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A kind of oral solid self-emulsifying dispersion for treating livestock and poultry respiratory diseases

A solid dispersant and self-emulsifying technology, which is applied in the direction of respiratory diseases, climate change adaptation, medical preparations of non-active ingredients, etc., can solve the problems of drug-resistant strains, drug residues, and poor therapeutic effect, and achieve improvement Effects of drug efficacy, improvement of stability, and extension of storage time

Active Publication Date: 2021-01-26
XINYANG AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide an oral solid self-emulsifying dispersion for the treatment of livestock and poultry respiratory diseases, which can effectively solve the problems of poor therapeutic effect and easy to produce drug-resistant strains and drug residues

Method used

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  • A kind of oral solid self-emulsifying dispersion for treating livestock and poultry respiratory diseases
  • A kind of oral solid self-emulsifying dispersion for treating livestock and poultry respiratory diseases
  • A kind of oral solid self-emulsifying dispersion for treating livestock and poultry respiratory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 preparation volatile oil

[0022] 1. Mix forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil in a ratio of 2:5:1:1:1 by weight to prepare 1# volatile oil;

[0023] 2. Mix forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil in a ratio of 4:3:2:2:1 by weight to prepare 2# volatile oil;

[0024] 3. Mix forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil in a ratio of 5:2:3:3:0.5 by weight to prepare 3# volatile oil.

Embodiment 2

[0025] Example 2 Preparation of oral solid self-emulsifying dispersion for the treatment of livestock and poultry respiratory diseases

[0026] The first step is to accurately weigh 60g of 1# volatile oil, 30g of emulsifier, 10g of co-emulsifier, and 200g of solid dispersant carrier according to parts by weight; first, add emulsifier and co-emulsifier to 1# volatile oil. Stir to mix;

[0027] In the second step, after melting the solid dispersant carrier in a water bath at 80°C, slowly add the material stirred and mixed in the first step while continuously stirring, and form a volatile oil self-emulsifying mixture after mixing evenly;

[0028] In the third step, pour the volatile oil self-emulsifying mixture obtained in the second step onto a glass plate pre-cooled to 4°C to cool and solidify, then freeze at -18°C for 2 hours, and finally crush it through an 80-mesh sieve to obtain 1# Oral solid self-emulsifying dispersion product containing volatile oil.

[0029] By the sam...

Embodiment 3

[0032] Example 3 Quality Evaluation of Oral Solid Self-emulsifying Dispersion Finished Products Prepared by the Present Invention

[0033] 1. Shape

[0034] The finished products of 1#, 2#, 3# oral solid self-emulsifying dispersion prepared by the present invention are white or light yellow powder with the smell of essential oil.

[0035] 2. Self-emulsification rate

[0036] The rate of self-emulsification is an important parameter for evaluating solid self-emulsifying dispersions. The self-emulsification rates of 1#, 2#, and 3# oral solid self-emulsifying dispersions containing volatile oil in water and PBS with pH 7.4 were inspected by visual inspection, and the results are shown in Table 1 below.

[0037] Table 1

[0038]

[0039] Conclusion: From the results in Table 1 above, it can be seen that the self-emulsification rate of the oral solid self-emulsifying dispersion prepared by the present invention is relatively fast, and meets the quality standards for solid sel...

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Abstract

The invention discloses an oral solid self-emulsifying dispersion for treating respiratory diseases of livestock and poultry, which consists of 4-7 parts of volatile oil of the following raw materials, 2-5 parts of emulsifier, 1-3 parts of co-emulsifier, and 10 parts of solid dispersant carrier Prepared in ‑50 parts; its volatile oil is mixed with forsythia oil, eucalyptus oil, almond oil, bellflower oil, and perilla oil; the solid dispersion carrier is polyethylene glycol. The present invention uses pharmaceutical grade forsythia oil, eucalyptus oil, almond oil, bellflower oil and perilla oil to formulate volatile oil in a certain proportion, fully utilizes the active ingredients of traditional Chinese medicine, and combines emulsifier, co-emulsifier and solid dispersant Combined with the carrier, the finished oral solid self-emulsifying dispersion prepared is pure natural and has no toxic and side effects. When used for the prevention and control of livestock and poultry respiratory diseases, it can exert the stability of the volatile oil, improve the efficacy of the volatile oil, and is not easy to produce drug resistance. There is almost no residue in the body of livestock and poultry, which reduces the damage to the human body and the environment; meanwhile, the production process of the invention is simple and convenient for large-scale production.

Description

technical field [0001] The invention relates to traditional Chinese veterinary medicine technology, in particular to an oral solid self-emulsifying dispersion for treating respiratory diseases of livestock and poultry. Background technique [0002] Livestock and poultry respiratory diseases are syndromes caused by a variety of pathogens. They have the characteristics of rapid onset, rapid spread, long course of disease, high mortality, and difficult control. The clinical manifestations are panting, coughing, abdominal breathing and other respiratory symptoms. Respiratory diseases of livestock and poultry are the main diseases affecting the development of my country's aquaculture industry at present, often causing huge economic losses to the aquaculture industry. According to literature reports, the incidence of respiratory diseases in large-scale pig farms is generally between 30% and 60%, and the mortality rate is 5% to 30%. The incidence of respiratory diseases in chicken ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/14A61K47/10A61P11/00
CPCA61K9/146A61K36/346A61K36/535A61K36/61A61K36/634A61K36/736A61K2300/00Y02A40/70
Inventor 叶兆伟赵存真张宇航吴海港张欢欢
Owner XINYANG AGRI & FORESTRY UNIV
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