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Application of catechin used for lowering liver damage caused by dimethylformamide

A technology of dimethylformamide and catechin, applied in the field of medicine, can solve problems such as lack of treatment methods

Inactive Publication Date: 2018-05-08
华茗国际健康产业(香港)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides the application of catechin for alleviating the liver injury caused by dimethylformamide, so as to solve the technical problem of lacking a treatment method for such toxic liver injury in the prior art

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  • Application of catechin used for lowering liver damage caused by dimethylformamide
  • Application of catechin used for lowering liver damage caused by dimethylformamide
  • Application of catechin used for lowering liver damage caused by dimethylformamide

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Embodiment Construction

[0026] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0027] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

The invention provides application of catechin used for lowering liver damage caused by dimethylformamide. According to the technical scheme, firstly, the metabolic pathway along with DMF invades intothe human body in a contact mode is studied, and according to the product type and damage conditions of the liver metabolic process, the feasibility of treating toxicity damage by catechin is inspected. On this basis, through an animal experiment, a DMF poisoning model is built, and with the DMF poisoning model being an experiment object, the treatment effect of catechin on poisoned animals is inspected. An experiment result shows that by orally taking catechin, the antioxidiant enzyme activity in the liver tissue can be obviously improved, and meanwhile, the phenomenon that the contents of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase and the like are too high is also avoided. Besides, it is found that catechin has a definite lowering effect on inflammatory damage caused by DMF, and it is further found that the pharmacologic action of catechin is achieved by lowering the expression quantity of proinflammatory cytokine IL-1beta and IL-6.

Description

technical field [0001] The invention relates to the technical field of medicine, and further relates to the new medical application of the substance, in particular to the application of catechin for alleviating liver damage caused by dimethylformamide. Background technique [0002] Dimethylformamide (DMF) is a transparent liquid that is miscible with water and most organic solvents. It is a common solvent for chemical reactions. Dimethylformamide is unstable in the presence of a strong base such as sodium hydroxide or a strong acid such as hydrochloric or sulfuric acid and hydrolyzes to formic acid and dimethylamine. In industrial applications, dimethylformamide is mainly used as a solvent for extracting acetylene and making polyacrylonitrile fibers, and is also used in industries such as organic synthesis, dyestuffs, pharmaceuticals, petroleum refining and resins. Poisoning can be caused by exposure to DMF vapor in the above jobs. Most of the causes of acute poisoning ar...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P1/16
CPCA61K31/353
Inventor 郭晓瑞
Owner 华茗国际健康产业(香港)有限公司
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