemic use in the treatment of androgen-dependent prostate cancer.

The invention discloses peach leaf and flower tea and a preparation method thereof. The peach leaf and flower tea consists of peach leaves, peach flowers and rose. Fresh and tender peach leaves and peach flowers during blossoming of peach flowers before and after the Tomb-sweeping Day every year are collected at first, after processes of manual leaf picking, flower picking, fixation, stacking, flower forcing, twisting, micro-fermentation, screening, roasting, scenting, fragrance improving and the like, a peach leaf tea beverage which is processed from the peach leaves is obtained. Scenting is mainly carried out in the flower season, fresh roses which are large and full, have plump petals, are bright and red in color and are in early puberty on that day are picked, the roses are paved, the petals are folded, flower bases and stamen are removed, and the petals are subjected to scenting. The peach leaf and flower tea is subjected to scenting by first-class rose petals, and therefore, full-bodied fragrance of the peach leaf and flower tea is improved. The peach leaf and flower tea is bitter and dry, has gentle characters and flavor, is good in sensory quality and bright in color, has effects of improving looks and nourishing the skin, reducing weight and relieving constipation, relieving uneasiness of mind and the like, and has a good regulation effect on high-heat, high-fat and high-sugar-content dietary habit of modern people.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc. or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The invention discloses a microsatellite-labeled primer linked with precocious puberty or no precocious puberty of eriocheir sinensis and application thereof. The microsatellite-labeled primer is characterized in that 5 pairs of microsatellite primers are provided, wherein 2 microsatellite sites are linked with the precocious puberty character of the eriocheir sinensis; 3 microsatellite sites are linked with the normal character of the eriocheir sinensis; the primer can be used for identifying whether the eriocheir sinensis has the precocious puberty. The specific identification method comprises the following steps of: taking DNA of a gene group of the eriocheir sinensis to be identified, then carrying out PCR (Polymerase Chain Reaction) augmentation by 5 pairs of microsatellite primers, respectively carrying out polyacrylamide gel electrophoresis on augmentation products, then carrying out silver dyeing staining, and judging the condition of the precocious puberty of the eriocheir sinensis to be identified by the size of strips at different positions. The microsatellite-labeled primer and the application disclosed by the invention have the advantages that normal individuals without precocious puberty can be selected for culture in a targeted manner, so that the normal individuals can be prevented from mixing the young eriocheir sinensis of precocious puberty in the process of early culture, and the development of the eriocheir sinensis in China can be effectively improved.

The invention relates to a traditional Chinese medicine composition for treating child precocious puberty. The traditional Chinese medicine composition is characterized by consisting of the following medicines in parts by weight: radix bupleuri, scutellaria baicalensis, dried tangerine or orange peel, rhizoma pinelliae preparata, poria cocos, fructus aurantii, caulis bambusae in taeniam, oriental wormwood, monkshood, codonopsis pilosula, bighead atractylodes rhizome, rhizoma zingiberis, stiff silkworm, ground beetle, manis pentadactyla, vinegar turtle, stir-frying tortoise plastron with vinegar, cicada slough, angelica sinensis, calcined oyster shell, white paeony root, honey-fried licorice root, fructus amomi, golden cypress, Chinese yam, ginkgo seed, Chinese fevervine herb and root, rehmannia glutinosa, radix asparagi, gorgon fruit, radix ophiopogonis and schisandra chinensis. The medicine has the effects on soothing the liver, tonifying the spleen, removing dampness, tonifying the kidneys and yin, reducing ministerial fire, reducing phlegm, resolving masses and eliminating stagnation, is suitable for treating the child precocious puberty with multiple syndrome types such as kidney yin deficiency, liver depression dampness-heat, phlegm-heat obstruction and the like, and is obvious in clinical treatment effect. The cure rate is over 55 percent, the total effective rate is over 95 percent, and the traditional Chinese medicine composition has the characteristics of good curative effect, short course of treatment, complete curative effect, no side effect and the like.

The invention relates to a composition, which is prepared by taking fructus hordei germinatus as a sovereign drug and cooperatively using one or more of radix lithospermi, herba cistanche, rhizoma drynariae, semen coicis, bighead atractylodes rhizome, pericarpium citri reticulatae, fructus amomi rotundus, spica prunellae, bulbus fritillariae thunbergii, and the like. The composition is prepared according to the physiological and pathological features of 'frequent deficiency of spleen, frequent excess of liver and frequent deficiency of kidney' of children as well as a close relation between child precocious puberty and visceral organs such as spleen, liver and kidney. The composition provided by the invention can delay and cure the development of all characteristics of precocious puberty of patients, and enables the patients haveno withoutnot to have obvious change before and after treatment. Furthermore, the composition also has an obvious curative effect on delaying bone age growth,thus effectively improving the heights of the patients in adulthood.

