Methods for classifying patients with a solid cancer

A cancer and patient technology, applied in the field of patient responsiveness to anti-tumor therapy, can solve problems such as unpredictable response to therapy, and achieve the effect of prolonging survival

Active Publication Date: 2019-04-26
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS +3
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current classification provides limited prognostic information and does not predict response to treatment

Method used

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  • Methods for classifying patients with a solid cancer
  • Methods for classifying patients with a solid cancer
  • Methods for classifying patients with a solid cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0212] A reference group of patients (n=539) with stage I / II / III colorectal cancer was analyzed according to the algorithm scoring method. Whole slide tumors were stained with CD3 antibody and CD8 antibody. Using digital pathology and image analysis software, determine the invasive margin (IM) of the tumor and the core (center) of the tumor (CT). Quantification of CD3 and CD8 densities in CT and IM regions (cells / mm 2 ). Distributions of all densities or all markers were plotted and reported in the table. The corresponding percentiles are derived (i.e. at 5% step intervals). In the example shown in the table below, the average of 4 density biomarker values ​​was calculated, each biomarker being weighted by 1. The Kaplan-Meier curves for this cohort are shown in image 3 Above, the 5 groups of categories (I0, I1, I2, I3, I4) correspond to the average percentile value.

[0213] In the table below is an illustration of an example of calculating the arithmetic mean of the p...

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Abstract

The present invention relates to methods for classifying patients suffering from a solid cancer, particularly to methods for the prognosis of the survival time of a patient suffering from a solid cancer and / or to methods for assessing the responsiveness of a patient suffering from a solid cancer to antitumoral treatment. The method is based on quantifying multiple immune response markers and determining to which percentile of the distribution the values correspond when compared to a reference distribution. Calculating the mean or median of the determined percentiles of the different markers and comparing this value to a reference value of the mean- or median percentiles, the result of which is correlated with survival or responsiveness

Description

technical field [0001] The present invention relates to methods for classifying patients with solid cancers, in particular to methods for prognosing the survival time of patients with solid cancers and / or for assessing the responsiveness of patients with solid cancers to anti-tumor therapy Methods. Background technique [0002] As explained in detail by Galon et al. (Cancer classification using the Immunoscore: a worldwide task force, J Transl Med. 2012; 10:205), predicting clinical outcomes in cancer is often This was achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC / UICC-TNM classification) pools data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N), and evidence of metastasis (M). However, it is now recognized that clinical outcomes can vary significantly between patients within the same stage. The current classification provides limit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCC12Q1/6886G01N33/574G01N33/57419G01N33/57484G16H50/20G16H50/30C12Q2600/158C12Q2600/118G01N2800/50G01N2800/52G01N2800/60C12Q1/6851C12Q1/6862
Inventor 热罗姆·加隆贝恩哈德·米雷克尼克弗兰克·帕格斯
Owner ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
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