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A kind of hyaluronic acid gel composition for hydrolight injection and preparation method thereof

A gel composition and a technology of hyaluronic acid, which are applied in the field of biomedicine, can solve the problems of short maintenance time of hyaluronic acid, unsuitable for water-light injection, accelerated onset time, etc., and achieve fast onset of moisturizing and moisturizing, and avoid complicated Process and cross-linking, the effect of avoiding toxic and side effects

Active Publication Date: 2021-09-17
BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the technical problem that the cross-linked hyaluronic acid gel in the prior art has a long degradation time, it is not suitable for water-light injection, and its effect is slow; the hyaluronic acid used for water-light injection maintains a short time in the body. The water-retaining time of hyaluronic acid injected by water-light needle injection and the onset time are accelerated. This application provides a hyaluronic acid gel composition for water-light injection, which has a longer degradation and absorption time and is more effective than existing hyaluronic acid. Long hydrating and moisturizing maintenance time and faster onset time, suitable for water light injection, impurities are less toxic, and will not produce bulging, so water light injection can be used to improve skin quality more effectively

Method used

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  • A kind of hyaluronic acid gel composition for hydrolight injection and preparation method thereof
  • A kind of hyaluronic acid gel composition for hydrolight injection and preparation method thereof
  • A kind of hyaluronic acid gel composition for hydrolight injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of disulfide bond cross-linked hyaluronic acid gel

[0048] Hyaluronic acid thiolated derivatives are prepared using sodium hyaluronate with a molecular weight of 180KDa as a raw material, and are prepared by the method reported by Shu et al. / g and 57μmol / g.

[0049] Dissolve the above-mentioned hyaluronic acid mercapto derivatives to obtain an aqueous solution with a content of 6 mg / mL or 12 mg / mL, adjust the pH of the solution to 7.4, transfer it into a sterile glass container after sterilizing and filtering; keep it airtight at room temperature for 4 weeks, and the solution Loss of fluidity and formation of disulfide cross-linked hydrogels.

Embodiment 2

[0050] Embodiment 2: the preparation of hyaluronic acid gel composition

[0051] Sodium hyaluronate (50KDa) was dissolved to obtain an aqueous solution with a content of 12 mg / mL, the pH value of the solution was adjusted to 7.4, and it was sterilized and filtered for use.

[0052] The disulfide cross-linked hyaluronic acid gel (12mg / mL) prepared in Example 1 and the above-mentioned hyaluronic acid aqueous solution were mixed according to the volume ratio of 1:11, 1:5, 1:3, 1:2, 1:1.4, 1:0.5, 1:0.3, 1:0.2 and 1:0.091 were physically stirred and mixed to obtain the hyaluronic acid gel composition with the ratio shown in the table below.

[0053]

Embodiment 3

[0054] Example 3: Injectable Performance Evaluation of Hyaluronic Acid Gel Composition

[0055] Using Derma (Demasa) 2nd generation water-light injection device, to test the injectability of the hyaluronic acid gel composition prepared in Example 2 through conventional water-light injection needles (nine needles). When the content of disulfide cross-linked hyaluronic acid in the hyaluronic acid gel composition is 1mg / mL, 2mg / mL, 3mg / mL and 4mg / mL, it has good injectability; and when the content is ≥5mg / mL When it is less than mL, it is difficult to inject through the water-light injector.

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Abstract

The invention discloses a hyaluronic acid gel composition for hydrolight injection, which contains 1) disulfide bond cross-linked hyaluronic acid, and the content of hyaluronic acid in the gel is not more than 10 mg / mL; and 2) Non-cross-linked hyaluronic acid. The hyaluronic acid gel composition of the present invention has a unique advantage when used in hydro-optic injection, it is easy to inject through the ultra-fine needle of a hydro-optical needle, and can achieve good uniform distribution in the subcutaneous superficial layer without bulging; it works Quick and long-lasting moisturizing effect, can effectively improve skin texture.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to a hyaluronic acid gel composition for hydro-optic injection, and a preparation method of the hyaluronic acid gel composition for hydro-optic injection. Background technique [0002] In recent years, the medical beauty industry at home and abroad has developed rapidly, and various emerging beauty technologies have been developed. Water light injection is one of the most extensive medical cosmetology projects at home and abroad. It can effectively solve the problem that skin care products used on the body surface are not easily absorbed through the epidermal barrier. senescence. Water-light injection originated from Mesotherapy proposed by French doctor Michal Pistor in 1952. Its concept is to inject a small amount of therapeutic substances in the local superficial surface; after decades of hard work, the current water-light injection technology was developed. Shuiguang injecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/04A61Q19/00C08J3/075C08L5/08
CPCA61K8/042A61K8/735A61K2800/91A61Q19/00C08J3/075C08J2305/08C08J2405/08
Inventor 王云云胡慕兰张红晨王坤王昕宇宋文俊舒晓正
Owner BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTD
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