Long-term-preserved immune cell gel preparation and preparation method thereof
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A technology of immune cells and gel preparations, applied in the field of gel preparations, to achieve the effects of improving dispersibility, strong practicability, and increasing drug release speed
Active Publication Date: 2018-04-20
北京唐颐惠康生物医学技术有限公司
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Problems solved by technology
[0004] In order to solve the above-mentioned problems existing in the existing gel preparations, the present invention provides a long-term storage immune cell gel preparation that has good stability, fast drug release, and is not prone to dehydration and mildew.
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Embodiment 1
[0045] An immune cell gel preparation that can be stored for a long time, the gel preparation is composed of immune cells and a gel matrix, and each g of the gel matrix contains 0.3×10 11 immune cells, the gel matrix is mainly composed of the following components by weight:
[0046]
[0047] Among them, the immune cells are T lymphocytes.
Embodiment 2
[0049] An immune cell gel preparation that can be preserved for a long time, the gel preparation is composed of immune cells and a gel matrix, and each g of the gel matrix contains 0.8×10 11 immune cells, the gel matrix is mainly composed of the following components by weight:
[0050]
[0051] Among them, the immune cells are B lymphocytes.
[0052] The preparation method of this gel preparation comprises the following steps:
[0053] S1: preparing mistletoe leaf extract;
[0054] S2. Dissolve mistletoe leaf extract in deionized water, let it stand overnight, add propylene glycol alginate, oleyl alcohol and guaiac, stir for 10 minutes at a speed of 3500 rpm, add dextran, stir for 13 minutes, and rotate at a speed of 500 rpm min, configure the gel matrix, add 0.8×10 11 immune cells, and stir evenly.
[0055] In step S1, the preparation method of the mistletoe leaf extract is as follows:
[0056] S1: washing mistletoe leaves, freeze-drying, and grinding the dried mist...
Embodiment 3
[0061] An immune cell gel preparation that can be preserved for a long time, the gel preparation is composed of immune cells and a gel matrix, and each g of the gel matrix contains 1.2×10 11 immune cells, the gel matrix is mainly composed of the following components by weight:
[0062]
[0063] Among them, the immune cells are K lymphocytes.
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Abstract
The invention provides a long-term-preserved immune cell gel preparation and a preparation method thereof. The gel preparation contains immune cells and a gel matrix, wherein the gel matrix mainly contains the following components: deionized water, dextran, a mistletoe leaf extract, propylene glycol alginate, oleyl alcohol and guaiacum. The method comprises the following steps: preparing the mistletoe leaf extract; and dissolving the mistletoe leaf extract into deionized water, standing for one night, adding propylene glycol alginate, oleyl alcohol and guaiacum, stirring, adding dextran, stirring, preparing the gel matrix, adding the immune cells into the gel matrix, and uniformly stirring. According to the preparation method, the cell activity of the immune cells in a long-term preservation process can be guaranteed, meanwhile, the stability of the immune cell gel preparation can be improved, the pesticide effect of the long-term-preserved immune cell gel preparation can be guaranteed, the drug release efficiency can be improved, and the mildewing can be prevented; and the immune cell gel preparation is strong in practicability.
Description
technical field [0001] The invention belongs to the technical field of gel preparations, in particular to a long-term preservation immune cell gel preparation and a preparation method. Background technique [0002] At present, the diagnosis and treatment of diseases has entered the era of molecules and cells. Stem cells and immune cells have great therapeutic potential. Immune cells refer to cells that participate in or are related to immune responses. Immune cells generally include lymphocytes, dendritic cells, monocytes / macrophages, granulocytes, mast cells, etc. Immune cells can be divided into many types, and various immune cells play important roles in the human body. At this stage, the application of immune cells is relatively limited, and no immune cell preparations have been seen at home and abroad. [0003] Gel preparation is a new drug dosage form that has emerged in China in recent years. Gel preparation refers to a thick liquid or semi-solid preparation in the ...
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