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Composition with whitening and acne-removing effects and its preparation method and application

A composition and a technology for acne are applied in the field of compositions with whitening and acne-removing effects and the field of preparation thereof, which can solve the problems of elevated blood lipids, liver damage, fetal malformations and the like

Active Publication Date: 2020-04-14
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whitening oral products are mostly a mixture of vitamin C, L-cysteine, nicotinamide, etc. Currently, the commonly used drug for acne treatment is isotretinoin, but oral isotretinoin is prone to cheilitis, elevated blood lipids, and liver damage , and even had side effects of fetal malformation
There is still a lack of safe and effective plant oral products with whitening and acne-removing effects

Method used

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  • Composition with whitening and acne-removing effects and its preparation method and application
  • Composition with whitening and acne-removing effects and its preparation method and application
  • Composition with whitening and acne-removing effects and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 composition of the present invention

[0035] 15 parts of Platycodon grandiflorum, 20 parts of Luo Han Guo, 10 parts of kudzu root, 20 parts of licorice, 35 parts of Angelica dahurica, after mixing, add 20 times the weight of distilled water, boil for 40 minutes to extract the filtrate; add 10 times the weight of distilled water to the filter cake, boil to extract 60min; combine the two filtrates, filter through 60 meshes; concentrate to a soluble solid content of 24% at a vacuum degree of 0.03MPa and a temperature of 70°C to obtain a composition extract, which is then freeze-dried to obtain the whitening and acne-removing effect of the present invention. Compositions. Among them, the freeze-drying conditions are: cooling at -40°C for 3 hours, vacuuming to 30Pa, gradually raising the temperature to 0°C, continuing to be under the pressure of 30Pa, and slowly raising the temperature to 60°C for 10 hours.

Embodiment 2

[0036] The preparation of embodiment 2 compositions of the present invention

[0037] 25 parts of Platycodon grandiflorum, 15 parts of Luo Han Guo, 30 parts of kudzu root, 15 parts of licorice, and 8 parts of Angelica dahurica. After mixing, add 10 times the weight of distilled water, boil and extract for 60 minutes, and take the filtrate; add 5 times the weight of distilled water to the filter cake, boil and extract 30min; the two filtrates were combined and filtered through 60 meshes; concentrated to a soluble solid content of 25% under the conditions of a vacuum degree of 0.05MPa and a temperature of 80°C to obtain a composition extract, which was then freeze-dried to obtain the whitening and anti-aging agent of the present invention. Composition for acne efficacy. Among them, the freeze-drying conditions are: cooling at -50°C for 2 hours, vacuuming to 30Pa, gradually raising the temperature to 0°C, continuing to be under the pressure of 30Pa, and slowly raising the tempera...

Embodiment 3

[0038] The preparation of embodiment 3 compositions of the present invention

[0039] 30 parts of Platycodon grandiflorum, 5 parts of Luo Han Guo, 35 parts of kudzu root, 5 parts of licorice, and 25 parts of Angelica dahurica. After mixing, add 5 times the weight of distilled water, boil and extract for 80 minutes, and take the filtrate; add 15 times the weight of distilled water to the filter cake, boil and extract 40min; the two filtrates were combined and filtered through 60 meshes; concentrated to a soluble solid content of 26% under the conditions of a vacuum degree of 0.08MPa and a temperature of 60°C to obtain a composition extract, which was then freeze-dried to obtain the whitening and anti-aging agent of the present invention. Composition for acne efficacy. Among them, carry out freeze-drying, cool at -60°C for 4 hours, evacuate to 30Pa, gradually raise the temperature to 0°C, continue under the pressure of 30Pa, after 20h, slowly raise the temperature to 70°C, and o...

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Abstract

The invention relates to the technical field of health-care food, in particular to a composition with whitening and acne-removing effects as well as a preparation method and application of the composition. According to the composition, medicinal and edible raw materials such as radix puerariae, radix platycodi, liquorice root, radix angelicae dahuricae and fructus momordicae are compounded according to specific proportions; the experiment shows that the composition provided by the invention has a significant inhibitory effect on melanin synthesis of B16 melanoma cells and activity of tyrosinase, can remarkably improve the ultraviolet-induced skin pigmentation of mice and has an obvious inhibitory effect on acne pathogenic bacteria such as propionibacterium, staphylococcus epidermidis and staphylococcus aureus; in addition, the composition has an obvious curative effect on rabbit ear acne. The results show that the composition disclosed by the invention has remarkable whitening and acne-removing effects.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a composition with whitening and acne-removing effects, a preparation method and application thereof. Background technique [0002] With the improvement of living standards, people pay more and more attention to the pursuit of beauty. Asian women have always pursued the goal of having fair and smooth skin. Acne is a common skin disorder affecting approximately 650 million people, affecting more than 95% of boys and 85% of girls in adolescents 1 . [0003] Studies have shown that Propionibacterium acnes and Staphylococcus are closely related to the pathogenesis of acne. Facial hair follicles will be accompanied by increased sebum to varying degrees after being infected with propionibacterium. When Propionibacterium colonizes the sebum unit, it induces inflammation by activating TOLL-like receptors in keratinocytes and macrophages 2 , leading to the development of acne. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q19/02A61Q19/00A61Q17/00A61P17/10A61P31/02A23L33/105
CPCA23L33/105A23V2002/00A61K8/97A61K2800/5922A61Q17/005A61Q19/00A61Q19/02A23V2200/318A23V2250/21
Inventor 刘硕汪晓凌杨宜婷钟雁陈盛魏晓丽
Owner INFINITUS (CHINA) CO LTD
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