Biphenyl compound-containing solid preparation and applications thereof

Abstract

The invention belongs to the field of acaricides, and relates to a biphenyl compound-containing solid preparation and applications thereof, wherein a compound A is used as an active component and is matched with at least a carrier and at least an auxiliary agent, the weight percentage content of the active component compound A of the solid preparation is 0.5-90%, the auxiliary agent contains a suspending aid, and the weight percentage content of the suspending aid is 0.01-5%. According to the invention, a proper auxiliary agent system condition is selected and matched, a suspending aid substance liquiritin is added into the solid preparation according to a specific ratio to effectively improve the suspension rate of the solid preparation, and the liquiritin and the structure of the compound A interact, so that the defects of softening and dissolving of solid particles are inhibited, the problems that low-melting-point raw medicine solid preparation particles are prone to melting and softening and low in suspension rate in the prior art are solved, the suspension rate of the solid preparation is qualified, the product performance is guaranteed, and the unexpected effect is achieved.

Description

technical field [0001] The invention belongs to the field of acaricides, and relates to a solid preparation containing biphenyl compounds and an application thereof. Background technique [0002] The biphenyl compound (hereinafter referred to as compound A) disclosed in the Chinese invention patent CN 105541682 A has a relatively excellent effect of killing and controlling acarids, and has broad market application prospects. Compound A has the following structure: [0003] [0004] As mentioned in the aforementioned invention patent CN 105541682 A, the use form of the compound can be dry powder, wettable powder, emulsifiable concentrate, microemulsion, paste, granule, solution, suspension, etc., but the use form of the compound described in the patent is Prepared in known manner, for example by diluting or dissolving the active substance with solvent media and / or solid diluents, optionally in the presence of surfactants, but the choice of the type of use of the compound ...

AI Technical Summary

Problems solved by technology

[0005] Compound A, as a low melting point active substance, has a melting point of 50-60°C. After being prepared as a solid preparation, due to its own low melting point characteristics, especially in the storage accelerated test, the solid particles will soften and the shape will change. Some The role of auxiliary agents, especially dispersants, is weakened, and the suspension rate of the preparation will be greatly reduced, resulting in unqualified suspension rate, which will eventually affect the use of the preparation

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