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Solid oral pharmaceutical composition containing pimavanserin and preparation method for solid oral pharmaceutical composition

A technology of pimavanserin and its composition, which is applied in the field of pharmaceutical preparations, can solve the problems of high cost and complex process, and achieve the effects of simple prescription, mature process and improved drug compliance

Inactive Publication Date: 2019-03-22
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Commonly used preparation techniques for orally disintegrating tablets include freeze-drying, spray-drying, solid solution, and direct tableting techniques. The first three techniques are mature, but costly, complicated, and require special equipment. Due to the simplicity of the direct tableting process, At present, most domestically adopt the previous tablet compression process to prepare orally disintegrating tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Prescription composition:

[0029] .

[0030] Preparation Process:

[0031] (1) Take pimavanserin and pass through a 100-mesh sieve, and set aside;

[0032] (2) Weigh the raw materials and auxiliary materials of the prescription amount and mix them evenly in a small three-position mixer;

[0033] (3) Determine the drug content of the mixture and calculate the tablet weight;

[0034] (4) Direct compression.

Embodiment 2

[0036] Prescription composition:

[0037] .

[0038] Preparation Process:

[0039] (1) Take pimavanserin and pass through a 100-mesh sieve, and set aside;

[0040] (2) Weigh the raw materials and auxiliary materials of the prescription amount and mix them evenly in a small three-position mixer;

[0041] (3) Determine the drug content of the mixture and calculate the tablet weight;

[0042] (4) Direct compression.

Embodiment 3

[0044] Prescription composition:

[0045] .

[0046] Preparation Process:

[0047] (1) Take pimavanserin and pass through a 100-mesh sieve, and set aside;

[0048] (2) Weigh the raw materials and auxiliary materials of the prescription amount and mix them evenly in a small three-position mixer;

[0049] (3) Determine the drug content of the mixture and calculate the tablet weight;

[0050] (4) Direct compression.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing pimavanserin and a preparation method for the pharmaceutical composition. According to the composition suitable for preparing the orally disintegrating tablet, active ingredients are contained, a disintegrating agent and a diluent are also contained, in addition, a proper amount of a flavoring agent, a lubricant and a flow aid can also be contained. The composition has the advantages of being simple in prescription and mature in process, and only common tablet production equipment is adopted. The pharmaceutical composition can berapidly disintegrated within 30 s in an oral cavity and is not required to be taken with water, the medication compliance of Parkinson's disease is improved, and the economic loss caused by drug discarding by a patient can be avoided.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing pimavanserin oral solid preparation and a preparation method thereof. Background technique [0002] At present, there are about 7 million to 10 million Parkinson's disease patients in the world, and China has 2.6 million people, ranking first in the world, and there will be an increase of 100,000 new patients every year. More than 50% of patients with Parkinson's disease have had psychotic symptoms (PDP). These psychiatric symptoms mainly manifest as hallucinations and delusions, which bring greater challenges to the treatment and care of patients with Parkinson's disease. Dopamine is the main target of Parkinson's disease treatment. Since most antipsychotic drugs block dopamine in the brain and lead to worsening of motor dysfunction in Parkinson's patients, they are currently not suitable for such patients. [0003] T...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4468A61P25/16
CPCA61K9/0056A61K9/2018A61K9/2027A61K9/2054A61K9/2095A61K31/4468
Inventor 李春王宇杰马莉
Owner BEIJING VENTUREPHARM BIOTECH
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