A method and a system for virtual design and evaluation of pharmaceutical formulation

A virtual design and pharmaceutical preparation technology, applied in design optimization/simulation, calculation, calculation model, etc., can solve the problems of long time-consuming cycle, high cost, low success rate of clinical trials, etc.

Inactive Publication Date: 2018-12-11
欧阳德方
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Problems solved by technology

The traditional drug prescription research work is mainly based on the personal experience of pharmaceutical R&D personnel to repeatedly screen prescriptions, evaluate and optimize process parameters in the laboratory or workshop through traditional trial-and-error...

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  • A method and a system for virtual design and evaluation of pharmaceutical formulation
  • A method and a system for virtual design and evaluation of pharmaceutical formulation
  • A method and a system for virtual design and evaluation of pharmaceutical formulation

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Embodiment Construction

[0063] Figure 1a and Figure 1b Draw the experimental research and development process of the existing pharmaceutical formulations ( Figure 1a ) and the virtual design and evaluation process of the pharmaceutical preparation prescription described in the present invention ( Figure 1b )Comparison. The research and development process of the existing pharmaceutical formulations has carried out a series of related experimental work from the pre-prescription research steps, mainly including literature search, determination of physical and chemical parameters of drugs and adjuvants, determination of basic pharmacokinetic parameters, and compatibility determination of drugs and adjuvants The four experimental parts will lay the foundation for the next drug prescription experiment and optimization steps. Drug prescription experiment and optimization steps, as the core technical part of drug prescription research and development, are mainly carried out from four aspects: dosage fo...

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Abstract

A method and a system for virtual design and evaluation of pharmaceutical formulation are provided. The invention discloses the method and the system for virtual design and evaluation of pharmaceutical preparation prescriptions, and the system mainly comprises a pre-prescription research module, a pharmaceutical prescription design and optimization module, a pharmaceutical preparation process design and optimization module, and a pharmaceutical prescription in-vivo prediction and evaluation module. The method and the system for virtual design and evaluation of pharmaceutical formulation predict the whole process of pharmaceutical formulation from four aspects of pharmaceutical pre-formulation research, formulation design, preparation process design and pharmacokinetics prediction in vivo.Compare with a conventional empirical drug prescription screening and preparation method in a traditional laboratory, the method and the system can accelerate the development of drug product, do not consume any laboratory equipment, complete the virtual design and evaluation of drug formulation prescription through a computer platform, shorten the drug development cycle and save the development cost of new drugs.

Description

technical field [0001] The present invention generally relates to a method and a system for applying mass modeling to the product development process of pharmaceutical compositions, and in particular to a method and system for virtual design and evaluation of pharmaceutical preparation prescriptions. Background technique [0002] Pharmaceutical formulation research is a comprehensive, multidisciplinary, complex research and exploration process, and its main steps can be briefly summarized as research work before drug formulation design, drug formulation design, and then research on formulation production process and drug formulation in vivo pharmacokinetics. Academic assessment, such a spiraling, step-by-step exploration process. [0003] Pre-prescription research of pharmaceutical preparations refers to the understanding, analysis, utilization or improvement of a series of basic physical properties, chemical properties and preparation properties of drugs before the formulat...

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Application Information

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IPC IPC(8): G06F17/50G06N99/00
CPCG06F30/20
Inventor 欧阳德方赵倩倩
Owner 欧阳德方
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