Preparation method of duck 2 type adenovirus inactivated vaccine

A technology for inactivated vaccines and adenoviruses, applied in microorganism-based methods, biochemical equipment and methods, antiviral agents, etc., can solve problems such as lack of such vaccines, and achieve immunogenicity, safety, and protection. high rate effect

Inactive Publication Date: 2018-05-04
TIANJIN RINGPU BIO TECH
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] The present invention aims at the technical defect of prior art, provides a kind of preparation method of duck type 2 adenovirus inactivated vaccine, to solve the technical problem of lacking this kind of vaccine in prior art

Method used

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  • Preparation method of duck 2 type adenovirus inactivated vaccine
  • Preparation method of duck 2 type adenovirus inactivated vaccine

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Embodiment Construction

[0020] Specific embodiments of the present invention will be described in detail below. In order to avoid unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0021] The language of approximation used in the following examples can be used for quantitative expressions, showing that some variation in quantity is permissible without changing the basic function. Therefore, the numerical value corrected by language such as "approximately", "about", etc. is not limited to the exact numerical value itself. In some embodiments, "about" means that the numerical value of the correction is allowed to vary within plus or minus ten percent (10%), eg, "about 100" means any number between 90 and 110. Furthermore, in the expression "about the first numerical value to the second numerical value", both numerical values ​​of the first and second numerical values ​​are modified approximately at the same time. In some cases, the ...

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Abstract

The invention provides a preparation method of a duck type 2 adenovirus inactivated vaccine. According to the technical scheme, duck adenovirus is proliferated by utilizing chicken liver cancer cells;after the duck adenovirus is inactivated, gamma-interferon is added; an imported white oil adjuvant is utilized to prepare the safe and effective duck type 2 adenovirus inactivated vaccine. The ducktype 2 adenovirus inactivated vaccine prepared by the preparation method has good safety, can be used for stimulating organisms to generate antibodies earlier and has a high protection rate. The vaccine provided by the invention can be used for effectively ensuring immunogenicity; the defect that the vaccine is lacked in the prior art is overcome; meanwhile, the duck type 2 adenovirus inactivatedvaccine can have an exact effect on prevention of the duck type 2 adenovirus.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, further relates to the preparation technology of vaccines, and in particular relates to a preparation method of a duck type 2 adenovirus inactivated vaccine. Background technique [0002] Avian adenoviruses are divided into subgroups I, II, and III. At present, domestic and foreign experts and scholars mainly conduct research on subgroups I and III. Duck adenovirus type 2 belongs to the tentative species of subgroup I. It was first isolated from Muscovy ducks by J.F.Bouquet of Hungary in 1977. It is not related to the known viruses of chickens and turkeys, but can be found in chickens and ducks. grow in cells. In recent years, domestic researchers have isolated the virus from Guangdong, Fujian, etc. using viral metagenomics, and considered the virus to be a new duck-derived virus. The disease mainly occurs in 20-30-day-old ducks. The diseased ducks manifest as lethargy, d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/235A61K39/39A61P31/14C12N7/00C12R1/93
Inventor 张立霞李亚杰康亚男郁宏伟杨保收唐荣宏陈冰郑文卿
Owner TIANJIN RINGPU BIO TECH
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