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Use of osteocalcin for preparing medicine for treating Parkinson's diseases

A technology for Parkinson's disease and osteocalcin, applied in drug combinations, pharmaceutical formulations, neurological diseases, etc., can solve symptom fluctuations and dyskinesias, heavy burdens on families and society, and affect the physical and mental health and quality of life of the elderly, etc. question

Active Publication Date: 2018-07-27
SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both seriously affect the physical and mental health and quality of life of the elderly, and bring heavy burdens to families and society
The existing therapeutic drugs can only improve some motor symptoms of PD to a certain extent, but cannot reverse the neurodegenerative process, and long-term use can lead to complications such as symptom fluctuations and dyskinesias

Method used

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  • Use of osteocalcin for preparing medicine for treating Parkinson's diseases
  • Use of osteocalcin for preparing medicine for treating Parkinson's diseases
  • Use of osteocalcin for preparing medicine for treating Parkinson's diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] This embodiment relates to the use of osteocalcin to prepare a medicine for treating Parkinson's disease. The specific mechanism research test is as follows:

[0022] Rats used: 250-290g male, healthy and clean SD rats, purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0023] SD rat feeding conditions: ambient temperature 22±0.5 degrees, 12 hours / 12 hours light and dark alternately.

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PUM

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Abstract

The invention discloses a use of osteocalcin for preparing medicine for treating Parkinson's diseases. The effects that exogenous application of the osteocalcin can relieve the dyskinesia of a rat model with the Parkinson's diseases and can reduce the substantia nigra dopaminergic neuron loss, and the PC12 cell apoptosis caused by 6-OHDA can be reduced through AKT / GSK path in vitro. Therefore theosteocalcin as a small molecule polypeptide hormone capable of passing through blood brain barrier can become fire-new medicine for preventing and treating the occurrence and the development of the Parkinson's diseases.

Description

technical field [0001] The invention belongs to the field of medical preparation, and in particular relates to the use of osteocalcin to prepare a drug for treating Parkinson's disease. Background technique [0002] The aging process of the body is usually accompanied by different degrees of bone density decline and neurodegeneration. Osteoporosis and Parkinson's disease (Parkinson's Disease, PD) are common elderly comorbid diseases, and clinical studies have shown that PD is an important factor that increases the risk of fracture. Osteoporosis results from a disruption of the balance between osteogenic formation and osteoclastic resorption, leading to structural destruction of bone, increased fragility, and increased risk of fracture; while Parkinson's disease is the most common neurodegenerative movement disorder, affecting about 1% of For people over 60 years old, the disease is related to the significant loss of dopaminergic neurons in the substantia nigra compacta, man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P25/16
CPCA61K38/1709
Inventor 刘建民郭兴志李胜天单畅赵红燕孙立昊陶蓓
Owner SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES
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