Drug compositions and applications that treat and prevent intestinal mucosal injury

A technology for intestinal mucosal damage and composition, applied in the field of traditional Chinese medicine and natural medicine, can solve the problems of high mortality rate, limited efficacy of antibiotics, increasing prevalence rate, etc. The effect of relieving blood in the stool

Active Publication Date: 2021-02-12
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Desperately, in the treatment of related infections, the efficacy of antibiotics is very limited, the mortality rate remains high, and the prevalence of drug-resistant bacterial infections caused by the overuse of antibiotics has shown an alarming increase, and has caused Various adverse reactions, there has been no effective drug to control the development of the disease clinically

Method used

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  • Drug compositions and applications that treat and prevent intestinal mucosal injury
  • Drug compositions and applications that treat and prevent intestinal mucosal injury
  • Drug compositions and applications that treat and prevent intestinal mucosal injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of cicadae artificial culture product

[0030] ①Preparation of PDA solid slant: The proportion of PDA medium is per 1000mL medium: 200g of potatoes, 20g of glucose, 20g of agar, put the peeled and diced potatoes in a container, add 1000mL of water, boil for 20min, filter, add glucose and agar (liquid culture Add water to 1000mL, heat to dissolve, then divide into test tubes, the filling volume is 1 / 4 of the test tube length, plug with cotton plugs, and sterilize in a sterilizing pot under 0.1MPa pressure for 30min , Place the test tubes on a slant plate while they are hot to cool.

[0031] ②Preparation of slant seed: Take the freeze-dried patented preserved strain, activate it in PDA liquid medium by aseptic operation, transfer the tube, and cultivate it at 22°C for 3 days, and select a good growing strain for use;

[0032] ③PDA Erlenmeyer flask seed solution preparation: Per 1000mL of culture solution: 200g of potatoes and 20g of glucose,...

Embodiment 2

[0037] Embodiment 2: the preparation of cicadae artificial culture product

[0038] ①Preparation of PDA solid slant: The proportion of PDA medium is per 1000mL medium: 200g of potatoes, 20g of glucose, 20g of agar, put the peeled and diced potatoes in a container, add 1000mL of water, boil for 20min, filter, add glucose and agar (liquid culture Add water to 1000mL, heat to dissolve, then divide into test tubes, the filling volume is 1 / 4 of the test tube length, plug with cotton plugs, and sterilize in a sterilizing pot under 0.1MPa pressure for 30min , Place the test tubes on a slant plate while they are hot to cool.

[0039] ②Preparation of slant seed: Take the freeze-dried patented preserved strain, activate it in PDA liquid medium by aseptic operation, transfer the tube, and cultivate it at 22°C for 3 days, and select a good growing strain for use;

[0040] ③PDA Erlenmeyer flask seed solution preparation: Per 1000mL of culture solution: 200g of potatoes and 20g of glucose,...

Embodiment 3

[0050] Embodiment 3: the preparation of cicadae artificial culture product

[0051] ①Preparation of PDA solid slant: The proportion of PDA medium is per 1000mL medium: 200g of potatoes, 10g of glucose, 20g of agar, put the peeled and diced potatoes in a container, add 1000mL of water, boil for 50min, filter, add glucose and agar, and make up water to 1000mL, heated to dissolve, and then dispensed into test tubes, the filling volume is 1 / 4 of the length of the test tube, plugged with a cotton plug, placed in a sterilizer for 30min under a pressure of 0.15MPa, and put the test tube on an inclined Cool on the panel.

[0052] ②Preparation of slant seed: take the freeze-dried patented preserved strain, activate it in PDA liquid medium by aseptic operation, transfer the tube, culture it at 22°C for 5 days, and select a good growing strain for use;

[0053] ③PDA Erlenmeyer flask seed solution preparation: per 1000mL culture solution: 200g of potatoes, 20g of glucose, put the peeled ...

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PUM

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Abstract

The present invention provides a pharmaceutical composition and application for treating and / or preventing intestinal mucosal damage. The active ingredient of the pharmaceutical composition comprises an artificially cultured product of Cicada, and the artificially cultured product of Cicada is Isaria cicadae) Y.R.L-3 CGMCC No 13684 is inoculated into a culture obtained by growing after a solid cultivation medium, and / or an extract of the culture. The invention can obviously repair intestinal mucosal damage, simultaneously relieve symptoms such as blood in the stool and diarrhea, has no toxic and side effects on the liver and kidney, and has obvious therapeutic and preventive effects on various types of intestinal mucosal damage.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and natural medicine, and relates to a single traditional Chinese medicine for treating various intestinal mucosal injuries, especially inflammatory bowel disease, its composition and application. Background technique [0002] The main factors causing intestinal mucosal damage are severe trauma, severe infection, burns, shock, acute pancreatitis and other critically ill patients may have damage to the intestinal mucosal barrier, and the latter can aggravate the conditions of various primary diseases. Promote, reciprocal cause and effect. Among them, chemotherapy drugs, abdominal dialysis, bacterial peritonitis, inflammatory bowel disease and other diseases are the most common damage to the intestinal mucosa, and intestinal mucosal barrier damage will cause bacterial translocation, so that pathogenic bacteria parasitic in the large intestine can be translocated to the small int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/068A61P1/00C12N1/14C12R1/645A61K35/64
CPCA61K36/068A61K35/63C12N1/14
Inventor 于瑞莲周玉磊陆宸卫梦婷郭瑞康
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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