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Method for improving biodegradability and osteochondral tissue repair performance

A tissue repair and biodegradation technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of osteochondral damage, high hardness and difficult to shape cartilage, etc.

Inactive Publication Date: 2019-04-30
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently clinically used collagen-bonded calcium phosphate (abbreviated as collagen / calcium phosphate) bone repair scaffold has a good effect on the repair of dense bone, but it is not suitable for repairing cartilage, including osteochondral damage, due to its high hardness and difficulty in shaping.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example

[0013] Weigh 15g of collagen powder, add 1000ml of pure water for injection to dissolve and make a 1.5% solution, and adjust the pH value to 3.8 with acetic acid. Divide into quarters by volume. Vacuum pumping rate removes air bubbles. In the first part, add HA with a particle size of 0.3mm HA reaches 75% of the collagen / HA weight ratio. The stirrer was stirred at a low speed of 500 rpm until a uniform HA suspension was formed, and the stirring was continued for several hours to make it swell into a colloid. Gently pour the collagen / HA colloid containing particle size > 0.3mm HA into a container, gently pour the collagen / HA colloid containing particle size 0.1-0.3mm HA on it, followed by the HA containing particle size < 0.1mm Collagen / HA colloid, and collagen solution without HA. Quickly place the container at -20°C to freeze solid. Vacuum freeze-drying obtains a semi-solid collagen sponge scaffold, apparently with high hardness at one end and high elasticity at the other...

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Abstract

The invention provides a method for improving biodegradability and osteochondral tissue repair performance, belongs to the field of biomedical materials, mainly solves the problem that repairing of acartilage tissue and fusing of a to-be-repaired cartilage tissue with a connected bone dense part (namely hard bone part) cannot be carried out at the same time when the osteochondral injury is treated at present, and overcomes the phenomenon that a collagen / calcium phosphate bone repair material cannot repair osteochondral tissue injury well.

Description

technical field [0001] The invention relates to a method for improving the biodegradation performance and the repair performance of osteochondral tissue, and the prepared collagen sponge support can be used for repairing the damage of osteochondral tissue. Background technique [0002] Disease or trauma can cause damage to the cartilage layer of human bones (also known as osteochondral), which can be used clinically to repair or regenerate damaged cartilage tissue by implanting cartilage-like substitutes, especially with biocompatibility and biodegradability Sexual collagen. Collagen as a scaffold can induce the cells that promote the growth of blood vessels and nerve tissue to attach, migrate and grow at the site of cartilage injury, thereby promoting the regeneration of cartilage tissue. Calcium phosphate is the main inorganic phase chemical component of bone tissue, especially hydroxyapatite (chemical formula Ca 5 (PO 4 ) 3 OH, English hydroxyapatite, abbreviated as H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/12A61L27/50A61L27/56
CPCA61L27/24A61L27/12A61L27/50A61L27/56A61L2430/06
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