Applications of roxadustat in preparation of pharmaceutical preparation for assisted treatment of diabetic foot

Abstract

The invention discloses new medical uses of roxadustat, specifically applications in preparation of a pharmaceutical preparation for assisted treatment of diabetic foot. According to the present invention, the uses of roxadustat in the diabetic foot treating pharmaceutical preparation are firstly disclosed; and the clinical test research results show that the foot ulcers of diabetic foot patientscan be significantly treated, hyperlipidemia, hypertension, inflammation and other systemic symptoms can be improved, the recurrence rate can be reduced, and the life quality of patients is exactly improved after the diabetic foot patients are treated with roxadustat.

Description

Technical field [0001] The present invention relates to a new use of Kobime, in particular to the application in the preparation of pharmaceutical preparations for auxiliary treatment of diabetic feet. Background technique [0002] Diabetic foot is one of the common chronic complications of diabetes, and it is also the main cause of amputation and disability in diabetic patients. Diabetic vascular disease and neuropathy are the basic causes of diabetic foot complications. Diabetic feet are particularly prone to vascular and neuropathy. The mutual influence of diabetic vascular and neuropathy will cause a series of clinical foot diseases, including toe disease. Callus formation, skin damage and foot ulcers, and foot deformities caused by musculoskeletal disorders. In China, the incidence of diabetes is 11.6%, and among them, approximately 12%-25% of diabetic patients will suffer from diabetic foot disease. As the life expectancy of the population increases, the disease has becom...

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Problems solved by technology

[0006] Kebomei, as a new type of oral hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs), has a good effect in the treatment of anemia patients with kidney disease, the drug can stimulate the body to produce a similar The effect in the high altitude area prompts the body to produce more red blood cells to transport the oxygen needed by the body, so it can be used to improve the reduction of red blood cells (carrying oxygen in the body) in the blood accompanied by anemia in patients with end-stage renal disease and chronic kidney disease , and the symptoms of reduced hemoglobin (the protein needed for red blood cells to carry oxygen), but its application in the preparation of pharmaceutical preparations for the treatment of diabetic foot has not yet been reported

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