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Pharmaceutical composition for preventing and treating depression and preparation method thereof

A composition and technology for depression, which is applied in the field of medicine, can solve problems such as easy recurrence of the disease, failure to fundamentally control the development of depression, and unconsolidated curative effect, and achieve broad clinical application prospects, increase the intake of sugar water, and achieve the effect of reasonable formula

Inactive Publication Date: 2018-05-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The basic theory of traditional Chinese medicine believes that "stagnation of liver qi" is the basic pathogenesis of depression, so the treatment generally focuses on "soothing the liver and regulating qi", such as Xiaoyao powder, Baishao Jieyu granules, etc.; Depression drugs still have the problem of not consolidating the curative effect and easy recurrence of the disease, and cannot fundamentally control the occurrence and development of depression

Method used

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  • Pharmaceutical composition for preventing and treating depression and preparation method thereof
  • Pharmaceutical composition for preventing and treating depression and preparation method thereof
  • Pharmaceutical composition for preventing and treating depression and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of the pharmaceutical composition of the present invention

[0023] Weigh 9g of Coptis chinensis, 3g of cinnamon, 15g of Morinda officinalis and 15g of Epimedium, add water to soak for half an hour, decoct 2 times for 30 minutes each time, mix the decoction obtained twice to obtain the soup of the present invention Agent.

[0024] Method of administration: Take 600ml of the above-mentioned decoction, take 200ml each time, three times a day, take it warmly 1-2 hours after meals.

[0025] In the following, the beneficial effects of the present invention are proved through pharmacodynamic experiments.

experiment example 1

[0026] Experimental Example 1 The effect of the pharmaceutical composition of the present invention on the behavior and brain monoamine transmitters in depression model rats

[0027] 1Materials and methods

[0028] 1.1 Experimental materials

[0029] 1.1.1 Experimental animals: 84 female SD rats (SPF grade) were farmed by the Sichuan Provincial Experimental Animal Committee (animal certificate number: SCXK[川]2008-14), weighing 180~220g, according to weight and Open-Field method scores were similar and randomly divided into blank group, depression model group, low, medium and high dose of Wenshen Jieyou Fang depression group, Xiaoyaosan high dose group and fluoxetine group. Rats in each group grew under the same conditions with free drinking and food.

[0030] 1.1.2 Experimental instrument and reagent open box (homemade): made of opaque material, column body, height 40cm, length and width 80cm each, the bottom surface of the peripheral wall is black, and the bottom surface is composed...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating depression. The pharmaceutical composition comprises the following raw materials in parts by weight: 2.4-3.6 parts of coptis, 0.8-1.2 parts of cinnamon, 4-6 parts of Morinda officinalis, and 4-6 parts of epimeddium. According to an assistant and guide theoretical reasonable formula of traditional Chinese medicine, a drug effect experiment proves that the pharmaceutical composition can obviously improve a mice Open-Field score, increases syrup intake amount and levels of 5-hydroxytryptamine (5-HT), dopamine (DA), and norepinephrine (NE), the efficacy of the pharmaceutical composition is equal to that of commonly used drugs such as Xiaoyao powder and fluoxetine for depression, and the pharmaceutical compositionhas obvious effect for preventing and treating depression. In addition, the experiment proves that clinically, a liver qi smoothing mode is employed for treating depression, a mode of warming kidney Yang also has a good curative effect, an experiment base for treating depression with a theory of warming kidney Yang clinically is provided, and the pharmaceutical composition has a wide clinical application prospect.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating depression and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Depression is a high-incidence, difficult-to-treat, chronic and relapsed mental illness, a syndrome characterized by significant and lasting depression. The clinical manifestations are depressive mood, slow thinking, reduced speech movements, low self-evaluation, and physical symptoms such as loss of appetite, decreased sexual function, and sleep disturbance, which seriously affect the quality of life and threaten life safety. In recent years, the incidence of depression has been rising sharply. According to WHO statistics, there are currently approximately 340 million depression patients in the world. It is estimated that depression will rank second in the top ten diseases in the world by 2020, second only to Ischemic heart disease. Therefore, how to effectively tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/746A61P25/24
CPCA61K36/718A61K36/296A61K36/54A61K36/746A61K2236/331A61K2236/39A61K2300/00
Inventor 江泳
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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