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Immunoglobin IgY plural gelata for gynecological inflammation

A technology for gel and gynecological diseases, applied in the field of biomedicine, can solve the problems such as no treatment of Gardnerella vaginitis, and achieve the effects of no drug resistance, reduced recurrence rate and good therapeutic effect

Inactive Publication Date: 2019-04-12
江苏润洁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are currently no medications that can treat Gardnerella vaginitis and prevent recurrence

Method used

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  • Immunoglobin IgY plural gelata for gynecological inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Anti-Gynecological Inflammation Pathogen Specific Composite IgY Antibody

[0042] 1. Antigen preparation

[0043] Candida albicans and Gardnerella were ingested from patients with vaginitis and cultured by conventional methods.

[0044] The prepared Candida albicans and Gardnerella were mixed in a ratio of 1:1 and pulverized by conventional methods, and placed in a "tissue masher homogenizer" at 8000-12000rpm to fully mash and stir evenly. Then add this mixture to Freund's adjuvant in a ratio of 1-10:1-10 (usually 1:1), put it into a high-speed homogenizer and homogenize at a high speed of 30,000rpm to form a water-in-oil emulsion, that is, to obtain a composite antigen.

[0045] 2. Antibody preparation

[0046] 1) Immunity:

[0047] The selected laying hens with high immune response ability are injected with the compound antigen prepared in step ① by using the immune activation method. At an interval of 7 days after the first injection, inject the second...

Embodiment 2

[0063] Example 2 Composition 1 for treating gynecological inflammation and the prepared composite yolk antibody gel

[0064] 50g of the composite egg yolk antibody obtained in Example 1, 200ml of 1000ppm nano-silver water-soluble dispersion, 400ml of glycerin, and 1500ml of water; after mixing, adjust the pH value to 5.5±0.1, and homogenate to obtain a gel.

Embodiment 3

[0065] Example 3 Composition 2 for treating gynecological inflammation and the prepared composite yolk antibody gel

[0066] 80g of the composite yolk antibody obtained in Example 1, 300ml of 1000ppm nano-silver water-soluble dispersion, 500ml of glycerin, and 1500ml of water; after mixing, adjust the pH value to 5.5±0.1, homogenate to obtain a gel.

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PUM

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Abstract

The invention belongs to the field of biomedical science, and particularly relates to plural gelata for gynecological inflammation. The gelata contains a complex yolk antibody and nanosilver, whereinthe complex yolk antibody is obtained by using gardnerella and candida albicans as antigens for direct immunization of laying hens. The yolk antibody can be used for preparing medicines for treating gynecological inflammation of vagina infection, and a high activity antibody is input into vaginas for patients suffering from gynecological inflammation. The nanosilver is combined. The yolk antibodyand the prepared plural gelata for treating gynecological inflammation, disclosed by the invention, have important significance in curing gynecological diseases caused by vagina infection.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an immunoglobulin compound gel for gynecological inflammation. Background technique [0002] Bacterial vaginosis (BV) can increase the risk of pelvic inflammatory disease in women, increase the susceptibility to sexually transmitted diseases, and lead to adverse pregnancy and other consequences. Gardnerella vaginalis (GV) is one of the important pathogens of bacterial vaginosis. Gardnerella vaginitis is a type of bacterial vaginosis, also known as Haemophilus vaginitis, is a vaginal mucosal inflammation caused by Gardnerella, which can be transmitted through sexual intercourse. [0003] Gardnerella are small, Gram-negative bacilli, often club-shaped, sometimes filamentous and polymorphic, and bipolar staining is common. 0.4--0.6 microns wide, 1--2 microns long, inactive, flagella-free, and spore-free. Many strains have capsules. In artificial cultivation, fresh blood mu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K9/06A61K47/10A61P15/00A61P15/02A61P17/04A61P31/02A61P31/04A61P31/10A61P33/02A61K33/38
CPCA61K9/0034A61K9/06A61K33/38A61K39/40A61K47/10A61P15/00A61P15/02A61P17/04A61P31/02A61P31/04A61P31/10A61P33/02A61K2300/00
Inventor 庞以芹吴必杰魏勇
Owner 江苏润洁生物科技有限公司
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