Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for improving osteochondral tissue performance and biological traits

A technology of tissue performance and biological characteristics, applied in medical science, prosthesis, etc., can solve the problems of osteochondral damage, high hardness and difficult to shape cartilage, etc.

Inactive Publication Date: 2019-05-24
南杰
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently clinically used collagen-bonded calcium phosphate (abbreviated as collagen / calcium phosphate) bone repair scaffold has a good effect on the repair of dense bone, but it is not suitable for repairing cartilage, including osteochondral damage, due to its high hardness and difficulty in shaping.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example

[0013] Weigh 15g of collagen powder, add 1000ml of pure water for injection to dissolve and make a 1.5% solution, and adjust the pH value to 3.8 with acetic acid. Divide into quarters by volume. Vacuum pumping rate removes air bubbles. In the first part, HA with a particle size of 0.3 mm accounts for 75% of the weight ratio of collagen / HA. The stirrer was stirred at a low speed of 500 rpm until a uniform HA suspension was formed, and the stirring was continued for several hours to make it swell into a colloid. Gently pour the collagen / HA colloid containing HA with a particle size > 0.3mm into a container, and gently pour the collagen / HA colloid with a particle size of 0.1-0.3mm HA on it, followed by the ones with a particle size < 0.1mm HA collagen / HA colloid, and HA-free collagen solution. Quickly place the container at -20°C to freeze solid. Vacuum freeze-drying obtains a semi-solid collagen sponge scaffold, apparently with high hardness at one end and high elasticity at...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention describes a method for improving osteochondral tissue performance and biological traits, and belongs to the field of biomedical materials, mainly solving the problems that osteochondraltissues cannot be repaired during treatment of osteochondral injuries and the to-be-repaired osteochondral tissues are fused with dense bone parts (namely hard bone parts) connected therewith in the prior art. The defect that current clinical collagen / calcium phosphate bone repairing materials cannot well repair injuries of the osteochondral tissues is overcome.

Description

technical field [0001] The invention relates to a method for improving and repairing bone cartilage tissue performance and biological characteristics, and belongs to the field of biomedical materials. Background technique [0002] Disease or trauma can cause damage to the cartilage layer of human bones (also known as osteochondral), which can be used clinically to repair or regenerate damaged cartilage tissue by implanting cartilage-like substitutes, especially with biocompatibility and biodegradability Sexual collagen. Collagen as a scaffold can induce the cells that promote the growth of blood vessels and nerve tissue to attach, migrate and grow at the site of cartilage injury, thereby promoting the regeneration of cartilage tissue. Calcium phosphate is the main inorganic phase chemical component of bone tissue, especially hydroxyapatite (chemical formula Ca 5 (PO 4 ) 3 OH, English hydroxyapatite, abbreviated as HA) and β-tricalcium phosphate (chemical formula Ca 3 (P...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/40A61L27/24A61L27/12A61L27/56
Inventor 南杰
Owner 南杰
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com