76results about "Fluorine compound active ingredients" patented technology

Disclosed are free-flowing, water-soluble dentifrice granules which are printed and dried to have a uniform size, weight and density, and fast dissolution time.

To provide a compound comprising a cyclic peptide and a chelator, and its use.SOLUTION: The present invention provides a compound selected from the group consisting of compound Hex-[Cys(tMeBn(DOTA-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH (3BP-3554) and compound Hex-[Cys(tMeBn(DOTA-PP))-Pro-Pro-Thr-Gln-Phe-Cys]-Asp-NH2 (3BP-3407).SELECTED DRAWING: None

A method of treating gingivitis in a subject by administering a therapeutically effective amount of a thickened silver diamine fluoride composition to a tooth, wherein said silver diamine fluoride composition comprises silver diamine fluoride and has at least one of the following features: (A) the silver diamine fluoride composition is thixotropic and has a viscosity of 0.02 to 500 Pa·s, as measured by a TA AR-G2 rheometer with a 40 mm cone and plate, and carried out at a temperature of about 23⁰C, and a shear rate of from 0.1 / second to 100 / second; and (B) the silver diamine fluoride composition comprises a thickening agent, wherein the thickening agent is in an amount of 0.1 wt.% to 15 wt.%, based on a total weight of the composition.

The invention belongs to the field of pharmaceutical preparations, and relates to a multi-trace element injection and a preparation method thereof. The multi-trace element injection comprises effective components, a stabilizer and water, the effective components comprise chromium chloride, copper chloride, ferric chloride, manganese chloride, sodium molybdate, sodium selenite, zinc chloride, potassium iodide and sodium fluoride, and the stabilizer comprises xylitol, a pH regulator and an additive; and the additive is PEG (Polyethylene Glycol) 400 or PEG 600. The multi-trace element injection provided by the invention can effectively inhibit the loss of iodine in the sterilization process, and the stability, economical efficiency and production controllability of the multi-trace element injection are fundamentally improved.

The invention provides a pH response type MOF (Metal Organic Framework) material, a composite photosensitive resin system containing the pH response type MOF material and application of the pH response type MOF material in a dental appliance. The pH response type MOF material is a multifunctional metal organic framework material (Guardian-MOF) with a'core-shell-satellite 'structure, the MOF is chemically bonded into a light-cured resin matrix to form intelligent composite resin capable of 3D / 4D printing, and a prepared orthodontic appliance has required mechanical properties macroscopically so as to complete an orthodontic function, and has the advantages of being simple in preparation process, low in cost and the like. The oral cavity antibacterial and targeted remineralization treatment system is a distributed and intelligent'micro clinic 'microcosmically, can accurately respond to an oral cavity pathogenic microenvironment (low pH) and cooperatively execute multiple antibacterial and targeted remineralization treatment, and has a remarkable application prospect.

Compositions and methods are provided for treating dental caries in individuals and animals. The compositions may be zinc compositions of [Zn(NH3)4]F2. Also provided are methods for producing inorganic zinc compounds (e.g., ZnO, Zn(OH)2, or Zn(OH)F) on the surface of carious lesions. The deposition of inorganic zinc compounds (e.g., ZnO, Zn(OH)2, or Zn(OH)F) reduces the amount of Zn 2+ This can occur by diluting a ZnO / NH3 solution (e.g., an aqueous or alcohol-based solution) into water (e.g., deionized water). The formation of inorganic zinc compounds (e.g., ZnO, Zn(OH)2, or Zn(OH)F) can occur instantaneously upon dilution.

Compositions for the treatment of acute manifestations because of oxidative injury by reactive oxygen species (ROS) and chronic development of fibrosis are provided. Compositions of the present invention include perfluorocarbon, hydrogen and oxygen gas, N-acetylcysteine, and glycine to counter robust oxidative responses unleashed following injury from both mechanical and non-mechanical conditions. Methods are also disclosed for delivery to challenging locations (olfactory cleft, spinal canal) and in hostile conditions (post trauma brain, spine, and upper and lower airways), with the invention's products "calming" inflamed tissue by neutralizing ROS in both acute and later complications. Active pharmaceutical ingredient(s) can also be employed to provide both acute and chronic benefit, and such active ingredients themselves can be augmented by the composition, enabling increased drug uptake and oxygenation. The present invention provides broad relief in many conditions for both human and companion subjects.

