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Device and method for targeted ablation of cells, medium and electronic device

A targeting and cellular technology, applied in medical science, surgery, parts of surgical instruments, etc., can solve the problem that tumor-resistant cells or stem cells cannot be completely ablated.

Inactive Publication Date: 2019-01-11
HANGZHOU WKNIFE MEDICAL TECH CO LTD
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  • Abstract
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Problems solved by technology

[0005] The purpose of the embodiments of the present invention is to provide a device, method, medium, and electronic device for targeted ablation of cells based on pulsed electric fields, so as to overcome the inability to completely ablate tumor-resistant cells or stem cells in the prior art at least to a certain extent. multiple questions

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  • Device and method for targeted ablation of cells, medium and electronic device
  • Device and method for targeted ablation of cells, medium and electronic device
  • Device and method for targeted ablation of cells, medium and electronic device

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Embodiment Construction

[0091] Example embodiments will now be described more fully with reference to the accompanying drawings. Example embodiments may, however, be embodied in many forms and should not be construed as limited to the examples set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete and fully convey the concept of example embodiments to those skilled in the art.

[0092] Furthermore, the described features, structures, or characteristics may be combined in any suitable manner in one or more embodiments. In the following description, numerous specific details are provided in order to give a thorough understanding of embodiments of the invention. However, those skilled in the art will appreciate that the technical solutions of the present invention may be practiced without one or more of the specific details, or other methods, components, means, steps, etc. may be employed. In other instances, well-known methods, apparatus, implem...

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Abstract

The embodiment of the invention provides a device and method for targeted ablation of cells, based on a pulsed electric field, a medium and an electronic device. The method includes the steps: generating a high-voltage electric pulse targeting the ablation target cells; applying a high voltage electric pulse to a target cell, wherein a waveform of the high voltage electric pulse and an electric field intensity generated by the high voltage electric pulse are configured according to a component structure parameter and a dielectric parameter of the target cell. The technical proposal of the embodiments of the present invention can repeatedly generate high-voltage electric pulses targeting on tumor stem cells to induce their pyrogenation, and is applied to the tumor stem cells and the escapedhigh-malignancy tumor cells by irreversible electroporation ablation through electrodes and induce their pyrogenation.

Description

technical field [0001] The present invention relates to the technical field of tumor tissue ablation, in particular to a device, method, medium and electronic equipment for targeted ablation of cells based on pulsed electric fields. Background technique [0002] In the current tumor treatment, whether it is traditional radiotherapy, chemotherapy, or emerging treatment technologies such as hyperthermia, molecular immunotherapy, etc., clinically there are dose-limiting toxic DLT, biological resistance or escape, and off-target effects that cause residual tumors and tumor cell resistance. And immune system damage, etc., can lead to medical problems such as poor prognosis of patients, tumor recurrence and tumor metastasis. Under the severe situation of rising tumor morbidity and mortality in our country, for malignant tumors with high recurrence and high metastasis, how to overcome the resistance and variability of tumor cells and effectively inhibit recurrence and metastasis af...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/00
CPCA61B18/00A61B2018/0072A61B2018/00696
Inventor 姚陈果董守龙刘红梅赵亚军吕彦鹏马剑豪廖瑞金
Owner HANGZHOU WKNIFE MEDICAL TECH CO LTD
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