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Molecule detection device

A molecular detection and molecular technology, which is applied in the field of molecular carriers, can solve the problems of sample structure damage and cumbersome detection methods, and achieve the effect of increasing the enhancement factor and enhancing Raman scattering

Active Publication Date: 2019-03-15
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the process of extracting samples may cause damage to the sample structure, and the process of extracting samples also makes the detection method cumbersome

Method used

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  • Molecule detection device
  • Molecule detection device
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Embodiment Construction

[0031] The present invention will be further described in detail below in conjunction with specific embodiments and drawings.

[0032] Please refer to Figure 1 to Figure 2 The first embodiment of the present invention provides a molecular carrier 10 for molecular detection. The molecular carrier 10 includes a substrate 11, an intermediate layer 12, and a metal layer 13. Specifically, the intermediate layer 12 is arranged on the surface of the substrate 11, and the metal layer 13 is arranged on the surface of the intermediate layer 12. The intermediate layer 12 includes a substrate 121 and a plurality of patterned protrusions 122 disposed on the substrate 121, and the patterned protrusions 122 are disposed on the surface of the substrate 121 away from the base 11. The patterned protrusion 122 may include a plurality of protruding strips intersecting to form a mesh structure, thereby defining a plurality of holes 124. The intersection of the plurality of convex strips is an integ...

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Abstract

The invention relates to a molecule detection device. The device comprises a molecule carrier, a detector and a control computer, wherein the molecule carrier comprises a substrate, an intermediate layer and a metal layer; the intermediate layer is arranged between the substrate and the metal layer; the detector is used for detecting the molecules of the object to be detected on the surface of themolecule carrier; the control computer is connected to the detector and is used for analyzing the detecting result; the substrate is a flexible substrate; the intermediate layer comprises a substrateplate, and a plurality of patterned bumps which are arranged on the substrate; and the metal layer is arranged on the surfaces of the patterned bumps.

Description

Technical field [0001] The invention relates to a molecular carrier for molecular detection, a preparation method thereof, a method for detecting molecules using the carrier, and a molecular detection device. Background technique [0002] Single Molecule Detection (SMD) technology is an ultra-sensitive detection technology that can detect single molecules in chemical analysis, DNA sequencing, nanomaterial analysis, medical diagnosis, molecular dynamics mechanism, food safety and other fields Wide range of applications. Compared with traditional analysis methods, the single-molecule detection method studies the individual behavior of the system in a non-equilibrium state, or the fluctuation behavior in a balanced state, so it is particularly suitable for studying the kinetics of chemical and biochemical reactions, the interaction of biomolecules, and the structure and Functional information, early diagnosis of major diseases, pathological research, high-throughput drug screening,...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 王营城金元浩李群庆范守善
Owner TSINGHUA UNIV
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