Thalamus nucleus partitioning method based on global connection characteristics and geodesic distance

A technology of connection features and geodesic distance, applied in the field of digital images, can solve problems such as the connection between the thalamus and cortical brain areas, and achieve the effect of reducing noise and good robustness

Pending Publication Date: 2018-09-28
SOUTHEAST UNIV
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Problems solved by technology

In the traditional method, the use of rs-fMRI to partition the thalamus mainly uses the prior seed point method based on functional connectivity. This method requires prior partition knowledge of the cortex. The currently known cortical templates include Automated Anatomical Labeling (AAL ) template, Harvard-Oxford (HO) template, etc., Fan et al. used the time series correlation between thalamic voxels as a feature to cluster the thalamus, but only used the local information of thalamic voxels without considering the thalamus and cortical brain Connectivity between districts

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  • Thalamus nucleus partitioning method based on global connection characteristics and geodesic distance
  • Thalamus nucleus partitioning method based on global connection characteristics and geodesic distance
  • Thalamus nucleus partitioning method based on global connection characteristics and geodesic distance

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Embodiment 1

[0041] Embodiment 1: see figure 1 , a method for partitioning thalamic nuclei based on global connectivity features and geodesic distance, the specific process is:

[0042] (1) Extract the labeled information and standard spatial coordinates of the whole brain voxels from the brain prior atlas, and then obtain the corresponding time series information of the whole brain voxels from the resting state magnetic resonance images of the brain. The brain tissue prior map used in this paper is the AAL (Automatic Anatomy Labeling) map. The AAL template defines a total of 116 regions, but only 90 belong to the brain, and the remaining 26 belong to the cerebellum structure. In order to reduce noise, this paper removes the cerebellum structure region . For example, the left thalamus is marked as 77 in the AAL template, and the voxel point marked 77 is found in the AAL template (x 1 , x 2 , x 3 ,...,x n ), then corresponding to the voxel point (x 1 , x 2 , x 3 ,...,x n ) correspo...

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Abstract

The invention discloses a thalamus nucleus partitioning method based on global connection characteristics and geodesic distance so as to realize brain thalamus area nucleus partitioning. The method comprises the following steps that: firstly, utilizing the time sequence information of a brain resting state magnetic resonance image, combining with the priori atlas of different tissues of the brainto construct the global connection characteristics of a thalamus voxel level, and lowering characteristic dimensions to reduce noise; then, combining with the three-dimensional space structure information of the brain, constructing a thalamus similarity matrix based on the geodesic distance, and more effectively utilizing the information of the characteristics; and finally, putting forward a normalization spectrum segmentation clustering method to combine with thalamus voxel similarity information to cluster the voxel. Compared with a traditional method, the method which is put forward by theinvention can more effectively lower the noise influence of the resting state magnetic resonance image, high-quality characteristics are extracted, and an accurate and effective thalamus nucleus partition is generated.

Description

technical field [0001] The invention relates to a method for partitioning thalamic nuclei, in particular to a method for partitioning thalamic nuclei based on global connection features and geodesic distances, and belongs to the technical field of digital images. Background technique [0002] The thalamus is the largest oval gray matter nucleus in the human diencephalon. In animals with underdeveloped cerebral cortex, the thalamus is the highest-level sensory center; in animals with developed cerebral cortex, it is the most important sensory transmission relay station, and all kinds of sensations (except smell) from the whole body can only be transmitted through the thalamus. to the cortical area. Dysregulation of the thalamus has been implicated in physiological and neurological disorders. At the cytoarchitectural level, the thalamus can be divided into several subregions, each with different connections to the cortex, so that different segmentations of the thalamus can d...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06K9/62
CPCG06V2201/03G06F18/23G06F18/22
Inventor 孔佑勇任洲甫吴飞沈傲东舒华忠
Owner SOUTHEAST UNIV
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