Medicinal composition for preventing and treating dental caries and preparation method and application of medicinal composition
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A technology of composition and medicine, which is applied in the field of pharmaceutical composition for prevention and treatment of dental caries, can solve problems such as unsatisfactory use effect, and achieve the effects of low cost, promotion of remineralization, and simple preservation
Inactive Publication Date: 2018-07-24
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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Embodiment 1
[0034] The preparation of embodiment 1 chitosan sodium fluoride gel
[0035] Raw materials: chitosan powder with 75% deacetylation degree, sodium β-glycerophosphate, sodium fluoride, hydrochloric acid
[0036] The preparation method is as follows:
[0037] 1.1 Solution preparation
[0038] 1.1.1 Prepare 100ml of 0.05mol / L hydrochloric acid;
[0039] 1.1.2 Add chitosan and stir at room temperature for 24 hours to prepare a saturated chitosan hydrochloric acid solution. Centrifuge, remove excess chitosan powder, keep supernatant;
[0040] 1.1.3 Put the chitosan supernatant into the jar, sterilize it by high-pressure steam for 30 minutes, let it cool down to normal temperature, and put it in a 4-degree refrigerator for later use;
[0041] 1.1.4pH meter to measure the pH value of chitosan hydrochloric acid solution;
[0042] 1.1.5 Prepare 56% w / v sodium β-glycerophosphate solution with deionized water.
[0043] 1.2 Preparation of chitosan sodium fluoride gel
[0044] 1.2.1 ...
Embodiment 2
[0045] Embodiment 2 chitosan sodium fluoride gel correlation experiment
[0046] 1.1 Solution preparation
[0047] 1.1.1 Prepare 100ml of 0.05mol / L hydrochloric acid;
[0048] 1.1.2 Add chitosan and stir at room temperature for 24 hours to prepare a saturated chitosan hydrochloric acid solution. Centrifuge, remove excess chitosan powder, keep supernatant;
[0049] 1.1.3 Put the chitosan supernatant into the jar, sterilize it by high-pressure steam for 30 minutes, let it cool down to normal temperature, and put it in a 4-degree refrigerator for later use;
[0050] 1.1.4 pH meter to measure the pH value of chitosan hydrochloric acid solution;
[0051] 1.1.5 Prepare 56% w / v sodium β-glycerophosphate solution with deionized water.
[0052] 1.2 Preparation and detection of chitosan sodium fluoride gel
[0053] 1.2.1 Take 2ml chitosan hydrochloric acid solution, 0.1894gNaF, add 1.2ml beta-glycerophosphate sodium solution drop by drop, stir evenly under ice-water bath, and prepa...
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Abstract
The invention provides a medicinal composition for preventing and treating dental caries. The medicinal composition is gel made of chitosan, beta-sodium glycero-phosphate and sodium fluoride as main components. The invention further provides a preparation method of the gel. The preparation method comprises the following steps: 1) dissolving chitosan into a 0.05mol / L medicinal composition hydrochloric acid solution so as to obtain a saturated chitosan-hydrochloric acid solution, performing high-temperature sterilization, and cooling to a normal temperature for later use; 2) preparing a 56%w / v beta-sodium glycero-phosphate solution from deionized water; 3) putting sodium fluoride into the saturated chitosan-hydrochloric acid solution prepared in the step 1), dropping the beta-sodium glycero-phosphate solution prepared in the step 2), and uniformly stirring in an icy water bath, so as to obtain chitosan-sodium fluoride gel. The medicinal composition for preventing and treating dental caries, which is provided by the invention, is relatively low in cost when being compared with duraphat, in addition, tests show that acid erosion of teeth can be effectively inhibited, and remineralization of dental caries can be promoted, in addition, the composition is simple to preserve and convenient to use, and applicable to wide clinical popularization and application.
Description
technical field [0001] The invention relates to the field of pharmacy, in particular to a pharmaceutical composition for preventing and treating dental caries, and also relates to a preparation method and application of the pharmaceutical composition. Background technique [0002] Commonly known as caries and tooth decay, caries is a bacterial disease, which can be secondary to pulpitis and periapical periodontitis, and even cause alveolar bone and jaw inflammation. If it is not treated in time, the lesion will continue to develop, forming cavities, and eventually the crown will be completely destroyed and disappeared. The final result of its development is tooth loss. Caries is characterized by high incidence and wide distribution. It is the main common disease of the oral cavity and one of the most common diseases of human beings. The World Health Organization has listed it as the three major diseases of human beings, along with tumors and cardiovascular diseases. [000...
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