The present invention relates to a highly fluid, crosslinkable medical or dental composition comprising a crosslinking compound, a polymerization initiator, and a heterogeneous radiation opacifier. Also disclosed are a crosslinked polymer composition obtained by crosslinking the highly fluid, crosslinkable medical or dental composition, and the use of the highly fluid, crosslinkable medical or dental composition for filling cavities or hollow structures in human or animal subjects.

The invention includes a toothpaste or other orally applied product to be used at least once daily to help prevent or inhibit the acquisition of a number of infections by oral or pharyngeal tissues, particularly including the "common" cold. These compositions possess a combination of ingredients that is not found in other toothpastes or other orally applied products, and these ingredients work together to synergistically interfere with the acquisition of a number of pathogens. The toothpastes will have the usual dentifrice ingredients known to prevent tooth decay, as well as those that reduce halitosis (i.e., bad breath), and prevent gingivitis. In addition, the toothpastes will include one or more of: 1) GALALCOOL® as an individual compound, and not as an extract component; 2) zinc protoporphyrin IX; and 3) one or more other colorless or low-color tannin(s) each as an individual compound, and not as an extract component.

To provide a glass composition for dentin desensitizing compositions.SOLUTION: The present disclosure provides a glass composition that includes: from about 50 mol% to about 95 mol% of B2O3; and from about 5 mol% to about 50 mol% of one or more glass components selected from the group consisting of: Li2O, Rb2O, K2O, Na2O, SrO, CaO, MgO, and ZnO. The glass composition includes less than 30 mol% of Rb2O. The glass composition is a quaternary system. The glass composition is a particulate material that includes particles that are from about 1 to about 50 μm in size. The glass composition loses at least 5 mass% within 24 hours when exposed to a buffered saline solution. The glass composition may be used to desensitize dentin. The present disclosure also provides a dentin desensitizing composition.SELECTED DRAWING: None

This disclosure relates to targeting moieties, such as peptides and antibodies, that can bind to DLL3. The disclosure also provides targeted constructs, which may include a targeting moiety conjugated to a chelating agent for cargo association via an optional linker. Methods for constructing the constructs and formulations thereof are also provided. Methods for using the constructs and / or formulations to treat a target, for example, to treat or prevent cancer, are also described.

The invention relates to the technical field of pharmaceutical compositions, and discloses an anti-caries composition containing taxifolin as well as a preparation method and application of the anti-caries composition containing taxifolin, the anti-caries composition containing taxifolin comprises taxifolin and sodium fluoride, and the concentration ratio of taxifolin to sodium fluoride is 1mg / mL: 700ppm. Under the concentration, taxifolin and sodium fluoride generate a mutual promotion synergistic effect, and sodium fluoride obviously enhances the bacteriostatic action of taxifolin, obviously prolongs the growth delay phase of streptococcus mutans and reduces the viable count peak value in the logarithmic phase; the inhibition rate on biofilm formation is 57.4 + / -2.1%, and the antibacterial effect is remarkably enhanced; meanwhile, taxifolin enhances the demineralization resistance of sodium fluoride, and the demineralization resistance effect of only 700ppm of sodium fluoride is obviously superior to that of 1000ppm of sodium fluoride. The method disclosed by the invention has more excellent bacteriostatic activity, higher demineralization resistance and higher biological safety, and has great popularization and application values.

The invention discloses a pharmaceutical composition for delaying senescence and resisting oxidation, and belongs to the technical field of biological medicine and health food. The composition comprises vitamin A, beta-carotene, vitamin complex B, vitamin C, vitamin D, vitamin E, vitamin k, macroelements including calcium, phosphorus, potassium and magnesium, microelements including zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese, traditional Chinese medicines including ginseng, astragalus membranaceus, fructus lycii and radix polygoni multiflori preparata, and condition essential nutrient nucleic acid. The bioactive components comprise lycopene, tea polyphenol, taurine, lutein, lutein fat, zeaxanthin, chlorophyll and the like; is mainly suitable for middle-aged and elderly people; the composition eliminates multiple factors causing aging from multiple systems, multiple links and multiple targets, can significantly delay aging, has health-care and tonifying effects such as oxidation resistance, and can improve the life quality of middle-aged and elderly people while delaying aging; the composition has no incompatibility, and does not generate any toxic or side effect after being taken for a long time.

