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Ercc1 and other markers for stratification of non-small cell lung cancer patients

A non-small cell lung cancer, patient technology, applied in biological testing, analytical materials, instruments, etc., can solve problems such as lack of survival

Inactive Publication Date: 2019-06-04
NANTOMICS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Indeed, it was previously hypothesized that low tumor expression or lack of tumor expression of ERCC1 protein could predict improved survival in platinum-treated NSCLC patients

Method used

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  • Ercc1 and other markers for stratification of non-small cell lung cancer patients
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  • Ercc1 and other markers for stratification of non-small cell lung cancer patients

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Embodiment

[0032] Clinical data and biomarker data from 150 patients in the TASTE trial (IFCT-0801TASTE) were received in excel format, saved in .txt format, and read into R language for data preprocessing and statistical analysis. Down figure 1 A flow chart detailing the patients available for the primary and secondary analyzes of ERCC1 association with recurrence-free survival (PFS) and overall survival (OS) and an exploratory analysis assessing the association between various biomarkers is shown picture. ERCC1 proteome data were obtained from FFPE biopsy samples subjected to laser microdissection to obtain tumor tissue and subsequently subjected to selected reaction monitoring mass spectrometry.

[0033] The input proteomic biomarker data were converted to numerical variables, where "ND" representing the non-detectable level of a given biomarker was taken as 0 and "NR" representing missing data was replaced with NA. Survival endpoints were defined according to the STEEP system. Ove...

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Abstract

Proteomics data are employed to predict treatment outcome for cisplatin / pemetrexed therapy of NSCLC. Notably, ERRC1 can be used as a binary marker where protein presence or absence is measured by massspectroscopy, and additional proteins may serve as further predictive markers, particularly for prediction of PFS.

Description

[0001] This application claims priority to U.S. Provisional Application Serial No. 62 / 311368, filed March 21, 2016, and also claims priority to U.S. Provisional Application Serial No. 62 / 337209, filed May 16, 2016; both provisional Both applications are incorporated herein by reference. technical field [0002] The field of the invention is systems and methods for correlating selected markers with clinical outcomes, particularly with regard to non-small cell lung cancer and ERCC1 status and recurrence-free survival / overall survival. Background technique [0003] The Background Description includes information useful in understanding the present invention. It is not an admission that any information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0004] All publications and patent applications are herein incorporated by reference as if each individual publication or pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/574G01N33/68G01N33/57423
Inventor 克里斯蒂娜·亚乌法比奥拉·切基托迪·亨布罗
Owner NANTOMICS LLC
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