A Multi-Nuclide Multi-Frequency Resonance Simultaneous Imaging System

Abstract

The invention provides a multi-nuclide multi-frequency resonance synchronous imaging system which is used for detecting the tumor ion dynamic balance, the energy metabolism, the molecular target change and the tumor microenvironment change. The system can simultaneously transmit radio frequency pulse signals corresponding to four nuclides of 1H, 23Na, 31P and 19F and synchronously receive the nuclear magnetic resonance load signals of the four nuclides. The multi-nuclide multi-frequency resonance synchronous imaging system comprises a signal excitation system, a multi-nuclide multi-frequency signal excitation and acquisition system, a magnetization system and an imaging system. The multi-nuclide multi-frequency signal excitation and acquisition system comprises four nuclide channel modules of 1H, 23Na, 31P and 19F, and each nuclide channel module comprises a signal excitation power amplifier submodule and a signal acquisition submodule. The magnetization system comprises magnets and radio frequency transmitting coils. The imaging system comprises a signal preamplifier, a signal acquisition command module, an image reconstruction module, an image post-processing and display module and an image database.

Description

technical field [0001] The present invention relates to an imaging system, in particular to a multi-nuclide multi-frequency resonance synchronous imaging system for detecting tumor ion dynamic balance, energy metabolism, molecular target changes, and tumor microenvironment changes. Background technique [0002] Malignant tumors seriously endanger human health and are a major problem in the medical field. According to the latest statistical data of the "2015 China Tumor Registration Annual Report", the incidence of malignant tumors in my country has been increasing year by year in the past 10 years. As of 2011, the annual incidence of malignant tumors has reached 3.37 million. "A Cancer Journal for Clinicians" (CA), an authoritative journal of oncology in the world, predicts that this number will reach 4.3 million in 2015, and because the pathogenesis is still unclear and there is a lack of targeted diagnosis in the early stage, the average 5-year survival rate of tumors is o...

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Problems solved by technology

"A Cancer Journal for Clinicians" (CA), an authoritative journal of oncology in the world, predicts that this number will reach 4.3 million in 2015, and because the pathogenesis is still unclear and there is a lack of targeted diagnosis in the early stage, the average 5-year survival rate of tumors is only 36.9%, while lung cancer and other high-incidence malignant tumors, the 5-year survival rate is less than 17%

[0004] Existing MRI imaging equipment is a single-frequency single-nuclide imaging system, which contains relatively simple information, while organisms are complex multi-molecular systems, and there are various forms and degrees of coupling between these multi-molecular nuclides. Therefore, a new imaging system is urgently needed to measure the nuclear magnetic resonance information of multiple nuclides at the same time, so as to provide more direct tumor cell information and precise treatment guidance for biological research and clinical medicine.

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