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A Method for Synthesizing Anticancer Drugs/MOFs Composite Functional Materials by Pressure

A technology of anti-cancer drugs and compound functions, which is applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problem that anti-cancer drug molecules cannot be directly encapsulated, and achieve selective release, increased loading rate, and high loading rate effect

Active Publication Date: 2022-02-18
NANJING TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the size of anticancer drug molecules is generally at the nanometer level, but MOFs materials such as ZIF-8 have pores of Anticancer drug molecules cannot be directly encapsulated in ZIF-8

Method used

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  • A Method for Synthesizing Anticancer Drugs/MOFs Composite Functional Materials by Pressure
  • A Method for Synthesizing Anticancer Drugs/MOFs Composite Functional Materials by Pressure
  • A Method for Synthesizing Anticancer Drugs/MOFs Composite Functional Materials by Pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of MOFs materials (taking ZIF-8 as an example):

[0028] Weigh 2-methylimidazole (22.7g, 0.28mol) and dissolve it in 8ml of water (0.03mol mL-1). Weigh Zn(NO 3 ) 2 ·6H 2 O (1.17g, 3.9mmol), dissolved in 80ml of water (0.049mmol mL-1). Respectively ultrasonic solution from turbid to clear and transparent, Zn(NO 3 ) 2 ·6H 2 The O aqueous solution was poured into the 2-methylimidazole aqueous solution, and the solution instantly turned into a white milky substance, and stirred for 5 minutes at a speed of 600 rpm. Then the white emulsion was centrifuged with a centrifuge tube, ultrasonicated for several minutes, washed with water three times, and then activated in a vacuum oven at 120°C to obtain ZIF-8 with a size of 100nm dodecahedron. Preparation of anticancer drug / ZIF-8 composites:

[0029] Weigh 50mg of the activated ZIF-8 material and 50mg of the anticancer drug dobirubicin hydrochloride, mix them thoroughly, put 20mg of the mixture into the cavity ...

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Abstract

The invention discloses a method for synthesizing an anticancer drug / MOFs composite functional material through pressure, which comprises the following steps: after mixing MOFs and anticancer drug molecules, the self-combination of MOFs particles and anticancer drug molecules is obtained through axial pressure. Assembling the composite material; placing the above self-assembled composite material in a solvent or steam containing the solvent; raising the temperature of the above solvent or the steam containing the solvent to 25-50°C, holding time for 5-120h, and then post-processing , to obtain the anticancer drug / MOFs composite functional material. The anticancer drug has a high loading rate in the MOFs material, and the method is simple and easy to achieve selective release in the PBS buffer solution.

Description

technical field [0001] The invention relates to the field of multifunctional coordination polymer composite materials, in particular to a method for synthesizing anticancer drug / MOFs composite functional materials through pressure. Background technique [0002] Cancer has always been one of the important diseases threatening human health, and scientists and medical researchers from all over the world are working hard to overcome it. Cancer treatment methods currently mainly include surgery, radiotherapy and chemotherapy. Chemotherapy drugs generally have great cytotoxicity. The drugs are carried to the whole body through blood vessels, and have a great destructive effect on cancer cells and normal cells in the body, and the toxic and side effects are very obvious. Therefore, how to bring chemotherapy drugs to malignant tumor tissues to target and kill cancer cells without affecting normal cells, so as to improve the survival rate and quality of life of patients has become t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/22A61K31/704A61P35/00
Inventor 霍峰蔚任臻沈宇张伟娜张江维
Owner NANJING TECH UNIV