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Hair-related gene locus library and application method thereof

A gene locus, gene technology, applied in the field of genetic testing

Inactive Publication Date: 2019-02-19
江颖纯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on which genes affect the hair condition, and there is no related research on the judgment of hair problems through genetic testing, and the "customized hair" shampoo, hair care and hair care products have not been truly realized. , scientific maintenance of hair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] A total of 5 users provided gene detection reports (no other information was provided), their genes were compared with the gene locus library provided by the present invention, and the scores were calculated. The results are:

[0104] User 1: The polymorphic site rs523349 of the SRD5A2 gene is CC, rs1691053 is AA, rs700519 is TT, and the score of the SRD5A2 gene is 99 points; 2-The polymorphic site rs1799941 of the V89L gene is AA, rs6259 is AA, 2 -The score of the V89L gene is 100 points; the polymorphism site rs722208 of the AR gene is AA, rs1204038 is CC, and the score of the AR gene is 100 points; the polymorphism site rs1691053 of the DHT gene is GG, rs9287638 is AA, DHT The score of the gene is 100 points; the polymorphism site rs2981582 of the FGF-5 gene is TT, rs13317 is CC, and the score of the FGF-5 gene is 100 points. The expression of other genes is normal, so it can be inferred that the user has the problem of easy hair loss, and belongs to hormone-type hai...

Embodiment 2

[0111] A total of 3 users provided gene detection reports (no other information was provided), their genes were compared with the gene locus library provided by the present invention, and the scores were calculated. The results are:

[0112] User 1: The polymorphic site rs523349 of the SRD5A2 gene is CC, rs1691053 is AA, rs700519 is TT, and the score of the SRD5A2 gene is 99 points; the polymorphic site rs722208 of the AR gene is AA, rs1204038 is CC, and the score of the AR gene is The score is 100 points; the polymorphism site rs2981582 of FGF-5 gene is TT, rs13317 is CC, and the score of FGF-5 gene is 100 points; the polymorphism site of MAPK gene is TT rs13317, rs12701937 is CC, rs56234898 is AA, and the score of MAPK gene is 150 points, indicating vigorous lipid metabolism; the polymorphism site rs11549465 of HIF gene is CC, rs2057482 is CC, and the score of HIF gene is 100 points, indicating vigorous lipid metabolism; BCMO1 gene The polymorphic site rs7501331 is CC, rs119...

Embodiment 3

[0116]Use high-throughput sequencing technology to obtain the user's gene, then compare it with the gene locus library provided by the present invention, and calculate the score, the result is:

[0117] The polymorphic site rs2229569 of the SELL gene is GG, rs4987310 is GG, and the score of the SELL gene is 50 points; the polymorphic site rs747650 of the DDB2 gene is GG, and rs7531806 is AA, and the score of the DDB2 gene is 50 points; IL- The polymorphic site rs1474347 of the 6 genes is TT, rs1548216 is GG, rs1800795 is GG, the score of IL-6 gene is 60 points; the polymorphic site rs1800629 of TNF-alpha gene is AA, rs361525 is GG, TNF- The alpha gene has a score of 40 points. The expression of other genes is normal, so it is inferred that the user has folliculitis accompanied by dandruff. In line with the real situation of the user, it is recommended to use the inflammation care plan, which can improve the inflammation of the scalp and remove dandruff.

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Abstract

The invention belongs to the technical field of gene detection, and provides a hair-related gene locus library and an application method thereof. The gene locus library comprises SRD5A2 gene, 2-V89L gene, AR gene, DHT gene, FGF-5 gene, MAPK gene, HIF gene, BCMO 1 gene, SELL gene, DDB2 gene, IL-6 gene, TNF-alpha gene, Edar gene, VDR gene, CYP 450 gene, DAG gene, MCR1 gene, XRC1 gene, ERCC2 gene, KITLG gene, TYR gene, TYRP1 gene, OCA2 gene, Wnt gene and Beta-catenin gene. The locus library is comprehensive and reflects the root cause of hair problems from a gene level. Setting scores of polymorphic loci can simply evaluate the hair state, the evaluation result is accurate, and a scheme for personalized hair care is provided.

Description

technical field [0001] The invention belongs to the technical field of gene detection, and in particular relates to a hair-related gene locus library and its application. Background technique [0002] Today, many people choose skin care products based on their skin type or skin concerns, but few of them apply the same philosophy when it comes to hair care. It has almost become a common problem for the public to buy whichever product is strong in advertising and promotion. In fact, according to different hair quality needs, precise "symptomatic" care is required. Whether we are men or women, we all spend a lot of time taking care of our hair, yet some of us have beautiful black hair, while others have thinning, dry hair and various hair problems. Poor hair condition is caused by many factors, including genetic factors, human hormone levels and health status. Therefore, even if the symptoms of hair condition are consistent, it is very likely to be caused by different factor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888C12N15/11
CPCC12Q1/6888C12Q2600/156
Inventor 江颖纯黎璐
Owner 江颖纯
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