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Preparation method and antimalarial application of Roscoea purpurea extract and pharmaceutical composition thereof

An extract and ivory technology, which is applied in the fields of natural medicine pharmacy and traditional Chinese medicine, can solve problems such as no ivory ginseng extract, and achieve the effect of good anti-malarial activity

Inactive Publication Date: 2021-03-12
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the preparation method of ginseng extract and the drug combination with the extract as the active ingredient, and its application in antimalarial at home and abroad

Method used

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  • Preparation method and antimalarial application of Roscoea purpurea extract and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of ivory ginseng extract of the present invention:

[0020] Take 100 g of the dried ginseng plant, crush it to 30 mesh, and use 75% ethanol at 95 o Under the condition of C, the extracts were refluxed three times, 2 hours each time, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain 17.1 g of extract, with an extraction rate of 17.1%.

Embodiment 2

[0022] Antimalarial activity detection of the extract of the present invention:

[0023] Using the internationally accepted 4-day inhibition test method, each mouse was inoculated intraperitoneally with 1×10 7 Plasmodium-infected red blood cells were given intragastric administration 3 hours after inoculation with Plasmodium, and then administered once every 24 hours for 4 consecutive days (the inoculation day was D 0 , the next day is D 1 , and so on), on day 5 (D 4 ) from the tail vein to collect blood, apply a thin blood film, fix with methanol, stain with Wright-Giemsa mixed staining method, and observe under a 10×100 oil microscope. If no Plasmodium asexual body is found after randomly checking 50 fields of view, it will be judged as negative, and if a positive thin blood film is randomly counted, 5 fields of view should be randomly counted, and the total number of red blood cells should not be less than 1000, and then the Plasmodium inhibition rate should be calculated...

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Abstract

The invention relates to a preparation method and antimalarial application of an Roscoea purpurea extract and a pharmaceutical composition thereof, and belongs to the field of traditional Chinese medicine and natural medicine pharmacy. The preparation method of the antimalarial drug taking the extract as the active ingredient comprises the following steps: taking dry whole plants or roots of Roscoea purpurea plants, crushing the Roscoea purpurea plants to 30 meshes, and performing extracting by using an organic solvent petroleum ether or chloroform or ethyl acetate or acetone or methanol or ethanol or water. According to the application of the Roscoea purpurea extract in preparation of the antimalarial agent, 0.01-30 g of the Roscoea purpurea extract is applied to a base material or a population, and is optionally combined with a carrier and / or a medium, so that the Roscoea purpurea extract has relatively good antimalarial activity. The invention develops the medicinal value of the ivory ginseng.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a preparation method of ginseng extract, a drug combination with the extract as an active ingredient, and its application in antimalarial agents. [0002] technical background: [0003] Ivory ginseng ( Roscoea purpurea Smith) is the genus Zingiberaceae (Zingiberaceae) ( Roscoe ) plant, perennial herb; plant height 15-45 cm; roots clustered, swollen and fusiform; stem base with 2 scale-like sheaths. Ivory ginseng is produced in Yunnan, and is also distributed in India, Sikkim and Myanmar; it grows under pine forests or in wild grass, at an altitude of 2700-3000 meters. According to "Chinese Materia Medica", ivory ginseng belongs to the closely related plant Yunnan ivory ginseng ( R. yunnanensis Loes.) and Tibetan Ivory Ginseng ( R. tibetica Bat.) have certain medicinal uses. Their roots are bitter in taste and cool in...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61P33/06
CPCA61K36/906A61K2236/33A61K2236/35A61K2236/39A61P33/06Y02A50/30
Inventor 姜北肖朝江郝艺刘蓉黄志莉刁红梅董相
Owner DALI UNIV
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