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A system for predicting the prognosis of patients with liver cancer

A technology for patients and liver cancer, applied in the field of biomedicine, can solve few problems

Active Publication Date: 2020-08-14
BIOMEDICAL ANALYSIS CENT OF ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, tumor research reports a large number of tumor markers, and various liver cancer markers emerge in endlessly, but few of them can be effectively used clinically.

Method used

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  • A system for predicting the prognosis of patients with liver cancer
  • A system for predicting the prognosis of patients with liver cancer
  • A system for predicting the prognosis of patients with liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1. Discovery of liver cancer-related protein signatures, combined molecular marker model, judgment of liver cancer prognosis, P4-HCC prognosis of liver cancer method and validation of its effectiveness

[0058] 1. Discovery of liver cancer-related protein signatures

[0059] 1.1. Cases and samples

[0060] Formalin-fixed and paraffin-embedded human liver tumor tissue and paired paracancerous tissue samples were provided by the Department of Pathology, Southwest Hospital, Chongqing. Providers of liver tumor tissue and matched paracancerous tissue (ie, patients) underwent liver cancer surgery at Chongqing Southwest Hospital from 2005 to 2008. The present invention does not include the following cases: cases with malignant tumors in the past, cases treated with other methods such as liver cancer embolization chemotherapy before operation, and those cases who died within 30 days after operation. Patients who provided liver tumor tissues and matched paracancerous t...

Embodiment 2

[0118] Example 2, P4-HCC prognosis Liver cancer method for further prognosis of BCLC graded liver cancer patients

[0119]The method for the further prognosis of the liver cancer patients of BCLC classification is: for any grade of liver cancer patients (such as patients with 0&A liver cancer) classified by BCLC, obtain the expression score of P4-HCC according to the method of Example 1, and then use the According to the method of step 2.1 of Example 1 for the expression score, the prognosis score is obtained; the method of step 2.2 of Example 1 is used for each prognosis score to determine whether the prognosis of the liver cancer patient is good or poor.

[0120] Using the P4-HCC liver cancer prognosis method, each patient in the liver cancer test group can be further divided into a poor prognosis group or a good prognosis group on the basis of BCLC classification (0&A stage P figure 2 ). The results showed that the P4-HCC liver cancer prognosis method can further predict th...

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Abstract

The invention discloses a system used for predicting prognosis of a liver cancer patient. The system comprises a system for detecting expression quantities of four proteins c-Met, Caspase8, CXCR4 andP-P21, and a protein expression quantity data processing system. The system for detecting the expression quantities of the four proteins measures the expression quantities of the proteins through an immunohistochemistry staining method; and the protein expression quantity data processing system converts the expression quantities of the four proteins in a para-carcinoma tissue of the to-be-predicted liver cancer patient into prognosis score values, and predicts the prognosis of the liver cancer patient according to the prognosis score values.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a system for predicting the prognosis of liver cancer patients. Background technique [0002] Liver cancer is the fifth most common cancer in the world, and the cancer-related mortality rate is second only to lung cancer and gastric cancer, ranking third. According to data released by the World Health Organization in 2011, about 700,000 people die of liver cancer every year in the world. The incidence of liver cancer is on the rise in the world. The incidence of liver cancer in western countries is lower than that in developing countries, but the upward trend is also obvious (the incidence of liver cancer in the United States has doubled in the past 10 years). Therefore, research on liver cancer in western countries in recent years also received great attention. In summary, liver cancer is a major disease that seriously threatens the health and life safety of our people and restricts...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B20/00G16H50/30G16H50/20
CPCG16B20/00
Inventor 夏晴张学敏周涛宫琳
Owner BIOMEDICAL ANALYSIS CENT OF ACADEMY OF MILITARY MEDICAL SCI
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