To provide compositions that are simply applied to teeth as varnishes and work in a short time like gel / foam formulations, and methods for treatment.SOLUTION: An aqueous oral care fluoride treatment composition is disclosed, wherein the composition includes: 0.1 wt.% to 3.0 wt.% of a crosslinked poly acid having carboxylic acid side groups; a pharmaceutically acceptable buffer; 1.0 wt.% to 2.5 wt.% of sodium fluoride; 0.025 wt.% to 1.75 wt.% of a multivalent cation salt; and at least 60 wt.% water; wherein the weight percentages are based on the total weight of the aqueous composition. Also disclosed are a method of providing fluoride to a patient's tooth surface, and a method of reducing the incidence of dental caries.SELECTED DRAWING: None

The application provides a nano-enzyme with sterilization, tooth desensitization and remineralization functions, and a preparation method and application thereof, and relates to the technical field of nano-enzymes. 2+ The three are self-assembled into multifunctional BHCF nano-enzymes with sterilization, tooth desensitization and remineralization functions through multi-dimensional interactions of ionic bonds, Ca The BHCF nano-enzyme has clear peroxidase-like and superoxide dismutase-like dual-enzyme catalytic capacity and a photodynamic effect. Under light conditions, the antibacterial activity of the BHCF nano-enzyme is significantly activated, and the sterilization rate can reach 99.995 %. Meanwhile, the BHCF nano-enzyme has good immediate and persistent sealing effects, excellent acid resistance and wear resistance, and remineralization capacity. The BHCF nano-enzyme provided by the application has great application potential in the preparation of drugs for treating periodontitis.

The present disclosure provides an anti-caries anhydrous gel, a preparation method therefor, and use thereof, and a tubular anti-caries anhydrous gel, relating to the technical field of dental gels. According to the present disclosure, polyethylene glycol and / or glycerol as well as absolute ethanol are used as an anhydrous matrix, thereby achieving coexistence of a bioactive material and a high-concentration fluorine ion source; by adding a hydrophobic copolymer as a film-forming agent, the anti-caries anhydrous gel can immediately form a layer of transparent film on the tooth surface after being applied to the teeth, so that effective components are controlled to be slowly released, thereby prolonging the action time of the anti-caries gel on the teeth, improving the remineralization effect of the anti-caries gel, and solving defects of traditional remineralization products such as dissolution after encountering saliva, which leads to short residence time on the tooth surface and thus causes local remineralization-promoting ions to be insufficient due to loss. By adding an antibacterial agent, formation of a dental plaque biofilm can be inhibited by means of the slow-release effect, thereby avoiding aggravation of white spot lesions caused by dental plaque accumulation, which is more conducive to preventing and treating orthodontic white spots during the correction treatment period.

The invention discloses a pharmaceutical composition for preventing birth defects and improving memory, and belongs to the technical field of biological medicine and health food. The composition comprises vitamin A, beta-carotene, vitamin complex B, vitamin C, vitamin D, vitamin E, vitamin k, macroelements including calcium, phosphorus, potassium and magnesium and microelements including zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese, traditional Chinese medicines including glossy privet fruit, astragalus membranaceus, fructus lycii, semen cuscutae and nucleic acid, and bioactive components including lutein, lutein fat, zeaxanthin, grape seed extract, chlorophyll and taurine. The device is mainly used for pre-pregnancy preparation of pregnant women, dosages thereof, pregnant women and wet nurses. The composition eliminates various factors causing birth defects from multiple systems, multiple links and multiple targets, can significantly reduce the total occurrence rate of birth defects, has the effect of improving memory, is beneficial to the health of parents and children, has no incompatibility, and does not generate any toxic or side effect after being taken for a long time.

