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Analytical method for quantitative detection of lipid content in blood by terahertz spectroscopy

A quantitative detection, terahertz technology, applied in the field of terahertz spectroscopy, to achieve the effect of convenient diagnosis

Active Publication Date: 2020-05-19
UNIV OF SHANGHAI FOR SCI & TECH
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Problems solved by technology

[0005] The present invention is aimed at the problem that the traditional biochemical analyzer takes too long to test human blood lipids, and proposes an analysis method for the quantitative detection of blood lipid content in blood by terahertz spectroscopy, establishes blood lipid parameter support vectors and corresponding weights, and quickly blood lipid level test

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  • Analytical method for quantitative detection of lipid content in blood by terahertz spectroscopy
  • Analytical method for quantitative detection of lipid content in blood by terahertz spectroscopy
  • Analytical method for quantitative detection of lipid content in blood by terahertz spectroscopy

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Embodiment Construction

[0014] like figure 1 Shown is a flowchart of an analysis method for quantitatively detecting blood lipid content based on terahertz spectroscopy. The specific plan is as follows:

[0015] 1) The blood lipid content substance is made into a sample, and the sample is scanned with a terahertz time-domain spectroscopy system to obtain the time-domain signal of each sample.

[0016] Triglycerides and cholesterol were selected as samples. Then the pure triglyceride and cholesterol particles are mixed with a certain amount of PE powder and compressed into tablets respectively. The THz-TDS system of the Shanghai Modern Optical System Key Laboratory was used to scan the pressed tablet to obtain the time-domain signal of the sample, which was used for the establishment of the characteristic spectrum parameter data in the later stage.

[0017] 2) The blood samples obtained from the hospital are enriched, and the time-domain signals of the blood samples are obtained by scanning with a ...

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Abstract

The invention relates to an analytical method to quantitatively detect lipid content in blood by terahertz spectroscopy. Terahertz spectral absorption coefficient curves of multiple units of actual blood are subjected to one-to-one correspondence with component concentration and component type parameters of lipid identified by hospitals in the current phase a terahertz lipid parameter database isestablished in conjunction with terahertz time-domain spectroscopy of pure triglyceride and cholesterol, parameters of an SVR (support vector regression) model is determined accordingly and is trainedto obtain a support vector and a corresponding weight, and the trained support vector and corresponding weight are used to detect an unknown blood sample. The method of the invention has the advantages that the limit that existing traditional biological chemical analyzer takes a long time to detect blood lipid is broken through, and the problem that existing terahertz wave experiences much influencing signals by water absorption during detecting is also solved; the method has a correct rate of 99% and above to detect the lipid content in blood; the lipid content of blood can be detected conveniently and effectively so that it is convenient for doctors to perform diagnosis and for patients to take treatment.

Description

technical field [0001] The invention relates to a terahertz spectrum application technology, in particular to an analysis method for quantitatively detecting blood lipid content in blood by a terahertz spectrum. Background technique [0002] At present, the commonly used methods for clinical testing of blood lipids in hospitals mainly use biochemical analyzers, and the substances analyzed are mainly cholesterol and triglycerides. Because blood lipid analysis in hospitals needs to add corresponding chemical reagents, there are some deficiencies in blood lipid analysis. First, its analysis cycle is relatively long. For example, the excellent 400 / 450 automatic biochemical analyzer of Shanghai Huashan Hospital has a test speed of 400 tests / hour. The chemical reaction of biochemical instruments only takes a long time, and there are steps such as adding reagents and reagent disposal. In addition, this will increase the cost of long-term detection. [0003] Terahertz is an elec...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/3586G01N21/3577
CPCG01N21/3577G01N21/3586
Inventor 彭滟朱亦鸣汪丽平阳晴柔赵佳宇刘志佳刘扬唐心雨刘可盈郭琳庄松林
Owner UNIV OF SHANGHAI FOR SCI & TECH
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