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Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating fat metabolism syndromes

1. The technology of mir-327 and inhibitors, which is applied in the field of medicine, can solve problems such as obesity and health hazards, and achieve the effects of improving energy consumption, promoting metabolism, and significantly preventing or treating effects

Active Publication Date: 2019-06-18
义慧科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the commercially available drugs for the treatment of obesity, most of them are based on methods such as emetic induction and appetite suppression to reduce the intake of energy in the body so as to achieve the goal of weight loss, but this will cause certain harm to health and cannot radically change obesity

Method used

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  • Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating fat metabolism syndromes
  • Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating fat metabolism syndromes
  • Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating fat metabolism syndromes

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Experimental program
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Embodiment 1

[0054] Embodiment 1 administers drugs to mice, and explores the influence of drugs on the weight and shape of adipose tissue

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Abstract

The invention provides novel application of an miR-327 inhibitor and / or an FGF10 accelerant, specifically application to preparation of a medicine for preventing and / or treating fat metabolism syndromes. The miR-327 inhibitor and the FGF10 accelerant both can promote addition of FGF10 in matrix cell compositions of adipose tissue, promote adipose cell precursor of the matrix cell compositions to differentiate to brown adipose cells, promote energy consumption and promote fat metabolism, so that the purpose of preventing and / or treating fat metabolism syndromes is achieved. The invention further provides the medicine for preventing and / or treating fat metabolism syndromes. The medicine comprises the miR-327 inhibitor and pharmaceutically acceptable carriers thereof.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of miR-327 inhibitors and / or FGF10 promoters in drugs for preventing and / or treating lipodystrophy. Background technique [0002] Fat metabolism is the process of digestion and absorption, synthesis and decomposition of fat in the body with the help of various related enzymes, and it is processed into the substances needed by the body to ensure the normal operation of physiological functions, which is of great significance to life activities. Diseases caused by abnormal fat metabolism are common diseases in modern society. Among them, obesity is a common fat metabolism disease, characterized by an increase in the volume and number of fat cells in the body leading to an abnormally high percentage of body fat in body weight and excessive fat deposition in some localities. According to statistics, 15%-20% of patients who die from diseases are accompanied by obesit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/18A61K31/7105A61P3/00
Inventor 杨云龙曹义海
Owner 义慧科技(深圳)有限公司
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