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Preparation methods and applications of Daphne feddei extract and pharmaceutical composition of Daphne feddei extract

An extract and yantuo technology, which is applied in the fields of traditional Chinese medicine and natural medicine pharmacy, can solve the problems such as the preparation method of yantuo extract, which has not been seen before, and achieve the effect of good anti-malarial activity.

Inactive Publication Date: 2019-02-15
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no reports on the preparation method of Yantuo extract, the drug combination with the extract as the active ingredient, and its application in antimalarial at home and abroad.

Method used

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  • Preparation methods and applications of Daphne feddei extract and pharmaceutical composition of Daphne feddei extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of rock tuo extract of the present invention:

[0019] Dry the whole plant of Yantuo plant naturally, crush it to 30 mesh, and use 5% ethanol at 95 o Under the condition of C, reflux extraction was carried out 3 times, each time for 2 h, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain the extract.

Embodiment 2

[0021] Antimalarial activity detection of the extract of the present invention:

[0022] Using the internationally accepted 4-day inhibition test method, each mouse was inoculated intraperitoneally with 1×10 7 Plasmodium-infected red blood cells were given intragastric administration 3 hours after inoculation with Plasmodium, and then administered once every 24 hours for 4 consecutive days (the inoculation day was D 0 , the next day is D 1 , and so on), on day 5 (D 4 ) blood from the tail vein, coated with a thin blood film, fixed in methanol, stained with Wright-Giemsa mixed staining method, and observed under a 10×100 oil microscope. If no Plasmodium asexual body is found after randomly checking 50 fields of view, it is judged as negative, and the positive thin blood film is randomly counted in 5 fields of view, and the total number of red blood cells is not less than 1000, and then the inhibition rate of Plasmodium is calculated according to the following formula .

[0...

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Abstract

The invention relates to an application of Daphne feddei extract to preparation of anti-malaria products, belongs to the field of pharmaceuticals of traditional Chinese medicine and natural drugs andprovides an anti-malaria drug containing the extract as an active component. Indications of Daphne feddei medicinal materials are broadened, and medicinal value of the traditional Daphne feddei medicinal materials is increased.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a preparation method of Yantuo extract, a drug combination with the extract as an active ingredient, and its application in antimalarial agents. technical background: [0002] Yan Tuo ( Daphne feddei Levl.) is Thymelaeaceae (Thymelaeaceae) Daphne genus ( Daphne ) plants, evergreen erect shrubs, 0.6-2 meters high; produced in Sichuan, Guizhou, Yunnan and other provinces; born in sparse forests or shrubs at an altitude of 1800-2600 meters. The bark fibers have strong toughness and can be used as raw materials for papermaking; flowers can be used to extract aromatic oil extracts. The whole plant or root of Yantuo is used as medicine. It tastes pungent, astringent, warm in nature, and slightly poisonous; At present, there are only a small amount of research reports on the chemical components of Yantuo and their anti-inflammat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61P33/06
CPCA61K36/83A61K2236/333A61K2236/35A61P33/06Y02A50/30
Inventor 姜北肖朝江陈浩崔淑君沈怡王敏董相
Owner DALI UNIV
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