Biphenyl compound-containing solid preparation and applications thereof

A solid preparation and compound technology, which is applied in the field of solid preparations containing biphenyl compounds, can solve problems such as the weakening of the auxiliary agent and dispersant, the decrease of the suspension rate of the preparation, and the unqualified suspension rate, so as to achieve product performance guarantee and qualified suspension rate , Inhibit the effect of softening and dissolving

Active Publication Date: 2020-03-10
SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Compound A, as a low melting point active substance, has a melting point of 50-60°C. After being prepared as a solid preparation, due to its own low melting point characteristics, especially in the storage accelerated test, the solid particles will soften a

Method used

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  • Biphenyl compound-containing solid preparation and applications thereof
  • Biphenyl compound-containing solid preparation and applications thereof
  • Biphenyl compound-containing solid preparation and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 120

[0043] The preparation of embodiment 1.20% compound A-1 wettable powder

[0044] 20% of compound A-1, 5% of calcium lignosulfonate, 3% of D-425, 5% of white carbon black, and the balance of light calcium carbonate to 100%, then 20% of compound A-1 with good physical properties can be obtained wettable powder.

Embodiment 220

[0045] The preparation of embodiment 2.20% compound A-1 wettable powder

[0046] 20% of compound A-1, 5% of calcium lignosulfonate, 3% of D-425, 5% of white carbon black, 0.1% of liquiritin, and the balance of light calcium carbonate to 100%, can obtain 20 % Compound A-1 wettable powder.

Embodiment 330

[0047] The preparation of embodiment 3.30% compound A-2 granules

[0048] Mix 30% of compound A-2 and 8% of diatomaceous earth to obtain mother powder, then add 5% PVA and mix with quartz sand to obtain 30% compound A-2 granules with good physical properties.

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Abstract

The invention belongs to the field of acaricides, and relates to a biphenyl compound-containing solid preparation and applications thereof, wherein a compound A is used as an active component and is matched with at least a carrier and at least an auxiliary agent, the weight percentage content of the active component compound A of the solid preparation is 0.5-90%, the auxiliary agent contains a suspending aid, and the weight percentage content of the suspending aid is 0.01-5%. According to the invention, a proper auxiliary agent system condition is selected and matched, a suspending aid substance liquiritin is added into the solid preparation according to a specific ratio to effectively improve the suspension rate of the solid preparation, and the liquiritin and the structure of the compound A interact, so that the defects of softening and dissolving of solid particles are inhibited, the problems that low-melting-point raw medicine solid preparation particles are prone to melting and softening and low in suspension rate in the prior art are solved, the suspension rate of the solid preparation is qualified, the product performance is guaranteed, and the unexpected effect is achieved.

Description

technical field [0001] The invention belongs to the field of acaricides, and relates to a solid preparation containing biphenyl compounds and an application thereof. Background technique [0002] The biphenyl compound (hereinafter referred to as compound A) disclosed in the Chinese invention patent CN 105541682 A has a relatively excellent effect of killing and controlling acarids, and has broad market application prospects. Compound A has the following structure: [0003] [0004] As mentioned in the aforementioned invention patent CN 105541682 A, the use form of the compound can be dry powder, wettable powder, emulsifiable concentrate, microemulsion, paste, granule, solution, suspension, etc., but the use form of the compound described in the patent is Prepared in known manner, for example by diluting or dissolving the active substance with solvent media and / or solid diluents, optionally in the presence of surfactants, but the choice of the type of use of the compound ...

Claims

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Application Information

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IPC IPC(8): A01N41/10A01N25/22A01P7/02
CPCA01N25/22A01N41/10
Inventor 丑靖宇遇璐李洋吴鸿飞于海波
Owner SHENYANG SINOCHEM AGROCHEMICALS R&D CO LTD
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