Application of progesterone to preparation of medicines for inhibiting expression of HIF-1alpha
A technology of HIF-1 and progesterone, applied in the field of medicine, to prevent or slow down the formation of remodeling, improve long-term survival, and reduce the expression level
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Embodiment 1
[0048] This embodiment provides hypoxia-inducible factor HIF-1α inhibitors, including progesterone and pharmaceutically acceptable derivatives thereof.
[0049] The preparation method of described inhibitor is as follows:
[0050] Take progesterone and add it to DMSO solvent with a mass concentration of 1%, dissolve it, shake it for 5 minutes, and make a preparation with a final concentration of progesterone of 0.3 mg / L.
Embodiment 2
[0052] This embodiment provides hypoxia-inducible factor HIF-1α inhibitors, including progesterone and pharmaceutically acceptable derivatives thereof.
[0053] The preparation method of described inhibitor is as follows:
[0054] Take progesterone and add it to DMSO solvent with a mass concentration of 0.5%, dissolve it, shake it for 8 minutes, and prepare a preparation with a final concentration of progesterone of 0.03 mg / L.
Embodiment 3
[0056] This embodiment provides hypoxia-inducible factor HIF-1α inhibitors, including progesterone and pharmaceutically acceptable derivatives thereof.
[0057] The preparation method of described inhibitor is as follows:
[0058] Take a therapeutically effective amount of progesterone, add it to a DMSO solvent with a mass concentration of 1.5%, dissolve it, shake it for 3 minutes, and obtain the product.
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