A method for binding an active substance or an active agent to an activated autologous blood nosode comprises a) dissolving blood of a patient in an aqueous or aqueous / ethanol medium or rubbing the blood of a patient with a carrier material approved for globules according to Germany's Homeopathic Pharmacopeia (HAB) to obtain a first mixture; b) activating the first mixture by reaction with magnetic pulses having frequencies of the magnet field periods within a range of approximately 0.01 to approximately 20,0000 Hz and maximum field strengths of 50 μΤ onto the first mixture; c) adding one, or one or more active substances and / or active agents to the activated first mixture to obtain a second mixture; d) succussion of the second mixture by mechanical effects, wherein the steps c) and d) are conducted under the continuous effects of the magnet pulses and wherein steps c) and d) can be repeated once or several times; and e) activating the succussed second mixture by the further continuous effect of the magnet pulses and by irradiation with visible light of changing colors produced by LEDs into the second succussed mixture, whereby an increase of the binding capacity of the human serum albumin (HSA) in the blood to the active substance(s) and / or to at least some of the active agent or active agents is effected. A device for carrying out the method is also described.

The purpose of this disclosure is to provide a glass composition for dentin desensitization compositions. [Solution] This disclosure provides a glass composition comprising about 50 mol% to about 95 mol% of B2O3; and about 5 mol% to about 50 mol% of one or more glass components selected from the group consisting of Li2O, Rb2O, K2O, Na2O, SrO, CaO, MgO, and ZnO. The glass composition contains less than 30 mol% of Rb2O. The glass composition is a four-component system. The glass composition is particulate matter containing particles with a size of about 1 to about 50 μm. When exposed to a buffered saline solution, the glass composition loses at least 5% by mass within 24 hours. The glass composition can be used to desensitize dentin. This disclosure also provides a dentin desensitization composition.

The purpose of this disclosure is to provide a glass composition for dentin desensitization compositions. [Solution] This disclosure provides a glass composition comprising about 50 mol% to about 95 mol% of B2O3; and about 5 mol% to about 50 mol% of one or more glass components selected from the group consisting of Li2O, Rb2O, K2O, Na2O, SrO, CaO, MgO, and ZnO. The glass composition contains less than 30 mol% of Rb2O. The glass composition is a four-component system. The glass composition is particulate matter containing particles with a size of about 1 to about 50 μm. When exposed to a buffered saline solution, the glass composition loses at least 5% by mass within 24 hours. The glass composition can be used to desensitize dentin. This disclosure also provides a dentin desensitization composition.

The application relates to application of a hyaluronic acid-based hydrogel in preparation of a fluorine ion slow-release agent, the fluorine ion slow-release agent being prepared by mixing a precursor solution of the hyaluronic acid-based hydrogel with a fluorine source on site, the precursor solution of the hyaluronic acid-based hydrogel comprising an A component and a B component, a preparation method of the A component comprising the following steps: S1. mixing and reacting methyl methacrylate group modified hyaluronic acid and furfurylamine to obtain furan-methyl methacrylate modified hyaluronic acid; S2. mixing and reacting the furan-methyl methacrylate modified hyaluronic acid and maleimide to obtain double-modified group hyaluronic acid; S3. mixing the double-modified group hyaluronic acid, a photoinitiator and a solvent to obtain the A component; and the B component is a mercapto polyethylene glycol solution. The fluorine ion slow-release agent not only has a fast gelation speed, but also can be self-healed to form a gel in different ways, and can release fluorine ions stably and long-acting after gelation, and can be used for preventing and treating enamel demineralization or enamel defects.

A phosphorous compound such as STMP is used as a cross-linking agent while making a starch nanoparticle in an emulsion process. Negative charge of the nanoparticle is reduced or reversed by adding cations and / or cationizing the starch optionally while forming the nanoparticles. Anionic active agents, such as fluoride or fluorescein, are optionally incorporated into the nanoparticle during the formation process. For example, a fluoride salt can also be used, which promotes the crosslinking reaction while also providing fluoride in the nanoparticle. The retention of both calcium and fluoride in the nanoparticle is improved when both salts are used. Alternatively, the nanoparticle may be used without added calcium and / or fluoride. The nanoparticles may be useful for tooth remineralization, the treatment of dentinal hypersensitivity, to treat caries, or as a diagnostic agent to locate carious lesions.

