Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-tumor MDR (multiple drug resistance) interfering drug and preparation method

A multi-drug resistance, anti-tumor technology, applied in the field of anti-tumor drugs, can solve the problems of high cost and difficult synthesis of reversal agents

Inactive Publication Date: 2018-03-23
XIHUA UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an anti-tumor multi-drug resistance interfering drug and a preparation method, which solves the technical problems of difficulty in synthesis of reversal agents used in the prior art and high cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-tumor MDR (multiple drug resistance) interfering drug and preparation method
  • Anti-tumor MDR (multiple drug resistance) interfering drug and preparation method
  • Anti-tumor MDR (multiple drug resistance) interfering drug and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0019] An embodiment of the present invention provides an anti-tumor multi-drug resistance interfering drug, comprising: 1-3 parts of echinocytic acid or its derivatives, and 1-2 parts of oleanolic acid.

[0020] Wherein, the structural characteristics of echinocytic acid or its derivatives are:

[0021]

[0022] Among them, the compound and the number are specifically: echinocytic acid, R1 is -OH, R2 is -COOH; compound 2 (TRSZ-2), R1 is =O, R2 is -COOH; compound 3 (TRSZ-3), R1 is =NOH, R2 is -COOH; Compound 4 (TRSZ-4), R1 is -OH, R2 is -COOCH3; Compound 5 (TRSZ-5), R1 is =O, R2 is -COOCH3; Compound 6 (TRSZ-6 ), R1 is =NOH, R2 is-COOCH3.

[0023] A preferred embodiment of the present invention is anti-tumor multi-drug resista...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of anti-tumor drugs and discloses an anti-tumor MDR (multiple drug resistance) interfering drug and a preparation method. The interfering drug is prepared from 1-3 parts of echinocystic acid or echinocystic acid derivatives and 1-2 parts of oleanolic acid. Echinocystic acid and the echinocystic acid derivatives are effectively utilized to inhibit P-gp (P-glycoprotein) activity of a drug-resistant strain, so that chemotherapeutic drugs pumped out of cells are reduced, effects of the chemotherapeutic drugs are enhanced, and the sensitization effect is realized.Besides, by the aid of oleanolic acid, hepatotoxicity is remarkably reduced, and therefore, the interfering drug is safer and more effective in chemotherapy.

Description

technical field [0001] The invention relates to the field of anti-tumor drugs, in particular to an anti-tumor multi-drug resistance interfering drug and a preparation method. Background technique [0002] At present, chemotherapy is still one of the main clinical treatments for malignant tumors, and the multidrug resistance (MDR) of tumor cells is an important reason for the failure of chemotherapy. MDR refers to the cross-resistance of tumor cells to other anti-tumor drugs with different structures and mechanisms of action while developing resistance to one anti-tumor drug. The main cause of MDR is the efflux of antitumor drugs by P-glycoprotein (P-gp), and other reasons include multidrug resistance-related protein (MRP), lung resistance protein (LRP), Glutathione and glutathione-S-transferase, PKC and TopoII, etc. [0003] P-gp is the expression product of MDR1 gene, which is a member of ABC (ATP-bindingcassette) family and contains two transmembrane domains and two ATP-...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P35/00
CPCA61K31/56A61K2300/00
Inventor 赖朋曹旭
Owner XIHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com