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Preparation method and antimalarial application of locust tree extract and pharmaceutical composition thereof

A technology of extract and locust tree, applied in the application of anti-malarial agent, the field of preparation of locust tree extract, to achieve the effect of good anti-malarial activity

Inactive Publication Date: 2021-03-02
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are no reports on the preparation method of pagoda tree extract, the drug combination with the extract as the active ingredient, and its application in antimalarial at home and abroad.

Method used

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  • Preparation method and antimalarial application of locust tree extract and pharmaceutical composition thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of pagoda tree extract of the present invention:

[0020] Take 118 g of the dry plant aerial part of Sophora japonica, crush it to 30 mesh, and use 75% ethanol at 95 o Under the condition of C, reflux extracted 3 times, each time for 2 hours, the extracts were combined, and the extracts were concentrated under reduced pressure to obtain 28.1 g of extract, with an extraction rate of 23.8%.

Embodiment 2

[0022] Antimalarial activity detection of the extract of the present invention:

[0023] Using the internationally accepted 4-day inhibition test method, each mouse was inoculated intraperitoneally with 1×10 7 Plasmodium-infected red blood cells were given intragastric administration 3 hours after inoculation with Plasmodium, and then administered once every 24 hours for 4 consecutive days (the inoculation day was D 0 , the next day is D 1 , and so on), on day 5 (D 4 ) blood from the tail vein, coated with a thin blood film, fixed in methanol, stained with Wright-Giemsa mixed staining method, and observed under a 10×100 oil microscope. If no Plasmodium asexual body is found after randomly checking 50 fields of view, it is judged as negative, and the positive thin blood film is randomly counted in 5 fields of view, and the total number of red blood cells is not less than 1000, and then the inhibition rate of Plasmodium is calculated according to the following formula .

[0...

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Abstract

The invention relates to a locust tree extract and a preparation method and application of a pharmaceutical composition thereof and belongs to the field of traditional Chinese medicine and natural medicine pharmacy. The preparation method of the anti-malaria medicine taking the extract as the active ingredient comprises the following steps of taking dry overground parts or whole plants of sophorajaponica plants, crushing to 30 meshes, and extracting by using an organic solvent petroleum ether or chloroform or ethyl acetate or acetone or methanol or ethanol or water. According to the application of the locust tree extract in preparation of the antimalarial agent, 0.01-30 g of locust tree extract is applied to a base material or a population, is optionally combined with a carrier and / or a medium, and has good antimalarial activity. According to the preparation method, indications of the sophora japonica medicinal material are expanded, and a medicinal value of the traditional sophora japonica medicinal material is improved.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine and natural medicine pharmacy, and in particular relates to a preparation method of a pagoda tree extract, a drug combination with the extract as an active ingredient, and its application in antimalarial agents. [0002] technical background: [0003] locust tree ( Sophora japonica L.) is the leguminosae (Leguminosae) Sophora genus ( Sophora ) plants, deciduous trees, up to 25 meters; native to China, now widely cultivated in northern and southern provinces, especially in North China and the Loess Plateau. According to "Chinese Pharmacopoeia", "Chinese Materia Medica" and other records, the whole body of locust tree is a treasure, and its branches, leaves, roots, flowers and fruits can be used as medicine; Drainage, red and white vaginal discharge, hemorrhoids, wet itching of the scrotum, heartache, red eyes, scabies, etc.; the leaves have the effects of clearing the liver and purgi...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P33/06
CPCA61K36/489A61K2236/333A61K2236/35A61K2236/39A61P33/06Y02A50/30
Inventor 姜北肖朝江张伟郝艺刘蓉刁红梅董相
Owner DALI UNIV
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