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Application of progesterone to preparation of medicines for inhibiting expression of HIF-1alpha

A technology of HIF-1 and progesterone, applied in the field of medicine, to prevent or slow down the formation of remodeling, improve long-term survival, and reduce the expression level

Pending Publication Date: 2018-06-15
SHENZHEN EVERGREEN THERAPEUTICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the use of progesterone and its pharmaceutically acceptable derivatives for the preparation of drugs that inhibit the expression levels of hypoxia-inducible factor HIF-1α and vascular endothelial growth factor VEGF

Method used

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  • Application of progesterone to preparation of medicines for inhibiting expression of HIF-1alpha
  • Application of progesterone to preparation of medicines for inhibiting expression of HIF-1alpha
  • Application of progesterone to preparation of medicines for inhibiting expression of HIF-1alpha

Examples

Experimental program
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Effect test

Embodiment 1

[0048] This embodiment provides hypoxia-inducible factor HIF-1α inhibitors, including progesterone and pharmaceutically acceptable derivatives thereof.

[0049] The preparation method of described inhibitor is as follows:

[0050] Take progesterone and add it to DMSO solvent with a mass concentration of 1%, dissolve it, shake it for 5 minutes, and make a preparation with a final concentration of progesterone of 0.3 mg / L.

Embodiment 2

[0052] This embodiment provides hypoxia-inducible factor HIF-1α inhibitors, including progesterone and pharmaceutically acceptable derivatives thereof.

[0053] The preparation method of described inhibitor is as follows:

[0054] Take progesterone and add it to DMSO solvent with a mass concentration of 0.5%, dissolve it, shake it for 8 minutes, and prepare a preparation with a final concentration of progesterone of 0.03 mg / L.

Embodiment 3

[0056] This embodiment provides hypoxia-inducible factor HIF-1α inhibitors, including progesterone and pharmaceutically acceptable derivatives thereof.

[0057] The preparation method of described inhibitor is as follows:

[0058] Take a therapeutically effective amount of progesterone, add it to a DMSO solvent with a mass concentration of 1.5%, dissolve it, shake it for 3 minutes, and obtain the product.

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Abstract

The invention provides application of progesterone and pharmaceutically acceptable derivatives thereof to preparation of medicines for inhibiting expression of hypoxia-inducible factor HIF-1alpha. Experimental examples can prove that the progesterone and the pharmaceutically acceptable derivatives have the effect of inhibiting the expression of the hypoxia-inducible factor HIF-1alpha, can significantly reduce the expression level of the hypoxia-inducible factor HIF-1alpha, thus is of a great significance in inhibiting airway remodeling, and can also be applied to preparation of medicines for preventing or treating cancers, an abdominal aortic aneurysm (AAA) disease and bone atrophy during senescence, improving long-term survival of cancer patients, and preventing or treating rheumatoid arthritis, chronic lung diseases, pregnancy-related diseases and inflammatory intestinal diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the use of progesterone and pharmaceutically acceptable derivatives thereof in the preparation of medicines for inhibiting the expression of hypoxia-inducible factor HIF-1α. Background technique [0002] Remodeling refers to the repair of the tissue damage caused by inflammation under the condition of inflammation. If the pathogenic factors cannot be removed in time, the inflammatory factors persist or the body has an inappropriate tissue reaction, it often leads to the damage of the damaged tissue. Pathological tissue structure changes occur when the original physiological structure is completely restored. Remodeling is the result of the dynamic process of the body's repair of damaged tissue. It is the failure of normal tissue structure to recover due to repeated injury, or the abnormal repair process itself leads to permanent structural abnormalities. When tissue...

Claims

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Application Information

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IPC IPC(8): A61K31/57A61P35/00A61P29/00A61P19/08A61P19/02A61P15/00A61P11/00A61P1/00
CPCA61K31/57
Inventor 杜涛
Owner SHENZHEN EVERGREEN THERAPEUTICS CO LTD
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