The invention discloses a method for preparing a high-strength and high-toughness aluminum alloy die forging for an aircraft wing, and relates to the field of preparation of an aluminum alloy die forging. The method solves the technical problems that macrostructures of an existing die forging have serious eddy and through-flow defects, the probability of breakage of the die forging in the high-speed operation process is greatly increased, and the aircraft safety is seriously affected. The method has the following steps that 1. an aluminum alloy ingot is prepared; 2, heating and extruding are carried out on the ingot; 3, heating and bending are carried out; 4, flattening is carried out; 5, pre-press forming is carried out; 6, acid-base washing treatment is carried out; 7, die forging forming is carried out; 8, erosive washing repairing is carried out; 9, die forging heat treatment and performance testing are carried out; and 10, ultrasonic testing is carried out, and the die forging isobtained. The macrostructures of the die forging obtained through the method do not have no through-flow and coarse-grain defects, the probability of breakage of the die forging in the high air is greatly reduced, and the die forging has the comprehensive properties of high strength, heat resistance, good toughness and the like. The method is used for preparing the high-strength and high-toughnessaluminum alloy die forging for the aircraft wing.