To provide a dentin hypersensitivity-suppressing composition enabling easy retention on a tooth surface.SOLUTION: The dentin hypersensitivity-suppressing composition comprises, based on the composition, 0.3 mass% or more and 5.0 mass% or less of aluminum lactate, 3.0 mass% or more and 6.5 mass% or less of a polymer containing a carboxyl group, and 0.05 mass% or more and 7.0 mass% or less of a chelating agent.SELECTED DRAWING: None

Provided is compositions and methods for treating dental caries in individuals and animals. The compositions may be zinc compositions of [Zn(NH3)4]F2. Also provided are methods of making inorganic zinc compounds (e.g., ZnO, Zn(OH)2, or Zn(OH)F) onto the surface of a carious lesion. The deposition of inorganic zinc compound (e.g., ZnO, Zn(OH)2, or Zn(OH)F) may occur from dilution of a Zn2+ / NH3 solution (e.g., an aqueous or alcohol-based solution) into water (e.g., deionized water). The formation of inorganic zinc compound (e.g., ZnO, Zn(OH)2, or Zn(OH)F) may be instantaneous upon dilution.

A stable trace element composition, its preparation method, and its use are disclosed. The trace element composition comprises a main material and auxiliary materials. The main material comprises pharmaceutical organic acid salts of iron, zinc, copper, and manganese, pharmaceutical salts of fluorine, iodine, selenium, and molybdenum, and a pharmaceutical organic or inorganic salt of chromium. The auxiliary materials comprise water for injection and a pH adjuster, which is an inorganic acid. The pH value of the trace element composition is 2.0 to 3.5. The amount of each trace element per 10 mL of the trace element composition is (unit: μmol): 17.8 to 21.5 μmol iron, 40 to 100 μmol zinc, 4.7 to 9.6 μmol copper, 1 μmol manganese, 25 to 60 μmol fluorine, 0.5 to 1.2 μmol iodine, 0.75 to 1.27 μmol selenium, 0.2 to 0.26 μmol molybdenum, and 0.2 to 0.4 μmol chromium.

The invention relates to a tumor endoplasmic reticulum targeted rare earth nano diagnosis and treatment integrated preparation as well as a preparation method and application thereof. The rare earth nano diagnosis and treatment integrated preparation comprises rare earth core-shell nanoparticles as well as tumor targeted peptide and endoplasmic reticulum signal peptide which are loaded on the surfaces of the rare earth core-shell nanoparticles, the rare earth core-shell nanoparticles comprise rare earth nanoparticles NaYbF4: Er / Ce / Zn and CaF2 covering the surface of the NaYbF4. The rare earth nano diagnosis and treatment integrated preparation can depend on accurate endoplasmic reticulum targeted Ca release to induce tumor cell calcium overload, so that immunogenic cell death is triggered, and anti-tumor immune response is activated; meanwhile, by means of the stable NIR-II region fluorescence characteristic of the rare earth nanoparticles, high-sensitivity imaging and real-time monitoring of tumor focuses are achieved, and the integrated advantage of precise diagnosis and efficient treatment is achieved.

The present invention relates to X-ray amorphous and hollow calcium magnesium fluoride phosphate particles. The X-ray amorphous and hollow calcium magnesium fluoride phosphate particles have a mean diameter ranging from 50 to 500 nm and comprise a respective shell. The respective shell comprises 15-30 wt% calcium, 50-65 wt% phosphate, 4-8 wt% magnesium, 1-10 wt% fluoride, and the balance is water.

The present invention relates to polymer strips and compositions for use in oral care and various methods of their use. In particular, it relates to compositions comprising phosphoproteins and their use in the treatment and prevention of bleeding gums and the treatment and prevention of periodontal disease. Preferred compositions comprise osteopontin and derivatives thereof.