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Application of common curculigo rhizome and epimedium herb decoction to preparation of antidepressive drugs

An Erxian Decoction, antidepressant technology, applied in the field of medicine, can solve the problems of many side effects, long onset time, unsatisfactory and other problems, and achieve the effect of great application value and fast onset time

Inactive Publication Date: 2018-08-28
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the mechanism of action of almost all antidepressants mainly involves the transmission of monoamine neurotransmitters, relatively many side effects, clear curative effect, but not satisfactory, for example, some patients are ineffective to almost all antidepressants, almost all antidepressants The onset time of depression drugs is relatively long, and it takes at least 2 weeks to take effect, etc.

Method used

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  • Application of common curculigo rhizome and epimedium herb decoction to preparation of antidepressive drugs
  • Application of common curculigo rhizome and epimedium herb decoction to preparation of antidepressive drugs
  • Application of common curculigo rhizome and epimedium herb decoction to preparation of antidepressive drugs

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Embodiment Construction

[0026] The embodiments of the present invention are described in detail below. This embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following implementation example.

[0027] In the quantitative test of this embodiment, three repeated experiments were set up, and p<0.05 was used as the standard of significant difference for all results.

[0028] 1. In vitro cell experiment of Erxian Decoction: protective effect on PC12 nerve cells

[0029] 1. Experimental materials

[0030] PC12 cells (Shanghai Cell Bank, Chinese Academy of Sciences); DMSO (Sigma, USA); DMEM (Nanjing Kaiji Biotechnology Development Co., Ltd.); corticosterone (Jiangsu Jiaerke Pharmaceutical Group Co., Ltd.); Co., Ltd.); fluoxetine hydrochloride (Shanghai Aladdin Biochemical Technology Co., Ltd.);

[0031] 2. Ex...

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Abstract

The invention discloses the application of common curculigo rhizome and epimedium herb decoction to the preparation of anti-depressive drugs. The application of the common curculigo rhizome and epimedium herb decoction is as follows: preparation of anti-depressive drug; preparation of drug for preventing depression; and preparation of drug for treating depression. The ingredients of the common curculigo rhizome and epimedium herb decoction is prepared from common curculigo rhizome, epimedium herb, medicinal indianmulberry root, Chinese angelica root, amur corktree bark and common anemarrhena rhizome. The application of the traditional medicine (common curculigo rhizome and epimedium herb decoction) to the preparation of the antidepressive drugs is protected by the invention, the common curculigo rhizome and epimedium herb decoction medicine has an antidepressive characteristic, and moreover, the common curculigo rhizome and epimedium herb decoction can take effect in a short time, andhas great application value in the development of anti-depressive drugs and the prevention and treatment of depression.

Description

technical field [0001] The invention relates to a medical technology, in particular to the application of Erxian Decoction in the preparation of antidepressant drugs. Background technique [0002] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. It can be seen clinically that the mood is not commensurate with the situation. The emotional depression can range from gloomy to distraught, even pessimistic and world-weary. There may be suicide attempts or behaviors; even stupor; some cases have obvious anxiety and motor agitation; severe cases may Psychotic symptoms such as hallucinations and delusions appear. Each attack lasts for at least 2 weeks, or even several years in the elderly. Most cases have a tendency to recur. Most of each attack can be relieved, and some may have residual symptoms or become chronic. [0003] Antidepressive drugs refer to a group of psychiatric dr...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/24
CPCA61K36/232A61K36/296A61K36/746A61K36/756A61K36/88A61K36/8964A61K2236/331A61K2236/39A61P25/24A61K2300/00
Inventor 李宁张蓝葛金芳
Owner ANHUI MEDICAL UNIV
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