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Applications of roxadustat in preparation of pharmaceutical preparation for assisted treatment of diabetic foot

A technology for diabetic foot and pharmaceutical preparations, applied in drug combinations, metabolic diseases, skin diseases, etc., can solve unreported problems, achieve the effects of improving quality of life, improving therapeutic effect, and reducing recurrence rate

Inactive Publication Date: 2018-05-08
JIANGSU WANBANG BIOPHARMLS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Kebomei, as a new type of oral hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs), has a good effect in the treatment of anemia patients with kidney disease, the drug can stimulate the body to produce a similar The effect in the high altitude area prompts the body to produce more red blood cells to transport the oxygen needed by the body, so it can be used to improve the reduction of red blood cells (carrying oxygen in the body) in the blood accompanied by anemia in patients with end-stage renal disease and chronic kidney disease , and the symptoms of reduced hemoglobin (the protein needed for red blood cells to carry oxygen), but its application in the preparation of pharmaceutical preparations for the treatment of diabetic foot has not yet been reported

Method used

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  • Applications of roxadustat in preparation of pharmaceutical preparation for assisted treatment of diabetic foot
  • Applications of roxadustat in preparation of pharmaceutical preparation for assisted treatment of diabetic foot
  • Applications of roxadustat in preparation of pharmaceutical preparation for assisted treatment of diabetic foot

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Experimental program
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Effect test

Embodiment 1

[0023] 1.1 Subjects and groups

[0024] 50 cases of diabetic foot patients (diagnostic criteria refer to the "Diabetic Foot International Clinical Guidelines". The grading standard refers to Wagner grading standards: grade 0 is a high risk of foot ulcers, but ulcers have not yet formed; grade I is superficial Ulcer, but no clinical signs of infection, but corpus calluses may appear; Grade Ⅱ is a deep foot ulcer, may be accompanied by cellulitis, but no deep abscess or osteomyelitis; Grade Ⅲ is deep infection, osteomyelitis And abscess; grade IV is localized gangrene; grade V is gangrene involving the entire foot. The enrolled patients are 41 males and 9 females. According to Wagner classification, there are 8 patients at grade 0 and 32 patients at grade I to IV. , Grade V is 10. There are 25 patients with diabetic retinopathy, 15 patients with diabetic nephropathy, 31 patients with hypertension, 29 patients with hyperlipidemia, and 41 patients with infection. Randomly divided int...

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PUM

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Abstract

The invention discloses new medical uses of roxadustat, specifically applications in preparation of a pharmaceutical preparation for assisted treatment of diabetic foot. According to the present invention, the uses of roxadustat in the diabetic foot treating pharmaceutical preparation are firstly disclosed; and the clinical test research results show that the foot ulcers of diabetic foot patientscan be significantly treated, hyperlipidemia, hypertension, inflammation and other systemic symptoms can be improved, the recurrence rate can be reduced, and the life quality of patients is exactly improved after the diabetic foot patients are treated with roxadustat.

Description

Technical field [0001] The present invention relates to a new use of Kobime, in particular to the application in the preparation of pharmaceutical preparations for auxiliary treatment of diabetic feet. Background technique [0002] Diabetic foot is one of the common chronic complications of diabetes, and it is also the main cause of amputation and disability in diabetic patients. Diabetic vascular disease and neuropathy are the basic causes of diabetic foot complications. Diabetic feet are particularly prone to vascular and neuropathy. The mutual influence of diabetic vascular and neuropathy will cause a series of clinical foot diseases, including toe disease. Callus formation, skin damage and foot ulcers, and foot deformities caused by musculoskeletal disorders. In China, the incidence of diabetes is 11.6%, and among them, approximately 12%-25% of diabetic patients will suffer from diabetic foot disease. As the life expectancy of the population increases, the disease has becom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/472A61P3/10A61P17/02A61K31/155A61K31/4545A61K31/64A61K31/519
CPCA61K31/155A61K31/4545A61K31/472A61K31/519A61K31/64
Inventor 王伟李惠珠乔德水
Owner JIANGSU WANBANG BIOPHARMLS
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