Application of ASMT/CYP1A1 molecular tag in predicting clinical prognosis or immune characteristics of solid tumors

A technology of CYP1A1 and entities, which is applied in the field of application of ASMT/CYP1A1 molecular tags in predicting the clinical prognosis or immune characteristics of solid tumors, can solve the problems of no molecular tags, etc., and achieve the effect of improving the therapeutic effect

Active Publication Date: 2019-04-19
SUN YAT SEN UNIV CANCER CENT
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  • Abstract
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Problems solved by technology

However, there are currently no molecular tags for relevant applications

Method used

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  • Application of ASMT/CYP1A1 molecular tag in predicting clinical prognosis or immune characteristics of solid tumors
  • Application of ASMT/CYP1A1 molecular tag in predicting clinical prognosis or immune characteristics of solid tumors
  • Application of ASMT/CYP1A1 molecular tag in predicting clinical prognosis or immune characteristics of solid tumors

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with specific experiments. It should be understood that the following content is only used to illustrate the present invention and is not intended to limit the protection scope of the present invention.

[0022] ASMT / CYP1A1 ratio in different solid tumors

[0023] By analyzing 14 solid tumors (bladder cancer, breast cancer, cervical cancer, colon cancer, head and neck squamous cell carcinoma, kidney cancer, hepatocellular carcinoma, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, prostate cancer, skin cancer) in the public database TCGA , gastric cancer and thyroid cancer) transcriptome and genome data of 6,658 tumor samples, and calculate the ratio of ASMT to CYP1A1 in each tumor tissue (ASMT / CYP1A1), which reflects the level of melatonin in the tumor tissue. The ASMT / CYP1A1 results of each tumor tissue were divided into High Index and Low Index ( figure 1 )Group.

[0024] Rela...

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Abstract

The invention discloses an application of an ASMT/CYP1A1 molecular tag in predicting clinical prognosis or immune characteristics of solid tumors. By studying the transcription group and genome data of 6658 tumor samples of 14 solid tumors and carrying out biological information analysis of large samples, the relationships between the ASMT/CYP1A1 ratio levels in different solid tumors and the clinical prognosis, tumor mutation level of and tumor neogenesis antigen load of patients are confirmed, wherein the clinical prognosis of patients with cervical cancer, gastric cancer and melanin in theHigh Index group is more considerable. The results of multivariate analysis show that the results of ASMT/CYP1A1 are independent prognostic indexes for the clinical prognosis of patients with tumors.In addition, in patients with colorectal cancer, head and neck squamous cell carcinoma, renal cancer, liver cancer, prostate cancer and melanoma, the prognosis of the LowIndex group is poor, but moremutation load and/or tumor neogenesis antigen exist in the LowIndex group, suggesting that the patients in the LowIndex group are more likely to benefit from immunotherapy.

Description

technical field [0001] The present invention relates to markers and applications for predicting clinical prognosis of solid tumors, immune body mutation level and / or neoantigen load. Background technique [0002] Tumor is the third major disease threatening human health. In 2018, there were about 18.19 million new cancer cases and 9.6 million cancer deaths worldwide. The incidence of tumors has shown a downward trend year by year with the advancement of medical technology and the enhancement of people's awareness of cancer prevention, while the mortality rate of some cancers is still high. Therefore, it is very important to accurately evaluate the prognosis of tumor patients and choose the appropriate treatment plan according to their characteristics. In recent years, immunotherapy has developed rapidly and has become the fourth major anti-cancer weapon after surgery, radiotherapy and chemotherapy, and targeted therapy. Relevant immunotherapy drugs, such as anti-PD-1 mono...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 孙颖吕佳蔚陈雨沛郑子奇
Owner SUN YAT SEN UNIV CANCER CENT
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