The invention provides a fresh flower nutritional healthcare beverage and a preparation method thereof. The preparation method comprises the steps of: selecting pollution-free edible fresh flowers in early puberty, removing calyxes, reserving petals and pistils, soaking in mineral water, pulping, adding a proper amount of mineral water, evenly agitating, filtering to obtain fresh flower juice, then blending by using natural fruit acid and honey and finally conducting pasteurization to obtain the finished product. The fresh flower beverage has the efficacies of moistening skins, beautifying appearance, conditioning vital energy and blood and reliving emotion, and has a very high nutritional and healthcare value.

The invention relates to a method for extracting jasmine essential oil. The method comprises the following steps: (1) flower picking, picking fresh jasmine in an air-conditioned room, uniformly spreading, culturing the flowers to 22:00 to 24:00 in order that the jasmine is in early puberty for later use; (2) fragrance pumping, placing the jasmine which is in the early puberty into a jasmine fragrance extraction device, adsorbing the jasmine fragrance through an active carbon adsorbent in the jasmine fragrance extraction device for later use; (3) extracting, placing the active carbon adsorbentby which the jasmine fragrance is adsorbed into an extraction tank, inflating the CO2 into the extraction tank for performing CO2 ultra-critical extraction to obtain the jasmine essential oil for later use; (4) heating the jasmine essential oil prepared in the step (3) to the temperature of 100 DEG C or more, evaporating water vapor to obtain the jasmine essential oil. The jasmine essential oil has the characteristics of good effect, high yield, high purity and the like.

Spiroindoline derivatives, processes for their preparation and pharmaceutical compositions thereof, their use for the treatment of diseases, and their use for the manufacture of medicaments for the treatment of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine leiomyoma (fibroids), polycystic ovarian disease, menorrhagia, dysmenorrhea, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception, infertility and assisted reproductive therapy such as in vitro fertilization. The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, pplycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The invention provides a production method of Oncorhynchus Mykiss triploid fry. The production method including fertilizing fertilized eggs of Oncorhynchus Mykiss for 12-14 min at the temperature of 7 DEG C to transfer to 240mg / L 6-DMAP (6-Dimethylaminopurine) solution at temperature at 12-14 DEG C for soaking for 14-16 min, and then transferring the fertilized eggs to hatching water to hatch normally. After around 50 days, the Oncorhynchus Mykiss triploid fry are hatched from the fertilized eggs. Eyeing rate of the fertilized eggs during hatching is more than 68%, hatching rate of the fry reaches 90%, the fry are detected by a flow cytometry, rate of triploid reaches 81%. By the aid of the production method of the Oncorhynchus Mykiss triploid fry, the problems of precocious puberty, individual miniaturization, disease breeding and the like on cultivation individuals due to long-term inbreeding and lack of systematic select breeding during cultivation of the Oncorhynchus Mykiss, and the production method has good market value.

The invention discloses a medicine composition for treating infantile precocious puberty and a preparation method thereof. The medicine composition is prepared from the following medicinal raw materials: radix rehmanniae recen, rhizoma alismatis, cortex lycii radicis, moutan bark, felwort, selfheal, malt, turtle shell, chrysanthemum, kelp, radix scrophulariae, endothelium corneum gigeriae galli and oyster. The preparation method comprises the following steps: S1, decocting malt for 2-5 times, mixing the decoctions, filtering; adding alcohol which has equal amount as the filtrate into the filtrate, stirring the mixed solution, and standing overnight; reclaiming alcohol from the supernate until no alcohol smell exists; S2, grinding turtle shell and oyster into powder, filling cloth bags with the powder, and decocting together with other medicinal materials with water for 2-5 times, mixing the decoctions, filtering, and standing the filtrate overnight; and S3, taking the supernate of the filtrate in the S2, adding the supernate into the S1, filtering, and performing post processing to obtain the medicinal composition. The medicine composition has the effects of clearing liver, eliminating stagnation, nourishing yin and purging internal fire, can be used for treating infantile breast distending pain and vaginal bleeding, and has the effect of treating infantile precocious puberty.

The invention discloses a medicine composition for treating sexual precocity and application of the medicine composition. The medicine composition is prepared by the following Chinese crude drugs in part by weight: 11-17 parts of dried rhizome of rehmannia, 18-30 parts of raw oyster, 8-13 parts of hairyvein agrimony, 8-13 parts of marine alga, 9-16 parts of fiveleaf akebia fruit, 9-16 parts of Chinese holly leaves, 5-10 parts of Chinese tamarisk tops, 4-8 parts of polygala roots and 4-8 parts of Flos Magnoliae Officinalis. The medicine composition has effects of nourishing kidney-yin and reducing ministerial fire; when the medicine composition is used for treating sexual precocity, signs and symptoms can be improved effectively; the medicine composition is suitable for treating sexual precocity of girls suffering from low-grade or medium-grade sexual precocity; a clinical therapeutic effect is obvious and course of treatment is short; and the medicine composition takes effect quickly, is safe and does not have toxic or side effects.