Chimeric antigen receptor using CD99 as target site and application of chimeric antigen receptor

A technology of antigen and receptor, applied in the field of medicine and biology, to achieve the effect of improving tumor killing efficiency and scientific evaluation of tumor killing effect
CN110590960AActive Publication Date: 2019-12-20WUHAN BIO RAID BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN BIO RAID BIOTECH CO LTD
Publication Date
2019-12-20

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Abstract

The present invention discloses a chimeric antigen receptor using a CD99 receptor as a target site and a use of the chimeric antigen receptor. A splice peptide, a single-chain antibody ScFv, strepII,CD8 hinge, a CD28 transmembrane region, a CD28 intracellular structural domain, an intracellular co-stimulatory domain 4-1BB and a CD3-zeta chain are sequentially spliced from a N-terminus to a C-terminus, and more preferably, the splice signal peptide, the single-chain antibody ScFv, the strepII, the CD8 hinge, the CD28 transmembrane region, the CD28 intracellular structural domain, the intracellular co-stimulatory domain 4-1BB, the CD3-zeta chain, a F2A peptide, IL-7, a F2A peptide and CCL19 are sequentially spliced from the N-terminus to the C-terminus. The single chain antibody ScFv can specifically recognize the CD99 receptor on surfaces of tumor cells. The chimeric antigen receptor using the CD99 receptor as the target site is used to modify immune cells and the modified immune cellscan be used for treatment of surface CD99-positive tumors.
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Description

technical field

[0001] The invention relates to the field of medicine and biology, in particular to a chimeric antigen receptor (CAR) targeting CD99 for treating broad-spectrum tumors and its application. Background technique

[0002] In early 2019, data released by the American Cancer Society showed that there were 18.1 million new cases of cancer and 9.6 million deaths worldwide in 2018. The incidence and death rate of cancer in the Chinese population ranked first in the world, and showed a rapid growth trend. Scientists around the world are also working on the research of various anticancer therapies. Immunotherapy, as the third revolution in anticancer therapy after chemotherapy and targeted therapy, has become a new generation of tumor treatment. In 2013, American "Science" magazine selected tumor immunotherapy as the biggest scientific breakthrough of the year, and in 2015, combined tumor immunotherapy was listed as one of the four most noteworthy scientific advances. ...

Claims

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