Method for establishing rat delayed radiation proctitis model

A technology for radiation proctitis and establishing method, which is applied in the field of establishing a model of delayed radiation proctitis in rats

Inactive Publication Date: 2018-01-05
CHINA INST FOR RADIATION PROTECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still no effective clinical treatment for radiation enteritis, and it has become a difficult problem in the medical field

Method used

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  • Method for establishing rat delayed radiation proctitis model
  • Method for establishing rat delayed radiation proctitis model
  • Method for establishing rat delayed radiation proctitis model

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0016] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0017] Such as figure 1 As shown, the establishment method of rat delayed radiation proctitis model provided by the present invention mainly comprises the following steps:

[0018] 1. Observe the changes in the survival rate of rats after different doses of γ-ray irradiation

[0019] SD rats were given different doses of gamma-ray abdominal irradiation, respectively 70.0Gy (10.0Gy / d, continuous 7d) dose group; 56.0Gy (8.0Gy / d, continuous 7d) dose group; 15.0Gy single irradiation. The survival of the rats was observed 2 weeks after the irradiation, and the tolerance dose of the local irradiation of the rats was preliminarily determined.

[0020] 2. Observation of changes in rat rectal pathological tissue and secretion of inflammatory cytokines 15 weeks after different doses of irradiation

[0021] Fifteen weeks after irradiation, the surviving rats ...

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Abstract

The invention belongs to the technical field of radiation medicine, and particularly relates to a method for establishing a rat delayed radiation proctitis model. According to the method, the optimalirradiation dose and the optimal irradiation mode for the successful establishment of the rat radiation proctitis model are screened out, and the rat model for the delayed radiation proctitis is established. The research result shows that 15 weeks after single local irradiation of 15.0Gy gamma rays, the rat rectum mucosa has inflammatory cell infiltration, fiber tissue hyperplasia also appears, and the secretion amount of inflammatory cytokines IL-2 and IL-6 of the rectum tissue is remarkably increased, which indicates the successful establishment of the radiation proctitis model. According tothe technical scheme provided by the invention, by establishing the rat delayed radiation proctitis model, an experimental basis is provided for the intensive study on the treatment means of the delayed radiation proctitis.

Description

technical field [0001] The invention belongs to the technical field of radiation medicine, and in particular relates to a method for establishing a rat delayed radiation proctitis model. Background technique [0002] Radiation enteritis is a common bowel complication caused by radiotherapy for pelvic and abdominal malignant tumors, especially in cervical cancer radiotherapy. Cervical cancer is the second most common tumor occurring in women all over the world after breast cancer. It ranks first among female malignant tumors in developing countries and seriously threatens women's lives. Radiation therapy is a common method of cervical cancer treatment. However, its serious short-term and long-term radioactive adverse reactions seriously limit the clinical efficacy. According to literature reports, the incidence of radiation enteritis is 10%-60%. Once radiation enteritis occurs, it is difficult to treat, especially delayed radiation enteritis often occurs later, sometimes 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D7/00
Inventor 董娟聪蔺素琴张忠新周晋源王婧洁原雅艺刘红艳张睿凤王超左雅慧
Owner CHINA INST FOR RADIATION PROTECTION
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