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A kind of preparation method of silymarin skin care product

A technology of silymarin and skin care products, which is applied in the field of preparation of silymarin skin care products, can solve problems such as uneven distribution of silymarin, easy clogging of skin pores, and instability, and achieve the effects of avoiding clogging of skin pores, easy absorption, and solving instability

Active Publication Date: 2022-05-03
ZHONGXING PHARM CO LTD JIANGSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Research data show that silymarin has anti-aging and anti-radiation effects in clinical practice. According to the above-mentioned efficacy characteristics of silymarin, many research institutes at home and abroad have actively carried out research on the use of silymarin in cosmetic and skin care products. Currently, through the water-oil wrapping technology of cosmetics Although it solves the technical requirement of non-layering of cosmetics in the container, due to the special nature of silymarin as a fat-soluble substance, the method of water and oil wrapping can only solve the separation of silymarin macromolecules, and cannot fundamentally change the fact that silymarin is not conducive to skin absorption. Features, the current silymarin skin care products have the following problems: (1) the distribution of silymarin in the cosmetic matrix is ​​uneven and unstable; (2) it is difficult to be absorbed by the skin, and it is easy to block the pores of the skin after long-term use

Method used

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  • A kind of preparation method of silymarin skin care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for preparing silymarin skin care products, the dosage formula of each substance is as follows:

[0029] Silymarin: 100 g

[0030] Meglumine: 20 g

[0031] Absolute ethanol: 300 g

[0032] Deionized water: 600 g

[0033] Gelatin: 240g

[0034] Glycerol: 600g

[0035] Sodium benzoate: 1.2 g;

[0036] The preparation method is as follows:

[0037] (1) Weigh 100g of silymarin and 20g of meglumine dissolved in 300g of absolute ethanol, slightly boiled for 40min;

[0038] (2) Recovery of anhydrous ethanol in silymarin glumethamine anhydrous ethanol solution:

[0039] A) Add silymarin meglumine solution to the rotary water bath membrane evaporator, rotate at 70 °C while heating, the speed is 60r / min, until the solution begins to reflux, open the vacuum, the vacuum degree is -0.06MPa, the ethanol is recovered, heating and selection are carried out at the same time;

[0040] B) Heat at 100 °C, and keep the rotation speed until the silymarin meglumine solution becomes an ex...

Embodiment 2

[0046] A method for preparing silymarin skin care products, the dosage formula of each substance is as follows:

[0047] Silymarin: 100 g

[0048] Meglumine: 30 g

[0049] Absolute ethanol: 520g

[0050] Deionized water: 1250 g

[0051] Gelatin: 400g

[0052] Glycerol: 1000 g

[0053] Sodium benzoate: 1 g;

[0054] The preparation process steps are as follows:

[0055] (1) Weigh 100g silymarin and 30g of meglumine dissolved in 520g of anhydrous ethanol, slightly boiled for 45min;

[0056] (2) Recovery of anhydrous ethanol in silymarin glumethamine anhydrous ethanol solution:

[0057] A) Add silymarin meglumine solution to the rotary water bath membrane evaporator, rotate at 80 °C while heating, the speed is 70r / min, until the solution begins to reflux, open the vacuum, the vacuum degree is -0.07MPa, the recovery of ethanol, heating and selection are carried out at the same time;

[0058] B) Heat at 100 °C, and keep the rotation speed until the silymarin meglumine solution becomes ...

Embodiment 3

[0064] A method for preparing silymarin skin care products, the dosage formula of each substance is as follows:

[0065] Silymarin: 100 g

[0066] Meglumine: 50 g

[0067] Ethanol absolutely: 750g

[0068] Deionized water: 1800 g

[0069] Gelatin: 450g

[0070] Glycerol: 1050g

[0071] Sodium benzoate: 0.45 g;

[0072] Process steps:

[0073] (1) Weigh 100g silymarin and 50g of meglumine dissolved in 750g of absolute ethanol, slightly boiling for 50min;

[0074] (2) Recovery of anhydrous ethanol in silymarin glumethamine anhydrous ethanol solution:

[0075] A) Add silymarin meglumine solution to the rotary water bath membrane evaporator, rotate at 100 °C while heating, the speed is 100r / min, until the solution begins to reflux, open the vacuum, the vacuum degree is -0.08MPa, the recovery of ethanol, heating and selection are carried out at the same time;

[0076] B) Heat at 100 °C, and keep the rotation speed until the silymarin meglumine solution becomes an extract, open the vacu...

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Abstract

The invention discloses a preparation method of a silymarin skin care product. The silymarin and meglumine are dissolved in absolute ethanol, and the absolute ethanol is recovered after heating to obtain a raw material of silymarin meglumine; then mixed with deionized water and placed Stir in a blender, finally add gelatin and glycerin and stir, then add sodium benzoate, and ultrasonically process to obtain the desired silymarin skin care product. The invention solves the shortcomings of the traditional skin care products that directly use silymarin to prepare related skin care products, resulting in excessive facial skin oil and clogged pores; and makes the silymarin meglumine and sodium benzoate uniform While being distributed in other matrices, silymarin meglumine will not be decomposed and destroyed.

Description

Technical field [0001] The present invention relates to the field of skin care preparation methods, in particular to a silymarin skin care preparation method. Background [0002] Research data show that silymarin in the clinic has anti-aging, anti-radiation effect, according to the above functional characteristics of silymarin, many research units at home and abroad have actively carried out the study of silymarin for makeup and skin care products, at present, through the cosmetics water oil wrapping technology although to solve the cosmetics in the container does not stratify the technical requirements, but because of the special nature of silymarin as a fat-soluble substance, the method of water oil wrapping can only solve the separation of silymarin macromolecules, Silymarin can not fundamentally change the characteristics of silymarin is not conducive to skin absorption, the current silymarin skin care products have the following problems: (1) silymarin in the cosmetic matri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/65A61K8/34A61K8/41A61K8/49A61Q17/04A61Q19/08
CPCA61K8/498A61K8/41A61K8/65A61K8/345A61Q19/08A61Q17/04A61K2800/82
Inventor 武俊明
Owner ZHONGXING PHARM CO LTD JIANGSU
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