Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2o2 level in cancer cells of a subject

A technique of H2O2, a subject, applied in the field of combination comprising an aminothiol ester compound or a pharmaceutically acceptable salt thereof, and a compound capable of increasing the level of H2O2 in a cancer cell of a subject, capable of resolving elevated etc. question

Pending Publication Date: 2018-07-31
ADVANCED BIODESIGN
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  • Abstract
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  • Claims
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Problems solved by technology

However, if a compound is able to increase H in both normal and cancer cells 2 o 2 levels, when administered this compound was able to increase H in the subject's cancer cells 2 o 2 At the same time, H in normal cells 2 o 2 levels will increase concomitantly

Method used

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  • Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2o2 level in cancer cells of a subject
  • Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2o2 level in cancer cells of a subject
  • Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H2o2 level in cancer cells of a subject

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Experimental program
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Embodiment Construction

[0198] specific implementation plan

[0199] Materials and methods

[0200] cell line

[0201] A panel of 52 human tumor cells representing 10 tissue types has been screened to cover a broad set of different oncogenes and by their response to different standard chemotherapeutic agents. Cells were obtained from American Type Culture Collection (ATCC), European Collection of Cell Cultures (ECACC) and primary cultures of cancer cells from patient tumors (Research Institute of Vall d' Hebron (VHIR), Barcelone, Spain; Vall d'Hebron Institute of Oncology (VHIO), Barcelone, Spain; Oncotest, Freiburg, Germany; Oncodesign, Dijon, France; Universitá Degli Studi di Palermo, Oncology and Surgical Sciences, Palermo, Italy; and Institute of Predictive and Personalized Medicine of Cancer (IMPPC), Barcelona, ​​Spain (see Table 3 for tumor cell panel descriptions). All cells were cultured in appropriate media according to the supplier's recommendations.

[0202] table 3

[0203]

[0204...

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Abstract

Provided is a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the H 2 0 2 level in cancer cells of a subject, for use as a medicament. The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H2 0 2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H 2 0 2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.

Description

technical field [0001] The present invention relates to compounds containing aminothiol esters or pharmaceutically acceptable salts thereof, particularly S-methyl 4-(dimethylamino)-4-methylpent-2-yne thioester or pharmaceutically acceptable salts thereof Acceptable salts, and more specifically 4-(dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, are capable of increasing h 2 o 2 Combinations of compounds at levels particularly useful for treating cancer in a subject, wherein the subject's cancer cells do not overproduce H as compared to control values 2 o 2 , and had GSH levels below 0.5 nmol for 25000 cells. Background technique [0002] The redox balance of cells is critical to normal cell physiology. It is maintained by 3 systems: GSH / GSSG; NADPH / NADP; Thioredoxin (reduction) / thioredoxin (oxidation). Of the three systems, GSH / GSSG has been most extensively studied due to its involvement in disease states and the development of rational treatments...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/131A61K31/136A61K31/137A61K31/4453A61K31/498A61K31/5375A61K31/704A61K33/24A61K33/36A61P35/00G01N33/50
CPCA61K45/06A61K31/131A61K31/136A61K31/137A61K31/4453A61K31/498A61K31/5375A61K31/704A61K33/36G01N33/57496G01N33/68G01N33/84G01N2440/00A61P35/02A61K31/145A61K2300/00A61K33/24G01N21/64
Inventor I·塞兰G·夸什M·派瑞兹-阿里尔G·马丁
Owner ADVANCED BIODESIGN
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