A kind of rosemary essential oil nano liposome and its preparation method and application
A technology of rosemary essential oil and nano-liposomes, which is applied in liposome delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of liposomes lack of viscosity and thixotropy, and achieve increased retention Quantity and retention time, good sustained-release effect, and the effect of using less reagents
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Embodiment 1
[0032] A preparation method of rosemary essential oil nano liposome, the method comprises the following steps:
[0033] (1) Take the fresh leaves of rosemary and dry them in the shade, then place them in water for steam distillation to extract the essential oil, the mass ratio of dry rosemary leaves to water is 1:10 during extraction, and distill and extract for 3 hours;
[0034] (2) dissolving rosemary essential oil in caprylic triglyceride and mixing uniformly to obtain the first mixture; wherein the mass ratio of rosemary essential oil to capric triglyceride is 1:35;
[0035] (3) Dissolve the poloxamer melted at 70°C in deionized water and mix evenly, then let it stand for 24 hours, and stir it fully after standing to obtain the second mixture; the amount of melted poloxamer and deionized water The ratio is 3g: 16ml;
[0036] (4) The second mixture is continuously and slowly added to the first mixture (mixing with the mass ratio of rosemary essential oil and molten poloxam...
Embodiment 2
[0039] A preparation method of rosemary essential oil nano liposome, the method comprises the following steps:
[0040] (1) Take the fresh leaves of rosemary and dry them in the shade, then place them in water for steam distillation to extract the essential oil, the mass ratio of the shade-dried rosemary leaves to water is 1:14, and distill and extract for 3.5 hours;
[0041] (2) dissolving rosemary essential oil in caprylic triglyceride and mixing uniformly to obtain the first mixture; wherein the mass ratio of rosemary essential oil to capric triglyceride is 1:50;
[0042] (3) Dissolve the poloxamer melted at 70°C in deionized water and mix evenly, then let it stand for 24 hours, and stir it fully after standing to obtain the second mixture; the amount of melted poloxamer and deionized water The ratio is 3g: 40ml;
[0043](4) The second mixture is continuously and slowly added to the first mixture (mixed with a mass ratio of rosemary essential oil and molten poloxamer of 1:...
Embodiment 3
[0046] A preparation method of rosemary essential oil nano liposome, the method comprises the following steps:
[0047] (1) Take the fresh leaves of rosemary and dry them in the shade, then place them in water for steam distillation to extract the essential oil, the mass ratio of the shade-dried rosemary leaves to water is 1:12, and distill and extract for 3 hours;
[0048] (2) dissolving rosemary essential oil in caprylic triglyceride and mixing uniformly to obtain the first mixture; wherein the mass ratio of rosemary essential oil to capric triglyceride is 1:42;
[0049] (3) Dissolve the poloxamer melted at 70°C in deionized water and mix evenly, then let it stand for 24 hours, and stir it fully after standing to obtain the second mixture; the amount of melted poloxamer and deionized water The ratio is 3g: 28ml;
[0050] (4) The second mixture is continuously and slowly added to the first mixture (mixed with the mass ratio of rosemary essential oil and molten poloxamer as 1...
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