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Zeylenone inhibiting gastric carcinoma cell proliferation, invasion, migration and apoptosis induction

A technology for gastric cancer cells and gastric cancer, which is applied in the fields of Zeylenone inhibiting the proliferation, migration, induction of apoptosis and invasion of gastric cancer cells, and can solve problems such as accelerated metastasis

Inactive Publication Date: 2018-08-10
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, MMP-2 and MMP-9 can degrade most of the ECM components, leading to accelerated transfer

Method used

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  • Zeylenone inhibiting gastric carcinoma cell proliferation, invasion, migration and apoptosis induction
  • Zeylenone inhibiting gastric carcinoma cell proliferation, invasion, migration and apoptosis induction
  • Zeylenone inhibiting gastric carcinoma cell proliferation, invasion, migration and apoptosis induction

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Embodiment 1, the application of Zeylenone in the treatment of gastric cancer

[0051] 1. Preparation of test compounds

[0052] The test compound Zeylenone (hereinafter referred to as Zey) was prepared into a 10 mg / mL stock solution with DMSO as a solvent, and stored in a refrigerator at -20°C. When in use, dilute to the concentration required for the experiment with cell culture medium, wherein the final concentration of DMSO is <0.1%.

[0053]Preparation method of Zeylenone nanomicelle: Precisely weigh 3.50mg of Zeylenone and 100.00mg of mPEG2000-PDLLA2000 (Jinan Daigang Bioengineering Co., Ltd.) : 100, when it is greater than, the dosage increases and the drug loading decreases instead), add 2ml of dichloromethane solution, and ultrasonically disperses and mixes the amphiphilic material and the hydrophobic drug in the organic solution. After the amphoteric material and hydrophobic drug are completely dissolved, the organic solvent is removed by rotary evaporation ...

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Abstract

The invention discloses a Zeylenone inhibiting gastric carcinoma cell proliferation, invasion, migration and apoptosis induction, and provides application of the Zeylenone or nano-micelle thereof in preparing at least one kind of products of 1) a product treating or preventing gastric carcinoma, 2) a product inhibiting gastric carcinoma cell proliferation or growth, 3) a product inducing gastric carcinoma cell apoptosis and 4) a product inducing gastric carcinoma cell invasion and / or migration. The Zeylenone inhibiting gastric carcinoma cell proliferation, invasion, migration and apoptosis induction has the advantages that it is firstly found that Zey can inhibit gastric carcinoma cell invasion, migration and apoptosis induction, so zey is a very potential therapeutic drug, certainly caninhibit the growth of the gastric carcinoma and has a pharmaceutical effect of anti-tumor in vivo.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a Zeylenone for inhibiting gastric cancer cell proliferation, invasion, migration and inducing apoptosis. Background technique [0002] Gastric cancer has gradually become a health threat because of its fourth incidence rate and second mortality rate. Studies have shown that there are more than 950,000 cancer cases every year, of which 720,000 patients die of gastric cancer. Therefore, the disease burden of gastric cancer remains high, especially in Asia, Latin America, and Central and Eastern Europe. It is worth noting that uncontrolled cell proliferation, invasion and metastasis are the main clinical features of gastric cancer. Therefore, most patients die not from primary cancer but from metastatic cancer. However, in the treatment strategy of gastric cancer, research in the field of metastasis is relatively lagging behind. Therefore, in this case, finding a new dr...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K9/107A61P35/00A61P1/00
CPCA61K9/1075A61K31/216A61P1/00A61P35/00
Inventor 曹丽杨淑贤李立勇
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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